Abstract: An immune gene expression signature is associated with favorable clinical features in Treg-enriched tumor samples and can be used to predict immunogenicity of a tumor, overall survival, and/or chemosensitivity.

Abstract: An immune gene expression signature is associated with favorable clinical features in Treg-enriched tumor samples and can be used to predict immunogenicity of a tumor, overall survival, and/or chemosensitivity.

Abstract: A pre-swirler unit can include: a shroud including a bottom surface and a top surface opposite to the bottom surface; a blade disposed on the top surface and including a leading edge and a trailing edge, wherein the blade comprises a concave side surface and a convex side surface that are disposed between the leading edge and the trailing edge, wherein the convex side surface comprises a first plurality of dimples, and wherein the concave side surface comprises a second plurality of dimples.

Abstract: A compressor blade of a gas turbine includes a compressor blade portion including a plurality of layers; and a carbon fiber reinforcement embedded in the plurality of layers of the compressor blade portion and oriented in a direction of stress fields of the compressor blade when in operation. A method of manufacturing the compressor blade includes preparing a composite material including fiber-reinforced layers; forming a first layer of the composite material to extend in a radial direction of the compressor blade; and stacking a second layer of the composite material on the first layer in an axial direction of the compressor blade. The compressor blade is 3D-printed by forming each composite material layer in a radial direction, which layers are stacked in an axial direction. Fiber reinforcement in the composite compressor blade is oriented in line with the stress fields inherent in the operation of the compressor blade.

Abstract: A compressor blade of a gas turbine includes a root member; an airfoil that is disposed on the root member and includes a first interior wall and a second interior wall forming a hollow space defined between the first and second interior walls; and an organic vibration stiffener (OVS) formed on at least one of the first interior wall and the second interior wall. The OVS is formed by 3D printing performed with respect to a surface of the at least one of the first interior wall and the second interior wall and includes an uneven surface formed on at least part of the at least one of the first interior wall and the second interior wall. The OVS may include a protruded or recessed portion protruding from or recessed into at least part of the at least one of the first interior wall and the second interior wall.

Abstract: A turbine blade can include: a root; a platform disposed on the root; an airfoil disposed on the platform and including a leading edge and a trailing edge; and an additive trailing edge disposed on the trailing edge of the airfoil, wherein a first material of the trailing edge of the airfoil is different from a second material of the additive trailing edge, and wherein a first radius of the trailing edge is larger than a second radius of the additive trailing edge.

Abstract: A compressor blade of a gas turbine includes a compressor blade portion including a plurality of layers; and a carbon fiber reinforcement embedded in the plurality of layers of the compressor blade portion and oriented in a direction of stress fields of the compressor blade when in operation. A method of manufacturing the compressor blade includes preparing a composite material including fiber-reinforced layers; forming a first layer of the composite material to extend in a radial direction of the compressor blade; and stacking a second layer of the composite material on the first layer in an axial direction of the compressor blade. The compressor blade is 3D-printed by forming each composite material layer in a radial direction, which layers are stacked in an axial direction. Fiber reinforcement in the composite compressor blade is oriented in line with the stress fields inherent in the operation of the compressor blade.

Abstract: A compressor blade of a gas turbine includes a root member; an airfoil that is disposed on the root member and includes a first interior wall and a second interior wall forming a hollow space defined between the first and second interior walls; and an organic vibration stiffener (OVS) formed on at least one of the first interior wall and the second interior wall. The OVS is formed by 3D printing performed with respect to a surface of the at least one of the first interior wall and the second interior wall and includes an uneven surface formed on at least part of the at least one of the first interior wall and the second interior wall. The OVS may include a protruded or recessed portion protruding from or recessed into at least part of the at least one of the first interior wall and the second interior wall.

Abstract: An immune gene expression signature is associated with favorable clinical features in Treg-enriched tumor samples and can be used to predict immunogenicity of a tumor, overall survival, and/or chemosensitivity.

Abstract: A strut shield collar can include: a tubular portion including a tubular inside surface and a tubular outside surface; a flange portion extended from the tubular portion toward an outside of the tubular portion and including a flange inside surface; and a grid type mesh formed on at least one of the tubular inside surface and the flange inside surface, wherein the grid type mesh comprises a groove portion and a rib portion, and the groove portion is thinner than the rib portion.

Abstract: Improved accuracy of SNV-based genetic tests is performed using DNA sequencing data from a tumor sample and a matched normal sample to determine SNVs, and RNA sequencing data from the tumor sample are used to ascertain expression of so identified SNVs.

