Patents by Inventor Catherine PILSMAKER
Catherine PILSMAKER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11931737Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: GrantFiled: September 7, 2022Date of Patent: March 19, 2024Assignee: CELLINO BIOTECH, INC.Inventors: Matthias Wagner, Suvi Aivio, Mariangela Amenduni, Catherine Pilsmaker, Arnaldo Pereira, Ananya Zutshi, Ozge Whiting, George Harb, Steven Nagle, Anthia Toure, Matthew Sullivan, Maya Berlin-Udi, Lukas Vasadi, Alexander Stange, Sangkyun Lee, Stefanie Morgan, Nick Seay, Scott Luro
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Publication number: 20240067914Abstract: Systems and methods are disclosed for processes related to cell culture and generation.Type: ApplicationFiled: August 15, 2023Publication date: February 29, 2024Inventors: Matthias Wagner, Suvi Aivio, Catherine Pilsmaker, Mariangela Amenduni, Amaldo Pereira, Sangkyun Lee, Scott Luro, Stefanie Morgan, Matthew Sullivan, Maya Berlin-Udi, Deniz Aksel, Jason Natale
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Publication number: 20240067917Abstract: Systems and methods are disclosed for processes related to cell culture and generation. A system for culturing cells comprises a cell culture container comprising a first surface, the first surface being configured for one or more cell colonies to adhere thereto; an image sensor configured to capture one or more time-series images of a first cell colony in the one or more cell colonies; a computing subsystem configured to iteratively manage a surface area of the first cell colony according to a method comprising: calculating the surface area of the first cell colony as the first cell colony proliferates, selecting a portion of the first cell colony to remove to reduce the surface area of the first cell colony when its surface area is above a predetermined threshold, and removing, using a cell removal tool, the selected portion of the first cell colony from the first surface.Type: ApplicationFiled: August 15, 2023Publication date: February 29, 2024Inventors: Matthias Wagner, Suvi Aivio, Catherine Pilsmaker, Mariangela Amenduni, Arnaldo Pereira, Sangkyun Lee, Scott Luro, Stefanie Morgan, Matthew Sullivan, Maya Berlin-Udi, Deniz Aksel, Jason Natale
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Publication number: 20240067916Abstract: Systems and methods are disclosed for processes related to cell culture and generation. A system for culturing cells a cell culture container comprises a first surface, the first surface being configured for a plurality of cell colonies to continuously adhere thereto throughout a cell culture process; an image sensor configured to capture one or more time-series images of the plurality of cell colonies during the cell culture process; a cell removal tool configured to remove one or more cells from the first surface of the cell culture container during the cell culture process; and a computing subsystem configured to: track one or more characteristics of the plurality of cell colonies based on the one or more time-series images, and control the cell removal tool to remove cells based on the one or more characteristics.Type: ApplicationFiled: August 15, 2023Publication date: February 29, 2024Inventors: Matthias Wagner, Suvi Aivio, Catherine Pilsmaker, Mariangela Amenduni, Amaldo Pereira, Sangkyun Lee, Scott Luro, Stefanie Morgan, Matthew Sullivan, Maya Berlin-Udi, Deniz Aksel, Jason Natale
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Patent number: 11913029Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: GrantFiled: December 5, 2022Date of Patent: February 27, 2024Assignee: CELLINO BIOTECH, INC.Inventors: Matthias Wagner, Suvi Aivio, Mariangela Amenduni, Catherine Pilsmaker, Arnaldo Pereira, Ananya Zutshi, Anthia Toure, Steven Nagle, Ozge Whiting, George Harb, Matthew Sullivan, Maya Berlin-Udi, Stefanie Morgan, Nick Seay, Sang Lee, Scott Luro
