Patents by Inventor Cecile Jaravel
Cecile Jaravel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7214529Abstract: An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification reagent (e.g., primers and nucleotides) and a second reaction chamber either containing, or in fluid communication, with a second nucleic acid amplification reagent (e.g., an amplification enzyme such as RT). The instrument includes a support structure receiving the test device. A temperature control system maintains the first reaction chamber at a first elevated temperature but simultaneously maintains the second nucleic acid amplification reagent at a second temperature lower than the first temperature so as to preserve the second nucleic acid amplification reagent. An actuator operates on a fluid conduit in the test device to place the first and second reaction chambers in fluid communication with each other after a reaction has occurred in the first reaction chamber at the first temperature.Type: GrantFiled: July 12, 2005Date of Patent: May 8, 2007Assignee: bioMérieux, Inc.Inventors: Bryan W. Kluttz, Geoff A. McKinley, Fabio Gennari, Michel Guy, Christopher Cotter, Luigi Catanzariti, Louis Graziano, Bruno Colin, Cecile Jaravel, Jacques Dachaud
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Patent number: 7097623Abstract: A method for drawing a biological sample using a suction-discharge device, such as a manual or automatic pipette, built into an automated device or not. A method for detecting the free surface of a biological sample and/or solid, a sample drawing device such as a pipette and a device for detecting the free surface of a biological sample or a solid are also disclosed. This method includes actuating a means causing a pressure variation or an air flow within the suction-discharge device, positioning the lower free end of the device in such a way so that it becomes flush with a free surface of the biological sample, measuring an overpressure within the suction-discharge device, and sampling a quantity of the sample by suction using the device. The invention finds a preferable application in the field of automatic analyzers.Type: GrantFiled: August 14, 2003Date of Patent: August 29, 2006Assignee: Biomerieux S.A.Inventors: Bruno Colin, Cécile Jaravel, Marie Privat
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Publication number: 20050244887Abstract: An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification reagent (e.g., primers and nucleotides) and a second reaction chamber either containing, or in fluid communication, with a second nucleic acid amplification reagent (e.g., an amplification enzyme such as RT). The instrument includes a support structure receiving the test device. A temperature control system maintains the first reaction chamber at a first elevated temperature but simultaneously maintains the second nucleic acid amplification reagent at a second temperature lower than the first temperature so as to preserve the second nucleic acid amplification reagent. An actuator operates on a fluid conduit in the test device to place the first and second reaction chambers in fluid communication with each other after a reaction has occurred in the first reaction chamber at the first temperature.Type: ApplicationFiled: July 12, 2005Publication date: November 3, 2005Applicant: bioMerieux, Inc.Inventors: Bryan Kluttz, Geoff McKinley, Fabio Gennari, Michel Guy, Christopher Cotter, Luigi Catanzariti, Louis Graziano, Bruno Colin, Cecile Jaravel, Jacques Dachaud
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Patent number: 6949376Abstract: An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification reagent (e.g., primers and nucleotides) and a second reaction chamber either containing, or in fluid communication, with a second nucleic acid amplification reagent (e.g., an amplification enzyme such as RT). The instrument includes a support structure receiving the test device. A temperature control system maintains the first reaction chamber at a first elevated temperature but simultaneously maintains the second nucleic acid amplification reagent at a second temperature lower than the first temperature so as to preserve the second nucleic acid amplification reagent. An actuator operates on a fluid conduit in the test device to place the first and second reaction chambers in fluid communication with each other after a reaction has occurred in the first reaction chamber at the first temperature.Type: GrantFiled: May 7, 2002Date of Patent: September 27, 2005Assignee: bioMerieux, Inc.Inventors: Bryan W. Kluttz, Geoff A. McKinley, Fabio Gennari, Michel Guy, Christopher Cotter, Luigi Catanzariti, Louis Graziano, Bruno Colin, Cecile Jaravel, Jacques Dachaud
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Publication number: 20040048393Abstract: A method for drawing a biological sample using a suction-discharge device, such as a manual or automatic pipette, built into an automated device or not. A method for detecting the free surface of a biological sample and/or solid, a sample drawing device such as a pipette and a device for detecting the free surface of a biological sample or a solid are also disclosed. This method includes actuating a means causing a pressure variation or an air flow within the suction-discharge device, positioning the lower free end of the device in such a way so that it becomes flush with a free surface of the biological sample, measuring an overpressure within the suction-discharge device, and sampling a quantity of the sample by suction using the device. The invention finds a preferable application in the field of automatic analyzers.Type: ApplicationFiled: August 14, 2003Publication date: March 11, 2004Inventors: Bruno Colin, Cecile Jaravel, Marie Privat
