Patents by Inventor Catherine E. Thomasson

Catherine E. Thomasson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
    Patent number: 8524904
    Abstract: The present invention is directed to the preparation of 6-hydroxy morphinans having formula (II) or N-alkylated 6-hydroxy morphinans having formula (III).
    Type: Grant
    Filed: December 3, 2009
    Date of Patent: September 3, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Peter X. Wang, Tao Jiang, Gary L. Cantrell, Frank W. Moser, Catherine E. Thomasson
  • Preparation of 6-alpha-amino N-substituted morphinans by catalytic hydrogen transfer
    Patent number: 8519133
    Abstract: The present invention provides processes for the stereoselective synthesis of 6-alpha-amino N-substituted morphinans. In particular, the invention provides processes for the reductive amination of 6-keto N-substituted morphinans by catalytic hydrogen transfer.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: August 27, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Gary L. Cantrell, Joseph P. McClurg, Catherine E. Thomasson, Frank W. Moser
  • Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
    Patent number: 8471023
    Abstract: The present invention provides processes for the stereoselective synthesis of 6-alpha-amino morphinans. In particular, the invention provides processes for the reductive amination of 6-keto normorphinans by catalytic transfer hydrogenation.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: June 25, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Gary L. Cantrell, Joseph P. McClurg, Catherine E. Thomasson, Frank W. Moser
  • Process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
    Patent number: 8273888
    Abstract: The present invention is directed to the preparation of 6-keto morphinans.
    Type: Grant
    Filed: December 3, 2009
    Date of Patent: September 25, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Peter X. Wang, Tao Jiang, Gary L. Cantrell, Frank W. Moser, Catherine E. Thomasson
  • Processes for the selective amination of ketomorphinans
    Patent number: 8269006
    Abstract: The present invention is generally directed to a process for the preparation of a ketomorphinan comprising maintaining a ketone group as unprotected and performing reductive amination using a hydrogen source and a catalyst.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: September 18, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Edmund C. Hudson, Douglas Teramura, Christopher W. Grote, Catherine E. Thomasson, Gary L. Cantrell
  • N-Alkylation of Opiates
    Publication number: 20110269964
    Abstract: The present invention provides an efficient process for preparing N-alkylated opiates. In particular, processes are provided for using a chloride-containing alkylating agent and a bromide or iodide salt to alkylate the corresponding nor-opiate.
    Type: Application
    Filed: April 28, 2011
    Publication date: November 3, 2011
    Applicant: Mallinckrodt Inc.
    Inventors: Jian Bao, Catherine E. Thomasson, Esa T. Jarvi
  • Process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
    Patent number: 7985858
    Abstract: The present invention is directed to the conversion of a 6-keto morphinan to a 6-alpha-hydroxy morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.
    Type: Grant
    Filed: May 2, 2008
    Date of Patent: July 26, 2011
    Assignee: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Peter X. Wang, Tao Jiang, Gary L. Cantrell, Frank W. Moser, Catherine E. Thomasson
  • Remove Amination of 6-Keto Normorphinans by Catalytic Hydrogen Transfer
    Publication number: 20100317861
    Abstract: The present invention provides processes for the stereoselective synthesis of 6-alpha-amino morphinans. In particular, the invention provides processes for the reductive amination of 6-keto normorphinans by catalytic transfer hydrogenation.
    Type: Application
    Filed: June 10, 2010
    Publication date: December 16, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Gary L. Cantrell, Joseph P. McClurg, Catherine E. Thomasson, Frank W. Moser
  • Preparation of 6-Alpha-Amino N-Substituted Morphinans by Catalytic Hydrogen Transfer
    Publication number: 20100317683
    Abstract: The present invention provides processes for the stereoselective synthesis of 6-alpha-amino N-substituted morphinans. In particular, the invention provides processes for the reductive amination of 6-keto N-substituted morphinans by catalytic hydrogen transfer.
