Abstract: The disclosed apparatus, systems and methods relate to the use of optical nanoparticles in the illumination and imaging of tissues such as cancer tissues. Optical nanoparticles such as upconverting nanoparticles can be introduced into a patient and illuminated at a first time and wavelength and then imaged at a second time and wavelength to improve resolution and reduce imager size.

Abstract: The disclosed apparatus, systems and methods relate to devices, systems and methods for intra-operative imaging.

Abstract: The disclosed apparatus, systems and methods relate to devices, systems and methods for intra-operative imaging.

Abstract: The disclosed apparatus, systems and methods relate to devices, systems and methods for intra-operative imaging.

Abstract: The disclosed apparatus, systems and methods relate to devices, systems and methods for intraoperative imaging.

Abstract: The disclosed apparatus, systems and methods relate to interventional magnetic resonance imaging (iMRI).

Abstract: An imager for in vivo viewing of diseased tissue by way of fluorescently conjugated molecules. A generally planar imaging surface with a microlens array. The imager may be modular, such that a plurality of generally planar imaging surfaces can be used to image various aspects of disease tissue simultaneously. Certain implementations include an angle-selective imager, wherein light from substantially perpendicular to the plane of the imager is received, while incident light is selectively eliminated.

Abstract: An imager for in vivo viewing of diseased tissue by way of fluorescently conjugated molecules. A generally planar imaging surface with a microlens array. The imager may be modular, such that a plurality of generally planar imaging surfaces can be used to image various aspects of disease tissue simultaneously. Certain implementations include an angle-selective imager, wherein light from substantially perpendicular to the plane of the imager is received, while incident light is selectively eliminated.

Abstract: A method for increasing or monitoring apoptosis in tumor cells by the co-administration of ionizing radiation and an anti-integrin antibody. Increasing apoptosis reduces tumor growth in vivo and in a cell culture model. The antibody is directed against the beta-1 integrin subunit and is inhibitory of beta-1 integrin signaling. Other molecules having an inhibitory effect on beta-1 integrin, either in signaling or in binding to its cognate extracellular receptors may also be used. The present method is particularly of interest in treatment of tumor cells associated with breast cancer, wherein radiation is currently used alone. The present method further contemplates a monoclonal antibody suitable for human administration that may further comprise a radioisotope attached thereto.

Abstract: A method for increasing or monitoring apoptosis in tumor cells by the co-administration of ionizing radiation and an anti-integrin antibody. Increasing apoptosis reduces tumor growth in vivo and in a cell culture model. The antibody is directed against the beta-1 integrin subunit and is inhibitory of beta-1 integrin signaling. Other molecules having an inhibitory effect on beta-1 integrin, either in signaling or in binding to its cognate extracellular receptors may also be used. The present method is particularly of interest in treatment of tumor cells associated with breast cancer, wherein radiation is currently used alone. The present method further contemplates a monoclonal antibody suitable for human administration that may further comprise a radioisotope attached thereto.

Abstract: A method for increasing or monitoring apoptosis in tumor cells by the co-administration of ionizing radiation and an anti-integrin antibody. Increasing apoptosis reduces tumor growth in vivo and in a cell culture model. The antibody is directed against the beta-1 integrin subunit and is inhibitory of beta-1 integrin signaling. Other molecules having an inhibitory effect on beta-1 integrin, either in signaling or in binding to its cognate extracellular receptors may also be used. The present method is particularly of interest in treatment of tumor cells associated with breast cancer, wherein radiation is currently used alone. The present method further contemplates a monoclonal antibody suitable for human administration that may further comprise a radioisotope attached thereto.

Abstract: A method for increasing or monitoring apoptosis in tumor cells by the co-administration of ionizing radiation and an anti-integrin antibody. Increasing apoptosis reduces tumor growth in vivo and in a cell culture model. The antibody is directed against the beta-1 integrin subunit and is inhibitory of beta-1 integrin signaling. Other molecules having an inhibitory effect on beta-1 integrin, either in signaling or in binding to its cognate extracellular receptors may also be used. The present method is particularly of interest in treatment of tumor cells associated with breast cancer, wherein radiation is currently used alone. The present method further contemplates a monoclonal antibody suitable for human administration that may further comprise a radioisotope attached thereto.

Abstract: Disclosed is a picture postcard mailer for mailing and framing photographs and the like. The mailer includes a frame portion defining an aperture therethrough and further defining a cross-sectional pocket therein. The cross-sectional pocket is dimensioned and configured to retain an image within it such that the image is visible through the aperture. A stand portion is connected to the frame portion and is movable between a retracted position and an extended position. A detachable writing surface is attached to a peripheral edge of the frame portion. Means for maintaining the stand portion in the extended position are provided so that the postcard mailer can be displayed when received.