Abstract: Systems and methods for removal of bacterial biofilm from a target site of a human patient includes a surgical instrument having an introducer for bodily insertion and maintaining an irrigation duct and a nozzle. A distal portion of the introducer is transitionable between a plurality of bend angles relative to a proximal portion thereof. In particular, the instrument is adapted to independently maintain the distal portion at each of the plurality of bend angles relative to the proximal portion. The nozzle is maintained relative to the distal portion of the introducer and is adapted to dispense pressurized irrigant from the irrigation duct toward a layer of bacterial biofilm.

Abstract: The invention provides a polymeric medical sealant for use in mammals other than humans. The medical sealant is useful for application to the tonsils, adenoids or paranasal sinus, wherein the sealant performs at least one of the following functions, a) inhibit the colonization of bacteria, b) inhibit the binding of bacteria to tissue, c) reduction of tissue morbidity, d) hemostasis, e) coating and protection of tissue during healing, f) promotion of healing, and g) reduction of pain.

Abstract: The invention provides a polymeric medical sealant. The medical sealant is useful for application to the tonsils and adenoids, wherein the sealant performs at least one of the following functions, a) inhibit the colonization of bacteria, b) inhibit the binding of bacteria to tissue, c) reduction of tissue morbidity, d) hemostasis, e) coating and protection of tissue during healing. f) promotion of healing, and g) reduction of pain.

Abstract: Systems and methods of removing bacterial biofilm from a target site using a biofilm removal endoscope. The endoscope has an insertion portion including an imaging channel terminating at a viewing window and an irrigation channel terminating at a nozzle. The imaging and irrigation channels are permanently affixed relative to one another. The insertion portion is inserted into the patient, with a working end thereof being disposed proximate the target site. The target site is imaged and a flow of fluid is dispensed via the nozzle to mechanically remove bacterial biofilm from the target site.

Abstract: A surgical micro-burring instrument including an outer tubular member coaxially maintaining an inner tubular member. The outer tubular member defines a proximal section, a distal section, and a central lumen extending from the proximal section to the distal section. The distal section forms a pocket and an elevator tip. The pocket has a bottom wall and an opposed upper opening. The elevator tip extends distal the pocket. The inner tubular member forms a bur received within the pocket. Upon final assembly, at least a portion of the bur is exposed relative to the outer tubular member via the upper opening of the pocket. The elevator tip is configured to facilitate lifting of soft tissue, such as mucosa, while positioning the bur, via the pocket, in an appropriate location for cutting contacted harder tissue, such as turbinate bone or septal bone/cartilage.

Abstract: Systems and methods of removing bacterial biofilm from a target site using a biofilm removal endoscope. The endoscope has an insertion portion including an imaging channel terminating at a viewing window and an irrigation channel terminating at a nozzle. The imaging and irrigation channels are permanently affixed relative to one another. The insertion portion is inserted into the patient, with a working end thereof being disposed proximate the target site. The target site is imaged and a flow of fluid is dispensed via the nozzle to mechanically remove bacterial biofilm from the target site.

Abstract: The invention provides a polymeric medical sealant. The medical sealant is useful for application to the tonsils and adenoids, wherein the sealant performs at least one of the following functions, a) inhibit the colonization of bacteria, b) inhibit the binding of bacteria to tissue, c) reduction of tissue morbidity, d) hemostasis, e) coating and protection of tissue during healing. f) promotion of healing, and g) reduction of pain.

Abstract: Systems and methods of removing bacterial biofilm from a target site using a biofilm removal endoscope. The endoscope has an insertion portion including an imaging channel terminating at a viewing window and an irrigation channel terminating at a nozzle. The imaging and irrigation channels are permanently affixed relative to one another. The insertion portion is inserted into the patient, with a working end thereof being disposed proximate the target site. The target site is imaged and a flow of fluid is dispensed via the nozzle to mechanically remove bacterial biofilm from the target site.

Abstract: A method for performing a surgical procedure on tissue at a target site of a patient includes providing a surgical cutting instrument including an outer tube, inner wire assembly and a cutting tip. The outer tube defines a curved segment. The inner wire assembly is rotatably disposed within the outer tube. The cutting tip is connected to the inner wire assembly and positioned at a distal end of the outer tube. The tissue at the target site is exposed and the cutting tip is deployed against the tissue. The method further includes rotating the inner wire assembly relative to the outer tube at speeds in excess of 50,000 RPM such that the cutting tip removes contacted tissue.

Abstract: The invention provides a polymeric film-forming medical sealant. The medical sealant is useful for application to the tonsils and adenoids, wherein the sealant performs at least one of the following functions, a) inhibit the colonization of bacteria, b) inhibit the binding of bacteria to tissue, c) reduction of tissue morbidity, d) hemostasis, e) coating and protection of tissue during healing. e) promotion of healing, and f) reduction of pain.

Abstract: Chronic rhinosinusitis and other bacterial sinus conditions may be treated by applying a solvating system containing a surfactant to a bacterial biofilm in a nasal or sinus cavity, disrupting the biofilm, and applying a protective layer of a polymeric film-forming medical sealant.