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Patent number: 6641545Abstract: A method for drawing a biological sample using a suction-discharge device, such as a manual or automatic pipette, built into an automated device or not. A method for detecting the free surface of a biological sample and/or solid, a sample drawing device such as a pipette and a device for detecting the free surface of a biological sample or a solid are also disclosed. This method includes actuating a means causing a pressure variation or an air flow within the suction-discharge device, positioning the lower free end of the device in such a way so that it becomes flush with a free surface of the biological sample, measuring an overpressure within the suction-discharge device, and sampling a quantity of the sample by suction using the device. The invention finds a preferable application in the field of automatic analyzers.Type: GrantFiled: September 29, 2000Date of Patent: November 4, 2003Assignee: Biomerieux S.A.Inventors: Bruno Colin, Cécile Jaravel, Marie Privat
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Patent number: 6589790Abstract: Device for filling, with a liquid medium (1), an analysis card (2) comprising a body (3) in which at least one reading cavity (3a) is formed, and an orifice (4) communicating with the cavity via at least one internal channel (7), with an external conduit (9) communicating with the orifice, this device comprising an evacuation device (50). It comprises: a connecting device (11) including on one side a joining piece (12) for leaktight and removable coupling to the free end (9a) of the open external conduit, and communicating directly on the other side with the evacuation device (50); a device (34) for closing and re-opening the external conduit.Type: GrantFiled: December 2, 1998Date of Patent: July 8, 2003Assignee: Bio MerieuxInventors: Bruno Colin, Cécile Jaravel
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Patent number: 6429007Abstract: An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification reagent (e.g., primers and nucleotides) and a second reaction chamber either containing, or in fluid communication, with a second nucleic acid amplification reagent (e.g., an amplification enzyme such as RT). The instrument includes a support structure receiving the test device. A temperature control system maintains the first reaction chamber at a first elevated temperature but simultaneously maintains the second nucleic acid amplification reagent at a second temperature lower than the first temperature so as to preserve the second nucleic acid amplification reagent. An actuator operates on a fluid conduit in the test device to place the first and second reaction chambers in fluid communication with each other after a reaction has occurred in the first reaction chamber at the first temperature.Type: GrantFiled: October 18, 1999Date of Patent: August 6, 2002Assignee: bioMérieux, Inc.Inventors: Bryan W. Kluttz, Geoff A. McKinley, Fabio Gennari, Michel Guy, Christopher Cotter, Luigi Catanzariti, Louis Graziano, Bruno Colin, Cecile Jaravel, Jacques Dachaud
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Patent number: 6263743Abstract: A device for transferring a liquid sample drawn by suction, through a wall having an orifice, the device including a conduit, a plunger sealingly sliding in the conduit, and a rod controlling the plunger. The device includes a joining piece extending the conduit, with an outer cross-section adapted to fit in the aperture, for example sealing it, with close working clearance required for inserting the joining piece in the orifice, the joining piece being arranged to be separated from the conduit once it is engaged in the orifice, and to seal the orifice, when or once the joining piece engaged in the orifice is separated from the conduit.Type: GrantFiled: December 18, 1998Date of Patent: July 24, 2001Assignee: Bio MerieuxInventors: Bruno Colin, Cécile Jaravel
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Patent number: 6015531Abstract: The invention features an analysing device (1) comprising a body (2) in which are arranged or provided: an intake aperture (3) for a starting liquid sample, a liquid flow circuit (5) comprising at least one operating cell (6) for a processed liquid sample, obtained from all or part of the original sample, communicating with the said intake aperture (3), the said flow circuit defining, in at least two dimensions of the card, one determined geometric line, such that any alteration in the card orientation in a three-dimensional reference frame, causes the liquid to flow under gravity only, from one part of the said circuit to another,for instance from one side or another of the operating cell, (6) characterised in that, the flow circuit (5) is continuous, and looped on itself between the said aperture (3) and the said operating cell (6).Type: GrantFiled: March 5, 1998Date of Patent: January 18, 2000Assignee: Bio MerieuxInventors: Bruno Colin, Cecile Jaravel, Philippe Cleuziat
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Patent number: 5989499Abstract: A reaction vessel for a nucleic acid amplification reaction has a first chamber containing an amplification reagent mix, a second chamber containing an amplification enzyme, and a fluid channel or chamber connecting the first and second chambers together. A fluid sample is introduced into the first chamber. After a denaturation and primer annealing process has occurred in the first chamber, the fluid channel is opened to allow the solution of the reagent and fluid sample to flow into the second chamber. The second chamber is maintained at an optimal temperature for the amplification reaction.A station is described for processing test strips incorporating the reaction vessels. The station includes temperature and vacuum control subsystems to maintain proper temperatures in the reaction vessel and effectuate the transfer of the fluid from one chamber to the other in an autlomated fashion without human intervention.Type: GrantFiled: April 2, 1998Date of Patent: November 23, 1999Assignee: bioMerieux, Inc.Inventors: Luigi Catanzariti, Bryan W. Kluttz, Bruno Colin, Cecile Jaravel