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Publication number: 20240052321Abstract: Systems and methods are disclosed for processes related to cell culture and generation. A system for culturing cells comprises a cell culture container comprises a closed cell culture chamber enclosing a fluid media and a first surface configured for a cell culture to adhere thereto; a cell removal tool configured to selectively remove one or more cells from the first surface of the cell culture container; and a controller configured to iteratively remove one or more cells using the cell removal tool and thereby maintain the cell culture below a threshold density throughout a cell culture process, wherein the cell culture chamber is configured to seal during the cell culture process.Type: ApplicationFiled: August 15, 2023Publication date: February 15, 2024Inventors: Matthias Wagner, Suvi Aivio, Catherine Pilsmaker, Mariangela Amenduni, Arnaldo Pereira, Sangkyun Lee, Scott Luro, Stefanie Morgan, Matthew Sullivan, Maya Berlin-Udi, Deniz Aksel, Jason Natale
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Patent number: 11866735Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: GrantFiled: March 7, 2022Date of Patent: January 9, 2024Assignee: CELLINO BIOTECH, INC.Inventors: Matthias Wagner, Suvi Aivio, Mariangela Amenduni, Catherine Pilsmaker, Arnaldo Pereira, Ananya Zutshi, Anthia Toure, Steven Nagle, Ozge Whiting, George Harb, Matthew Sullivan, Maya Berlin-Udi, Stefanie Morgan, Nick Seay, Sang Lee, Scott Luro
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Publication number: 20230332111Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: ApplicationFiled: June 22, 2023Publication date: October 19, 2023Inventors: Matthias WAGNER, Suvi AIVIO, Mariangela AMENDUNI, Catherine PILSMAKER, Arnaldo PEREIRA, Ananya ZUTSHI, Anthia TOURE, Steven NAGLE, Ozge WHITING, George HARB, Matthew SULLIVAN, Maya BERLIN-UDI, Stefanie MORGAN, Nick SEAY, Sang LEE, Scott LURO
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Publication number: 20230265394Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: ApplicationFiled: April 27, 2023Publication date: August 24, 2023Inventors: Matthias WAGNER, Suvi AIVIO, Mariangela AMENDUNI, Catherine PILSMAKER, Arnaldo PEREIRA, Ananya ZUTSHI, Anthia TOURE, Steven NAGLE, Ozge WHITING, George HARB, Matthew SULLIVAN, Maya BERLIN-UDI, Stefanie MORGAN, Nick SEAY, Sang LEE, Scott LURO
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Publication number: 20230235295Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: ApplicationFiled: March 27, 2023Publication date: July 27, 2023Inventors: Matthias WAGNER, Suvi AIVIO, Mariangela AMENDUNI, Catherine PILSMAKER, Arnaldo PEREIRA, Ananya ZUTSHI, Anthia TOURE, Steven NAGLE, Ozge WHITING, George HARB, Matthew SULLIVAN, Maya BERLIN-UDI, Stefanie MORGAN, Nick SEAY, Sang LEE, Scott LURO
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Patent number: 11708563Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: GrantFiled: March 7, 2022Date of Patent: July 25, 2023Assignee: CELLINO BIOTECH, INC.Inventors: Matthias Wagner, Suvi Aivio, Mariangela Amenduni, Catherine Pilsmaker, Arnaldo Pereira, Ananya Zutshi, Anthia Toure, Steven Nagle, Ozge Whiting, George Harb, Matthew Sullivan, Maya Berlin-Udi, Stefanie Morgan, Nick Seay, Sang Lee, Scott Luro
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Patent number: 11680247Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: GrantFiled: March 7, 2022Date of Patent: June 20, 2023Assignee: CELLINO BIOTECH, INC.Inventors: Matthias Wagner, Suvi Aivio, Mariangela Amenduni, Catherine Pilsmaker, Arnaldo Pereira, Ananya Zutshi, Anthia Toure, Steven Nagle, Ozge Whiting, George Harb, Matthew Sullivan, Maya Berlin-Udi, Stefanie Morgan, Nick Seay, Sang Lee, Scott Luro
