Patents by Inventor Cathy Xiaoyan Zhong
Cathy Xiaoyan Zhong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230220407Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.Type: ApplicationFiled: January 25, 2023Publication date: July 13, 2023Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANYInventors: CLARA MARIA ALARCON, MATTHEW C. HARMON, M. ALEJANDRA PASCUAL, JAMES C. REGISTER, III, CHRISTOPHER J. SCELONGE, JOSHUA K. YOUNG, CATHY XIAOYAN ZHONG
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Publication number: 20230105029Abstract: An isolated monoclonal antibody that specifically binds human IL4R?, or an antigen-binding portion thereof. A nucleic acid molecule encoding the antibody or the antigen-binding portion thereof, an expression vector, a host cell and a method for expressing the antibody or the antigen-binding portion thereof are also provided. The present disclosure further provides a bispecific molecule, an oncolytic virus and a pharmaceutical composition comprising the antibody or the antigen-binding portion thereof, as well as a treatment method using an Anti-IL4R? antibody or the antigen-binding portion thereof of the disclosure.Type: ApplicationFiled: February 25, 2021Publication date: April 6, 2023Inventors: Mingjiu Chen, Wei Tan, Cathy Xiaoyan Zhong, Mark Zhiqing Ma, Shukai Xia, Zhengping Zhang, Hongjiang Xu, Zhijian Lu
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Publication number: 20230055711Abstract: An isolated monoclonal antibody that specifically binds human BCMA, or the antigen-binding portion thereof. The present disclosure further provides an immunoconjugate, a bispecific molecule, a chimeric antigen receptor, or an oncolytic virus comprising the antibody or the antigen-binding portion thereof, as well as a nucleic acid molecule encoding the same.Type: ApplicationFiled: December 29, 2020Publication date: February 23, 2023Inventors: Mingjiu CHEN, Wei TAN, Cathy Xiaoyan ZHONG, Shukai XIA
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Publication number: 20230034768Abstract: An isolated monoclonal antibody that specifically binds human RANKL, or the antigen-binding portion thereof. A nucleic acid molecule encoding the antibody or the antigen-binding portion thereof, an expression vector, a host cell and a method for expressing the antibody or the antigen-binding portion thereof are also provided. A treatment method using an anti-RANKL antibody or the antigen-binding portion is provided.Type: ApplicationFiled: December 11, 2020Publication date: February 2, 2023Inventors: Mingjiu CHEN, Cathy Xiaoyan ZHONG, Shukai XIA
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Publication number: 20220325295Abstract: Compositions and methods related to transgenic high oleic acid/ALS inhibitor-tolerant soybean plants are provided. Specifically, the present invention provides soybean plants having a DP-305423-1 event which imparts a high oleic acid phenotype and tolerance to at least one ALS-inhibiting herbicide. The soybean plant harboring the DP-305423-1 event comprises genomic/transgene junctions having at least the polynucleotide sequence of SEQ ID NO:8, 9, 14, 15, 20, 21, 83 or 84. The characterization of the genomic insertion site of the DP-305423-1 event provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the soybean DP-305423-1 events are provided.Type: ApplicationFiled: June 16, 2022Publication date: October 13, 2022Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: KENT BRINK, ROBERT F CRESSMAN, Jr., ANTHONY J KINNEY, KNUT MEYER, KEVIN L STECCA, NATALIE N WEBER, CATHY XIAOYAN ZHONG
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Publication number: 20220289833Abstract: Disclosed is an isolated monoclonal antibody that specifically binds human TSLP, or the antigen-binding portion thereof. A nucleic acid molecule encoding the antibody, an expression vector, a host cell and a method for expressing the antibody are also provided. The present disclosure further provides a bispecific molecule, an immunoconjugate, a CAR-immune cell, an oncolytic virus and a pharmaceutical composition comprising the antibody, as well as a treatment method using an anti-TSLP antibody of the disclosure.Type: ApplicationFiled: September 3, 2020Publication date: September 15, 2022Inventors: Mingjiu CHEN, Wei TAN, Cathy Xiaoyan ZHONG, Zhengping ZHANG, Xiaofang ZOU, Wei SONG, Hongjiang XU