    Type: Application
    Filed: June 10, 2010
    Publication date: December 16, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Gary L. Cantrell, Joseph P. McClurg, Catherine E. Thomasson, Frank W. Moser
  • Process for the Preparation of 6-Alpha-Hydroxy-N-Alkylated Opiates
    Publication number: 20100113788
    Abstract: The present invention is directed to the preparation of 6-keto morphinans.
    Type: Application
    Filed: December 3, 2009
    Publication date: May 6, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Peter X. Wang, Tao Jiang, Gary L. Cantrell, Frank W. Moser, Catherine E. Thomasson
  • Processes for the selective amination of ketomorphinans
    Publication number: 20100081817
    Abstract: The present invention is generally directed to a process for the preparation of a ketomorphinan comprising maintaining a ketone group as unprotected and performing reductive amination using a hydrogen source and a catalyst.
    Type: Application
    Filed: September 29, 2009
    Publication date: April 1, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Edumnd C. Hudson, Douglas Teramura, Christopher W. Grote, Catherine E. Thomasson, Gary L. Cantrell
  • Process for the Preparation of 6-Alpha-Hydroxy-N-Alkylated Opiates
    Publication number: 20100081818
    Abstract: The present invention is directed to the preparation of 6-hydroxy morphinans having formula (II) or N-alkylated 6-hydroxy morphinans having formula (III).
    Type: Application
    Filed: December 3, 2009
    Publication date: April 1, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Peter X. Wang, Tao Jiang, Gary L. Cantrell, Frank W. Moser, Catherine E. Thomasson
  • Process for the Preparation of 6-Alpha-Hydroxy-N-Alkylated Opiates
    Publication number: 20100041888
    Abstract: The present invention is directed to the conversion of a 6-keto morphinan to a 6-alpha-hydroxy morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.
    Type: Application
    Filed: May 2, 2008
    Publication date: February 18, 2010
    Inventors: Christopher W. Grote, Peter X. Wang, Tao Jiang, Gary L. Cantrell, Frank W. Moser, Catherine E. Thomasson
  • Crystalline Form of Remifentanil Hydrochloride
    Publication number: 20080319197
    Abstract: The present invention relates to a crystalline polymorphic form of remifentanil hydrochloride. The invention also describes methods of preparing a polymorphic form of remifentanil hydrochloride.
    Type: Application
    Filed: January 19, 2007
    Publication date: December 25, 2008
    Inventors: Brian K. Cheng, Gary A. Nichols, Catherine E. Thomasson
  • Method of suppression of hydrogen sulfide with heterocyclic-amine aldehyde reaction products
    Patent number: 5266185
    Abstract: Hydrogen sulfide evolution in a heavy hydrocarbon (such as a residual fuel oil) derived from a heavy crude oil (such as a API 8 gravity crude) is suppressed by contacting the hydrocarbon with a compound corresponding to the reaction product of a heterocyclic aldehyde (such as furfural) and an organic primary amine.
    Type: Grant
    Filed: September 10, 1990
    Date of Patent: November 30, 1993
    Assignee: Petrolite Corporation
    Inventors: Jerry J. Weers, Timothy J. O'Brien, Catherine E. Thomasson
  • Hydrogen sulfide scavengers in fuels, hydrocarbons and water using amidines and polyamidines
    Patent number: 5223127
    Abstract: A method for scavenging hydrogen sulfide in an aqueous and/or hydrocarbon medium is disclosed. According to the method, the medium is contacted with an effective amount of an amidine selected from the group consisting of monoamidines of from 1 to about 18 carbon atoms and polyamidines comprising from 2 to 3 amidine groups of from 1 to about 18 carbon atoms per amidine group.
    Type: Grant
    Filed: July 18, 1991
    Date of Patent: June 29, 1993
    Assignee: Petrolite Corporation
    Inventors: Jerry J. Weers, Catherine E. Thomasson