Abstract: A solid matrix sustained release ophthalmic formulation for topical delivery of a solid ophthalmic drug to the eye, medical devices, drug cores, drug inserts and drug delivery systems comprising the formulation, methods of manufacturing the formulation, medical devices and their methods thereof for delivering the ophthalmic drug for a treatment period provided herein. The formulation disclosed herein is an admixture of an ophthalmic drug, and a combination of a hydrophobic polymer, a hydrophilic polymer and a surfactant, wherein the drug is eluted daily over an extended period of time at therapeutic dose of drug.

Abstract: Disclosed are systems and methods for identifying an available product for an unavailable product to minimize a deviation or distance from an original planned pick path. A computer can transmit instructions corresponding to a path through a location where products are stored to collect a plurality of products stored at locations along the path. In response to receiving a notification for a particular product that the particular product is not at the location where it is stored, the computer can modify the path to include a location of a substitute product for the particular product. The computer can identify a substitute product for the particular product based on a distance from a location of the one more available products to a location along the path and determine a revised path with the substitute product. The path can be revised to include the location for the available product.

Abstract: Laundry detergent compositions including alginate lyase enzyme, hexosaminidase enzyme and anionic surfactant. Methods of treating fabrics by contacting the fabric with an aqueous wash liquor having the detergent composition therein. The compositions and methods are particularly for improving whiteness of a fabric, improved soil removal from a fabric, for malodour removal from a fabric, for anti-wrinkle benefits, collar and/or cuff cleaning, anti-redeposition benefits and/or for improved drying of a fabric.

Abstract: A composition including an alginate lyase enzyme and cleaning adjunct. Methods of treating surfaces by contacting the surface with an aqueous wash liquor having the detergent composition therein.

Abstract: Example systems, methods, and apparatus to optimize autonomous vehicle workflows are disclosed. An example apparatus includes at least one memory; instructions; and a processor to execute the instructions to determine an expected arrival time for an autonomous vehicle at a first location, the autonomous vehicle to deliver a first product to the first location in response to a first task assigned to the autonomous vehicle, the first product associated with a first order; perform a comparison between the expected arrival time for the autonomous vehicle and an expected arrival time associated with a second task; select a third task to be performed by the autonomous vehicle based on the comparison, the third task selected for having the autonomous vehicle arrive at the first location after performance of the third task within a threshold time of the expected arrival time; and instruct the autonomous vehicle to perform the third task.

Abstract: Example systems, methods, and apparatus to optimize autonomous vehicle workflows are disclosed. An example apparatus includes at least one memory; instructions; and a processor to execute the instructions to determine an expected arrival time for an autonomous vehicle at a first location, the autonomous vehicle to deliver a first product to the first location in response to a first task assigned to the autonomous vehicle, the first product associated with a first order; perform a comparison between the expected arrival time for the autonomous vehicle and an expected arrival time associated with a second task; select a third task to be performed by the autonomous vehicle based on the comparison, the third task selected for having the autonomous vehicle arrive at the first location after performance of the third task within a threshold time of the expected arrival time; and instruct the autonomous vehicle to perform the third task.

Abstract: Disclosed are systems and methods for identifying an available product for an unavailable product to minimize a deviation or distance from an original planned pick path. A computer can transmit instructions corresponding to a path through a location where products are stored to collect a plurality of products stored at locations along the path. In response to receiving a notification for a particular product that the particular product is not at the location where it is stored, the computer can modify the path to include a location of a substitute product for the particular product. The computer can identify a substitute product for the particular product based on a distance from a location of the one more available products to a location along the path and determine a revised path with the substitute product. The path can be revised to include the location for the available product.

Abstract: Compositions including an alginate lyase enzyme and anionic surfactant. Methods of treating fabrics by contacting the fabric with an aqueous wash liquor having a detergent composition with an alginate lyase enzyme.

Abstract: Laundry detergent compositions can include an alginate lyase enzyme, nuclease enzyme, and anionic surfactant. Also included are methods of treating fabrics by contacting the fabric with an aqueous wash liquor having the laundry detergent composition which includes an alginate lyase enzyme, nuclease enzyme, and anionic surfactant.

Abstract: Compositions including an alginate lyase enzyme and anionic surfactant. Methods of treating fabrics by contacting the fabric with an aqueous wash liquor having the detergent composition therein. The compositions and methods are particularly for improving whiteness of a fabric, improved soil removal from a fabric, for malodour removal from a fabric, for anti-wrinkle benefits, anti-redeposition benefits and/or for improved drying of a fabric.

Abstract: Disclosed are systems and methods for dynamically re-routing a pick path to an alternate pick location in response to identifying a shorted product at a pick location. The dynamic decision to re-route an autonomous vehicle is based on completion scores representing a likelihood of completing order in an autonomous vehicle, a maximum remaining time, an additional pick time, and order priorities. Based on various weights for factors of the orders, a system may re-route the autonomous vehicle to fulfill a shorted order at an alternate location when no orders have a high likelihood of completion, the additional pick time associated with re-routing the autonomous vehicle to the alternate pick location is less than the maximum remaining time for each order on the autonomous vehicle, and/or none of the orders on the autonomous vehicle have a higher priority than the shorted order.

