Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Abstract: The present disclosure provides a kit and method for constructing a long-acting depression animal model. The present disclosure adopts Bacille Calmette-Guerin (BCG) (or Mycobacterium bovis (M bovis)) and low-dose pertussis toxin (PTX) for combined induction, which greatly reduces modeling cost. A mouse model constructed by the method of the present disclosure can clearly distinguish a time interval of pathological behaviors from a time interval of depression-like behaviors and has prominent face validity and predictive validity. The method of the present disclosure is simple and convenient and does not require a large number of tedious daily operations as the depression model construction by chronic unpredictable stress, chronic restraint stress, social defeat, mother-child separation, or the like. The mouse model of the present disclosure can provide a valuable long-term intervention window for research on antidepressant therapy.

Abstract: A silicon-based particle with a core-shell structure, a method for preparing the same, an anode material, an electrode and a battery. The silicon-based particle includes: a core comprising an oxygen-containing silicon-based compound matrix and nano-silicon grains, a molar ratio of oxygen to silicon in the core being 0.5-1.5; a silicon carbide layer covering the core; and a carbon layer covering the silicon carbide layer. The silicon-based particle is used in batteries, and has the characteristics of low expansion rate, long cycle life, high capacity and high coulombic efficiency.

Abstract: An anode active material for batteries includes anode active substance particles. The anode active substance particles include silicon oxide compound particles including nano-silicon grains and lithium; and a composite oxide coating layer partially or entirely covering the silicon oxide compound particles and containing a composite oxide of a metal M and phosphorus, where the metal M includes lithium and a non-lithium metal. The anode active material has good water tolerance. A battery prepared from the anode active material has at least the advantages of good cycle performance, high energy density, high coulombic efficiency, good rate performance, and the like.

Abstract: A method of rendering an object is provided. The method comprises: encoding a feature vector to each point in a point cloud for an object, wherein the feature vector comprises an alpha matte; projecting each point in the point cloud and the corresponding feature vector to a target view to compute a feature map; and using a neural rendering network to decode the feature map into a RGB image and the alpha matte and to update the feature vector.

Abstract: A method of rendering an object is provided. The method comprises: encoding a feature vector to each point in a point cloud for an object, wherein the feature vector comprises an alpha matte; projecting each point in the point cloud and the corresponding feature vector to a target view to compute a feature map; and using a neural rendering network to decode the feature map into a RGB image and the alpha matte and to update the feature vector.

Abstract: An anode active material for batteries including anode active substance particles that include a silicon oxide compound. The anode active substance particles includes lithium and a non-lithium doping metal, where the non-lithium doping metal includes a metal M1 including one or more of titanium, magnesium, zirconium, zinc, aluminum, yttrium and calcium, and the content of the non-lithium doping metal in the anode active material is 0.01-20 wt %, for example 0.05-15 wt %, in another example 0.1-10 wt %, and in still another example 0.1-5 wt %. The anode active material has high water tolerance, and a secondary battery prepared from the anode active material has the advantages of high capacity, high coulombic efficiency and long cycle life.

Abstract: A silicon oxide particle for an electrode material, including: silicon suboxide particles with a general formula of SiOx; and a carbon layer, where a plurality of silicon suboxide particles are bonded by the carbon layer, and the plurality of silicon suboxide particles are bonded and meanwhile coated by the carbon layer. The silicon oxide particle is dense, with narrow particle size distribution and small specific surface area, and has advantages such as high capacity, high Coulombic efficiency, low swelling rate and high capacity retention.