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Patent number: 11390875Abstract: Compositions and methods related to transgenic high oleic acid/ALS inhibitor-tolerant soybean plants are provided. Specifically, the present invention provides soybean plants having a DP-305423-1 event which imparts a high oleic acid phenotype and tolerance to at least one ALS-inhibiting herbicide. The soybean plant harboring the DP-305423-1 event comprises genomic/transgene junctions having at least the polynucleotide sequence of SEQ ID NO:8, 9, 14, 15, 20, 21, 83 or 84. The characterization of the genomic insertion site of the DP-305423-1 event provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the soybean DP-305423-1 events are provided.Type: GrantFiled: July 13, 2020Date of Patent: July 19, 2022Inventors: Kent Brink, Robert F Cressman, Jr., Anthony J Kinney, Knut Meyer, Kevin L Stecca, Natalie N Weber, Cathy Xiaoyan Zhong
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Publication number: 20220002821Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.Type: ApplicationFiled: September 9, 2021Publication date: January 6, 2022Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANYInventors: SCOTT DIEHN, ALBERT L LU, TIMOTHY M NOWATZKI, DOUGLAS S NUBEL, M ALEJANDRA PASCUAL, JAMES C REGISTER, III, CHRISTOPHER J SCELONGE, JOSHUA K YOUNG, CATHY XIAOYAN ZHONG, ERIN L CROWGEY
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Patent number: 11155883Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.Type: GrantFiled: January 14, 2019Date of Patent: October 26, 2021Inventors: Scott Diehn, Albert L Lu, Timothy M Nowatzki, Douglas S Nubel, M Alejandra Pascual, James C Register, III, Christopher J Scelonge, Joshua K Young, Cathy Xiaoyan Zhong, Erin L Crowgey
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Publication number: 20200385749Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.Type: ApplicationFiled: August 19, 2020Publication date: December 10, 2020Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANYInventors: CLARA ALARCON, MATTHEW CURTIS HARMON, M. ALEJANDRA PASCUAL, JAMES C REGISTER, III, CHRISTOPHER J SCELONGE, JOSHUA K YOUNG, CATHY XIAOYAN ZHONG
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Publication number: 20200340005Abstract: Compositions and methods related to transgenic high oleic acid/ALS inhibitor-tolerant soybean plants are provided. Specifically, the present invention provides soybean plants having a DP-305423-1 event which imparts a high oleic acid phenotype and tolerance to at least one ALS-inhibiting herbicide. The soybean plant harboring the DP-305423-1 event comprises genomic/transgene junctions having at least the polynucleotide sequence of SEQ ID NO:8, 9, 14, 15, 20, 21, 83 or 84. The characterization of the genomic insertion site of the DP-305423-1 event provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the soybean DP-305423-1 events are provided.Type: ApplicationFiled: July 13, 2020Publication date: October 29, 2020Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: KENT BRINK, ROBERT F CRESSMAN, JR., ANTHONY J KINNEY, KNUT MEYER, KEVIN L STECCA, NATALIE N WEBER, CATHY XIAOYAN ZHONG
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Patent number: 10745711Abstract: Compositions and methods related to transgenic high oleic acid/ALS inhibitor-tolerant soybean plants are provided. Specifically, the present invention provides soybean plants having a DP-305423-1 event which imparts a high oleic acid phenotype and tolerance to at least one ALS-inhibiting herbicide. The soybean plant harboring the DP-305423-1 event comprises genomic/transgene junctions having at least the polynucleotide sequence of SEQ ID NO:8, 9, 14, 15, 20, 21, 83 or 84. The characterization of the genomic insertion site of the DP-305423-1 event provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the soybean DP-305423-1 events are provided.Type: GrantFiled: October 18, 2017Date of Patent: August 18, 2020Assignee: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Anthony J Kinney, Kent Brink, Robert F. Cressman, Jr., Knut Meyer, Kevin L. Stecca, Natalie N. Weber, Cathy Xiaoyan Zhong