Abstract: Chronic otitis media and other bacterial ear conditions may be treated by applying a solvating system containing a metal ion sequestering agent and surfactant to a bacterial biofilm in the middle or inner ear. The solvating system disrupts the biofilm and aids in its removal.

Abstract: Chronic Otitis Media with Effusion (COME), Recurrent Acute Otitis Media (RAOM), cholesteatoma, and other bacterial ear conditions may be treated by applying a solvating system containing greater than 0.2 wt. % surfactant to a bacterial biofilm in the middle or inner ear, disrupting the biofilm, and applying a protective layer of a polymeric film-forming medical sealant.

Abstract: A method of removing bacterial biofilm from a target site of a human patient. A bacterial biofilm removal system is provided that includes an endoscope, an irrigation duct and an aspiration duct. The endoscope includes a working end. The irrigation duct includes an outlet. The aspiration duct includes an inlet. The endoscope working end, the irrigation duct outlet and the aspiration duct inlet are disposed proximate a target site that includes a layer of bacterial biofilm. The target site is imaged with the endoscope working end. The fluid is dispensed through the irrigation duct outlet toward the target site to mechanically remove at least a portion of the layer of bacterial biofilm. The removed bacterial biofilm and the dispensed fluid are collected with the aspiration duct inlet.

Abstract: A surgical micro-burring instrument including an outer tubular member coaxially maintaining an inner tubular member. The outer tubular member defines a proximal section, a distal section, and a central lumen extending from the proximal section to the distal section. The distal section forms a pocket and an elevator tip. The pocket has a bottom wall and an opposed upper opening. The elevator tip extends distal the pocket. The inner tubular member forms a bur received within the pocket. Upon final assembly, at least a portion of the bur is exposed relative to the outer tubular member via the upper opening of the pocket. The elevator tip is configured to facilitate lifting of soft tissue, such as mucosa, while positioning the bur, via the pocket, in an appropriate location for cutting contacted harder tissue, such as turbinate bone or septal bone/cartilage.

Abstract: A surgical micro-burring instrument including an outer tubular member coaxially maintaining an inner tubular member. The outer tubular member defines a proximal section, a distal section, and a central lumen extending from the proximal section to the distal section. The distal section forms a pocket and an elevator tip. The pocket has a bottom wall and an opposed upper opening. The elevator tip extends distal the pocket. The inner tubular member forms a bur received within the pocket. Upon final assembly, at least a portion of the bur is exposed relative to the outer tubular member via the upper opening of the pocket. The elevator tip is configured to facilitate lifting of soft tissue, such as mucosa, while positioning the bur, via the pocket, in an appropriate location for cutting contacted harder tissue, such as turbinate bone or septal bone/cartilage.

Abstract: A method for performing a surgical procedure on tissue at a target site of a patient includes providing a surgical cutting instrument including an outer tube, inner wire assembly and a cutting tip. The outer tube defines a curved segment. The inner wire assembly is rotatably disposed within the outer tube. The cutting tip is connected to the inner wire assembly and positioned at a distal end of the outer tube. The tissue at the target site is exposed and the cutting tip is deployed against the tissue. The method further includes rotating the inner wire assembly relative to the outer tube at speeds in excess of 50,000 RPM such that the cutting tip removes contacted tissue.

Abstract: A surgical cutting instrument including an outer tube, inner wire assembly, cutting tip, coupling chuck, and housing. The outer tube includes a lumen extending from a proximal end to a distal end. The inner wire assembly is received within the lumen. Preferably, the outer tube and inner wire assembly form a longitudinally curved segment. The cutting tip is connected to a distal section of the inner wire assembly. The coupling chuck is secured to a proximal section of the inner wire assembly. The housing maintains the outer tube and the coupling chuck. A rotating journal bearing, preferably a rotating-hydrodynamic bearing, is established between the inner wire assembly and the inner surface of the outer tube, allowing nominal rotational speeds of 80,000 RPM. Preferred embodiments of the surgical cutting instrument enhance surgeon visibility, minimize heat build-up, and provide improved stiffness and thermal protection.

Abstract: Systems and methods for removal of bacterial biofilm from a target site of a human patient includes a surgical instrument having an introducer for bodily insertion and maintaining an irrigation duct and a nozzle. A distal portion of the introducer is transitionable between a plurality of bend angles relative to a proximal portion thereof. In particular, the instrument is adapted to independently maintain the distal portion at each of the plurality of bend angles relative to the proximal portion. The nozzle is maintained relative to the distal portion of the introducer and is adapted to dispense pressurized irrigant from the irrigation duct toward a layer of bacterial biofilm.

Abstract: Systems and methods of removing bacterial biofilm from a target site using a biofilm removal endoscope. The endoscope has an insertion portion including an imaging channel terminating at a viewing window and an irrigation channel terminating at a nozzle. The imaging and irrigation channels are permanently affixed relative to one another. The insertion portion is inserted into the patient, with a working end thereof being disposed proximate the target site. The target site is imaged and a flow of fluid is dispensed via the nozzle to mechanically remove bacterial biofilm from the target site.