Abstract: A method of separating a solute from a supercritical fluid which includes reducing the pressure of the supercritical fluid and is characterized in that the supercritical fluid and solute are mixed with another fluid, eg an inorganic or organic solvent under pressure, to cause a partial reduction in the pressure of the supercritical fluid followed by reduction of the pressure of the fluid mixture comprising the supercritical fluid and said other fluid. The fluid mixture pressure reduction may occur in a collection device. Such a device may have a collection solvent already present therein. The said other fluid used partially to depressurise the supercritical fluid may act as a collection solvent in a collection device. The collection device may include one or more collection vessels or alternatively a solid phase trap or a packed column for the purpose of trapping and collecting the solute.