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Publication number: 20190338300Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.Type: ApplicationFiled: July 19, 2019Publication date: November 7, 2019Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANYInventors: CLARA ALARCON, MATTHEW CURTIS HARMON, M. ALEJANDRA PASCUAL, JAMES C. REGISTER, III, CHRISTOPHER J SCELONGE, JOSHUA K. YOUNG, CATHY XIAOYAN ZHONG
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Patent number: 10407688Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.Type: GrantFiled: July 12, 2017Date of Patent: September 10, 2019Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E I DU PONT DE NEMOURS AND COMPANYInventors: Clara Maria Alarcon, Matthew C. Harmon, M. Alejandra Pascual, James C. Register, III, Christopher J. Scelonge, Joshua K. Young, Cathy Xiaoyan Zhong
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Publication number: 20190136331Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.Type: ApplicationFiled: January 14, 2019Publication date: May 9, 2019Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E.I. DU PONT DE NEMOURS AND COMPANYInventors: Scott Diehn, Albert L Lu, Timothy M Nowatzki, Douglas S Nubel, M Alejandra Pascual, James C Register, III, Christopher J Scelonge, Joshua K Young, Cathy Xiaoyan Zhong, Erin L Crowgey
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Patent number: 10190179Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.Type: GrantFiled: September 15, 2017Date of Patent: January 29, 2019Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E I DU PONT DE NEMOURS AND COMPANYInventors: Scott Diehn, Albert L. Lu, Timothy M. Nowatzki, Douglas S. Nubel, M. Alejandra Pascual, James C. Register, III, Christopher J. Scelonge, Joshua K. Young, Cathy Xiaoyan Zhong, Erin L. Crowgey
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Publication number: 20180030464Abstract: Compositions and methods related to transgenic high oleic acid/ALS inhibitor-tolerant soybean plants are provided. Specifically, the present invention provides soybean plants having a DP-305423-1 event which imparts a high oleic acid phenotype and tolerance to at least one ALS-inhibiting herbicide. The soybean plant harboring the DP-305423-1 event comprises genomic/transgene junctions having at least the polynucleotide sequence of SEQ ID NO:8, 9, 14, 15, 20, 21, 83 or 84. The characterization of the genomic insertion site of the DP-305423-1 event provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the soybean DP-305423-1 events are provided.Type: ApplicationFiled: October 18, 2017Publication date: February 1, 2018Inventors: ANTHONY J KINNEY, Kent Brink, Robert F. Cressman, Knut Meyer, Kevin L. Stecca, Natalie N. Weber, Cathy Xiaoyan Zhong
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Patent number: 9879327Abstract: Methods and compositions for detecting, identifying, and quantifying Brassica A genomic DNA are described. The methods are specific to the Brassica A genome and do not cross-react with other Brassica species, crops or weedy relatives that could contribute to contamination of a canola field.Type: GrantFiled: April 14, 2016Date of Patent: January 30, 2018Assignee: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Matthew Curtis Harmon, Nancy L Henderson, Cathy Xiaoyan Zhong
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Publication number: 20180023148Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.Type: ApplicationFiled: September 15, 2017Publication date: January 25, 2018Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANYInventors: SCOTT DIEHN, ALBERT L. LU, TIMOTHY M. NOWATZKI, DOUGLAS S. NUBEL, M. ALEJANDRA PASCUAL, JAMES C. REGISTER, III, CHRISTOPHER J. SCELONGE, JOSHUA K. YOUNG, CATHY XIAOYAN ZHONG, ERIN L. CROWGEY
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Publication number: 20170369953Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.Type: ApplicationFiled: July 12, 2017Publication date: December 28, 2017Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANYInventors: CLARA MARIA ALARCON, MATTHEW C. HARMON, M. ALEJANDRA PASCUAL, JAMES C. REGISTER, III, CHRISTOPHER J. SCELONGE, JOSHUA K. YOUNG, CATHY XIAOYAN ZHONG