Abstract: A pre-swirler unit can include: a shroud including a bottom surface and a top surface opposite to the bottom surface; a blade disposed on the top surface and including a leading edge and a trailing edge, wherein the blade comprises a concave side surface and a convex side surface that are disposed between the leading edge and the trailing edge, wherein the convex side surface comprises a first plurality of dimples, and wherein the concave side surface comprises a second plurality of dimples.

Abstract: An inter stage seal housing for a turbine engine having upper and lower half inter stage seal housings in which a contact sealing surface of the seal housing is restored after an interval of engine operation. The contact sealing surface is restored by fitting a replaceable wear strip on the downstream sealing surface of the seal housing. In order to fit the replaceable wear strip, a circumferential groove is machined along an outer peripheral edge of the seal housing. The groove is machined to include axial location and radial retention such that the wear strips can be slid into the upper half and lower half inter stage seal housing circumferentially from the horizontal joint. The groove includes through holes and the wear strips include corresponding threaded holes such that the wear strips can be fastened in the groove by fasteners and fastener retention hardware.

Abstract: Compositions, methods, and uses of de novo pyrimidine synthesis pathway element, CAD, and optionally a second gene in a nucleotide excision repair pathway, POLD2 in determining a predicted survival rate, predicted responsiveness to a cisplatin-based chemotherapy of a patient diagnosed with bladder urothelial carcinoma are provided.

Abstract: A turbine blade can include: a root; a platform disposed on the root; an airfoil disposed on the platform and including a leading edge and a trailing edge; and an additive trailing edge disposed on the trailing edge of the airfoil, wherein a first material of the trailing edge of the airfoil is different from a second material of the additive trailing edge, and wherein a first radius of the trailing edge is larger than a second radius of the additive trailing edge.

Abstract: A strut shield collar can include: a tubular portion including a tubular inside surface and a tubular outside surface; a flange portion extended from the tubular portion toward an outside of the tubular portion and including a flange inside surface; and a grid type mesh formed on at least one of the tubular inside surface and the flange inside surface, wherein the grid type mesh comprises a groove portion and a rib portion, and the groove portion is thinner than the rib portion.

Abstract: An inter stage seal housing for a turbine engine having upper and lower half inter stage seal housings in which a contact sealing surface of the seal housing is restored after an interval of engine operation. The contact sealing surface is restored by fitting a replaceable wear strip on the downstream sealing surface of the seal housing. In order to fit the replaceable wear strip, a circumferential groove is machined along an outer peripheral edge of the seal housing. The groove is machined to include axial location and radial retention such that the wear strips can be slid into the upper half and lower half inter stage seal housing circumferentially from the horizontal joint. The groove includes through holes and the wear strips include corresponding threaded holes such that the wear strips can be fastened in the groove by fasteners and fastener retention hardware.

Abstract: An inter stage seal housing for a turbine engine having upper and lower half inter stage seal housings in which a contact sealing surface of the seal housing is restored after an interval of engine operation. The contact sealing surface is restored by fitting a replaceable wear strip on the downstream sealing surface of the seal housing. In order to fit the replaceable wear strip, a circumferential groove is machined along an outer peripheral edge of the seal housing. The groove is machined to include axial location and radial retention such that the wear strips can be slid into the upper half and lower half inter stage seal housing circumferentially from the horizontal joint. The groove includes through holes and the wear strips include corresponding threaded holes such that the wear strips can be fastened in the groove by fasteners and fastener retention hardware.

Abstract: An inter stage seal housing for a turbine engine having upper and lower half inter stage seal housings in which a contact sealing surface of the seal housing is restored after an interval of engine operation. The contact sealing surface is restored by fitting a replaceable wear strip on the downstream sealing surface of the seal housing. In order to fit the replaceable wear strip, a circumferential groove is machined along an outer peripheral edge of the seal housing. The groove is machined to include axial location and radial retention such that the wear strips can be slid into the upper half and lower half inter stage seal housing circumferentially from the horizontal joint. The groove includes through holes and the wear strips include corresponding threaded holes such that the wear strips can be fastened in the groove by fasteners and fastener retention hardware.

Abstract: A blade assembly (10) for a turbine (16) including a vibration damper (12) having a mounting base (38) sealingly disposed at an inlet end (24) of a cooling fluid passageway (22) within the root section (20) of the blade assembly and including an opening (40) in the mounting base for passing cooling fluid into the cooling passageway. The opening is sized to function effectively as an orifice for limiting a maximum flow rate of cooling fluid in the event of a breach of the cooling fluid passageway downstream of the inlet end. A wear feature (34) is formed on the distal end of the vibration damper opposed the mounting base for rubbing interface with a complementary wear feature attached to a wall (26) of the cooling fluid passageway. The wear feature may include a non-planar wear surface such as angularly disposed wear surfaces (58, 60) effective to resist vibrational movement in two directions.