Abstract: A solid matrix sustained release ophthalmic formulation for topical delivery of a solid ophthalmic drug to the eye, medical devices, drug cores, drug inserts and drug delivery systems comprising the formulation, methods of manufacturing the formulation, medical devices and their methods thereof for delivering the ophthalmic drug for a treatment period provided herein. The formulation disclosed herein is an admixture of an ophthalmic drug, and a combination of a hydrophobic polymer, a hydrophilic polymer and a surfactant, wherein the drug is eluted daily over an extended period of time at therapeutic dose of drug.

Abstract: Disclosed are systems and methods for dynamically routing autonomous vehicles to minimize the time spent navigating a warehouse. A system may dynamically route autonomous vehicles based on a weighted arrangement (or combination) of factors including: the route determined for other autonomous vehicles, the pick lists associated with the autonomous vehicles, the pick list priority, the picker's current location, the autonomous vehicles' current location, the picker's assignment to an autonomous vehicle, the picker's progress in completing his/her tasks, the picker's projected location, the autonomous vehicles' projected location, the nearest autonomous vehicle to a picker in time based on the picker's walking speed, the nearest autonomous vehicle in urgency, the nearest autonomous vehicle in distance, autonomous vehicle battery level, orders already placed on an autonomous vehicle, priority pickers, products to be picked that can be prioritized over other pickers and/or picking routes.

Abstract: Disclosed are systems and methods for dynamically routing pickers and autonomous vehicles to avoid areas closed to travel by the autonomous vehicles within a warehouse. A processor in communication with an autonomous vehicle and an electronic device operated by a user (e.g., handheld device) may, in response to detecting that the electronic device diverges from a path of the autonomous vehicle, provide, for display on the electronic device, information about the product. The processor may then determine a rendezvous location for the autonomous vehicle based on a location of the product. The processor may then instruct the autonomous vehicle to navigate to the rendezvous location and transmit the rendezvous location to the electronic device.

Abstract: Disclosed are systems and methods for dynamically re-routing a pick path to an alternate pick location in response to identifying a shorted product at a pick location. The dynamic decision to re-route an autonomous vehicle is based on completion scores representing a likelihood of completing order in an autonomous vehicle, a maximum remaining time, an additional pick time, and order priorities. Based on various weights for factors of the orders, a system may re-route the autonomous vehicle to fulfill a shorted order at an alternate location when no orders have a high likelihood of completion, the additional pick time associated with re-routing the autonomous vehicle to the alternate pick location is less than the maximum remaining time for each order on the autonomous vehicle, and/or none of the orders on the autonomous vehicle have a higher priority than the shorted order.

Abstract: Identifying a residue-component in a residue on a surface, comprising using molecular probes selected from the group comprising antibodies, affimers, aptamers, lectins, carbohydrate binding modules and mixtures thereof. The residue-component may be a soil or surface treatment component. The method can be used to make or improve cleaning or treatment compositions or processes.

Abstract: Disclosed are systems and methods for identifying an available product for an unavailable product to minimize a deviation or distance from an original planned pick path. A computer can transmit instructions corresponding to a path through a location where products are stored to collect a plurality of products stored at locations along the path. In response to receiving a notification for a particular product that the particular product is not at the location where it is stored, the computer can modify the path to include a location of a substitute product for the particular product. The computer can identify a substitute product for the particular product based on a distance from a location of the one more available products to a location along the path and determine a revised path with the substitute product. The path can be revised to include the location for the available product.

Abstract: A solid matrix sustained release ophthalmic formulation for topical delivery of a solid ophthalmic drug to the eye, medical devices, drug cores, drug inserts and drug delivery systems comprising the formulation, methods of manufacturing the formulation, medical devices and their methods thereof for delivering the ophthalmic drug for a treatment period provided herein. The formulation disclosed herein is an admixture of an ophthalmic drug, and a combination of a hydrophobic polymer, a hydrophilic polymer and a surfactant, wherein the drug is eluted daily over an extended period of time at therapeutic dose of drug.

Abstract: A poppet valve assembly for a high-speed compressor, the poppet valve assembly including a cage that includes a plurality of counter bores disposed therein. The poppet valve assembly further includes a plurality of poppets, each poppet having a stem and a head. The head of each poppet has a maximum diameter that is less than approximately 0.75 inches. The stem of the poppet is disposed in each of said counter bores. The poppet valve assembly also includes a seat plate overlying said cage, said seat plate including a plurality of through bores axially aligned with the counter bores of the cage. Each through bore is sized to have a smaller diameter than the maximum diameter of the head. A lift spacer is disposed in each of the counter bores.

Abstract: A solid matrix sustained release ophthalmic formulation for topical delivery of a solid ophthalmic drug to the eye, medical devices, drug cores, drug inserts and drug delivery systems comprising the formulation, methods of manufacturing the formulation, medical devices and their methods thereof for delivering the ophthalmic drug for a treatment period provided herein. The formulation disclosed herein is an admixture of an ophthalmic drug, and a combination of a hydrophobic polymer, a hydrophilic polymer and a surfactant, wherein the drug is eluted daily over an extended period of time at therapeutic dose of drug.