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Publication number: 20230095664Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: ApplicationFiled: December 5, 2022Publication date: March 30, 2023Inventors: Matthias WAGNER, Suvi AIVIO, Mariangela AMENDUNI, Catherine PILSMAKER, Arnaldo PEREIRA, Ananya ZUTSHI, Anthia TOURE, Steven NAGLE, Ozge WHITING, George HARB, Matthew SULLIVAN, Maya BERLIN-UDI, Stefanie MORGAN, Nick SEAY, Sang LEE, Scott LURO
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Publication number: 20230065504Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: ApplicationFiled: September 7, 2022Publication date: March 2, 2023Inventors: Matthias WAGNER, Suvi AIVIO, Mariangela AMENDUNI, Catherine PILSMAKER, Arnaldo PEREIRA, Ananya ZUTSHI, Ozge WHITING, George HARB, Steven NAGLE, Anthia TOURE, Matthew SULLIVAN, Maya BERLIN-UDI, Lukas VASADI, Alexander STANGE, Sangkyun LEE, Stefanie MORGAN, Nick SEAY, Scott LURO
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Publication number: 20220282223Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: ApplicationFiled: March 7, 2022Publication date: September 8, 2022Inventors: Matthias WAGNER, Suvi AIVIO, Mariangela AMENDUNI, Catherine PILSMAKER, Arnaldo PEREIRA, Ananya ZUTSHI, Anthia TOURE, Steven NAGLE, Ozge WHITING, George HARB, Matthew SULLIVAN, Maya BERLIN-UDI, Stefanie MORGAN, Nick SEAY, Sang LEE, Scott LURO
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Publication number: 20220282201Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: ApplicationFiled: March 7, 2022Publication date: September 8, 2022Inventors: Matthias WAGNER, Suvi AIVIO, Mariangela AMENDUNI, Catherine PILSMAKER, Arnaldo PEREIRA, Ananya ZUTSHI, Anthia TOURE, Steven NAGLE, Ozge WHITING, George HARB, Matthew SULLIVAN, Maya BERLIN-UDI, Stefanie MORGAN, Nick SEAY, Sang LEE, Scott LURO
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Publication number: 20220282202Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: ApplicationFiled: March 7, 2022Publication date: September 8, 2022Inventors: Matthias WAGNER, Suvi AIVIO, Mariangela AMENDUNI, Catherine PILSMAKER, Arnaldo PEREIRA, Ananya ZUTSHI, Anthia TOURE, Steven NAGLE, Ozge WHITING, George HARB, Matthew SULLIVAN, Maya BERLIN-UDI, Stefanie MORGAN, Nick SEAY, Sang LEE, Scott LURO
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Publication number: 20220284574Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: ApplicationFiled: March 7, 2022Publication date: September 8, 2022Inventors: Matthias WAGNER, Suvi AIVIO, Mariangela AMENDUNI, Catherine PILSMAKER, Arnaldo PEREIRA, Ananya ZUTSHI, Anthia TOURE, Steven NAGLE, Ozge WHITING, George HARB, Matthew SULLIVAN, Maya BERLIN-UDI, Stefanie MORGAN, Nick SEAY, Sang LEE, Scott LURO
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Publication number: 20220282203Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.Type: ApplicationFiled: March 7, 2022Publication date: September 8, 2022Inventors: Matthias WAGNER, Suvi AIVIO, Mariangela AMENDUNI, Catherine PILSMAKER, Arnaldo PEREIRA, Ananya ZUTSHI, Anthia TOURE, Steven NAGLE, Ozge WHITING, George HARB, Matthew SULLIVAN, Maya BERLIN-UDI, Stefanie MORGAN, Nick SEAY, Sang LEE, Scott LURO
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Publication number: 20210403942Abstract: The disclosure relates to growing cells, directing cells to grow into specified cell types, genetically and physically manipulating cells, and addressing one or more individual cells within a mixed cell population. Aspects of the disclosure relate to vectors useful to induce developmental changes in cells, in which those vectors have a temporal component. Vectors of the disclosure encode a controllable, temporal series of events. Once the vectors are delivered into target cells, a series of discrete and different genetic events may be induced. The disclosed methods generally provide for the temporal encoding of multiplex genetic effectors in vector format for cell state transitions.Type: ApplicationFiled: November 5, 2019Publication date: December 30, 2021Inventors: Stan WANG, Suvi AIVIO, Matthias WAGNER, Catherine PILSMAKER, Marinna MADRID