Abstract: Systems and methods for laser beam welding in a vacuum and for controlling laser beam welding processes, such as for use in manufacturing aerospace parts, are described herein. In some embodiments, a laser beam welding system can include an optical head movably positioned within a vacuum chamber. The optical head can be configured to direct a laser beam toward a part positioned within the vacuum chamber to melt and fuse the part.

Abstract: The disclosure relates to the inherently selective mixed oxide deposition of a dielectric film on non-metallic substrates without concomitant growth on metallic substrates using a sequence of exposure to metal alkyl, heteroatom silacyclic compound, and water. The resulting films show much higher growth rates than corresponding metal oxide and inherent selectivity towards non-metallic surfaces. Films as thick as 14 nm can be grown on dielectric substrates such as thermal oxide and silicon nitride without any growth observed on metallic films such as copper and without the use of an inhibitor. Such dielectric-on-dielectric (DoD) growth is a critical element of many proposed fabrication schemes for future semiconductor device fabrication such as fully self-aligned vias.

Abstract: The invention relates to COnditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure to tumor proteases, the constructs are cleaved and activated, such that they can bind one or more tumor target antigens (TTAs) as well as CD3, thus recruiting T cells expressing CD3 to the tumor, resulting in treatment. In some embodiments, the tumor target antigen includes B7H3, CA9 (CAIX), EGFR, EpCAM, FOLR1, HER2, LyPD3, and/or Trop2.

Abstract: The selective deposition of a metal oxide or dielectric layer on non-metallic substrates without concomitant growth on metallic substrates using cyclic azasilanes, cyclic thiasilanes, or cyclic tellurasilanes to inhibit growth on the metal surface is described. Films over seven nanometers thick can be grown on dielectric substrates, such as thermal silicon dioxide and silicon, without any growth observed on metallic areas such as copper. Such dielectric-on-dielectric (DoD) growth is a critical element of many proposed fabrication schemes for future semiconductor device fabrication such as fully self-aligned vias.

Abstract: A compensating fastener assembly is configured to secure a fastener to a surface element. The compensating fastener assembly includes a compression limiter having a cylindrical main body and a flange, the cylindrical main body defining a channel and a longitudinal axis. The compensating fastener assembly further includes a spring defining a central passage. The central passage of the spring is configured to receive the main body of the compression limiter such that a first end of the spring is configured to be disposed adjacent the flange of the compression limiter.

Abstract: Amine functionalized nanoparticles comprising a core-shell nanoparticle morphology comprising a trialkoxyorganosilane coated nanoparticle core and an amine functionalized group on the surface of the nanoparticle as a shell are disclosed, wherein the nanoparticle has an average particle size from about 1 nm to about 1000 nm. Methods and applications of use of the amine functionalized nanoparticles and compositions comprising the amine functionalized nanoparticles dispersed in an aqueous medium are also disclosed.

Abstract: A domestic appliance includes a cabinet forming a receiving space; a control panel attached to the cabinet, the control panel including one or more control inputs; a wireless transmitter provided within the control panel to emit a signal; a wireless communication module provided within the control panel, the wireless communication module establishing a wireless connection between the appliance and a remote terminal; and a controller provided within the control panel, the controller being configured to perform a series of operations. The series of operations includes emitting, via the first wireless communication module, the signal, wherein the signal contains a predetermined code to identify the domestic appliance and retrieve an input sequence for altering an operational mode of the domestic appliance.

Abstract: A product flow splitter is used to distribute agricultural product from a distribution line to a primary hopper and a secondary hopper. The splitter has an inlet segment, a primary outlet segment, and a secondary outlet segment. The inlet segment receives the agricultural product from the distribution line, the primary outlet segment outputs the agricultural product to the primary hopper, and the secondary outlet segment outputs the agricultural product to the secondary hopper. The primary outlet segment is aligned with the inlet segment along a common axis and the secondary outlet segment is curved to avoid plugging of the agricultural product in the product flow splitter. The primary outlet segment is positioned relative to the primary hopper so that an outlet of the primary outlet segment in the primary hopper is offset from an outlet of the primary hopper to a meter system to solve an overfilled situation.

Abstract: Shipping system for temperature-sensitive materials. In one embodiment, the shipping system may include an insulated container. The insulated container may include a frame surrounding a payload space, the frame including a door providing access to the payload space. The shipping system may additionally include a door brace assembly. The door brace assembly may be mounted within the payload space just inside the door and may include a door plug configured to substantially close the payload space. The door brace assembly may additionally include a door brace mounted within the door plug. The door brace may be transformable between a retracted state and an expanded state. When in its retracted state, the door brace assembly may be loaded into or removed from the insulated container. When in its expanded state, the door brace assembly engages the four corners of the frame just inside the door to keep the frame square.

Abstract: An appliance includes a wireless communication module in wireless communication with a remote server through an external network and a controller operably coupled to the wireless communication module. A method of ensuring that the appliance is using the latest operating software includes detecting a software verification trigger (such as the replacement or maintenance of a control board), obtaining a current software version and a latest software version, determining that the current and latest software versions do not match, and initiating a software update process to update the controller to the latest software version.

Abstract: A plugging device for use in multistage fracturing a subterranean formation. The plugging device includes a plug body having a distal end, a proximate end, and an outer surface. There are a plurality of grooves disposed on the outer surface, and an index sleeve movingly disposed on the outer surface, the index sleeve configured to engage the plurality of grooves. The index is incrementable with respect to the plurality of grooves from the distal end toward the proximate end.

Abstract: A particle delivery assembly of an agricultural row unit includes a particle tube configured to receive a particle and to deliver the particle toward a trench in soil. The particle tube includes a first body portion, a second body portion, and a hinge coupled to the first body portion and to the second body portion. The hinge is configured to enable the first body portion and the second body portion to pivot relative to one another between an open position of the particle tube and a closed position of the particle tube.

Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.

Abstract: A fastener includes a shank having a threaded section with a first diameter and an unthreaded section with a second, smaller diameter. A flange is attached to the unthreaded section of the shank. A bushing has a tip, a base, and a tapered sidewall extending from the base to the tip. The bushing defines a central hole received on the unthreaded section with the base adjacent to the flange.

Abstract: Various embodiments disclosed relate to a method for bending a glass substrate. The method includes actuating at least one heat shield to a first position at least partially covering an edge portion of a first major surface of the glass substrate. The method further includes heating the glass substrate. The method further includes actuating the at least one heat shield to a second position at least partially uncovering the edge portion of the glass substrate.

Abstract: A method for operating an appliance, the appliance including a user interface and a wireless connection module. The method includes establishing a wireless connection between the appliance and a wireless network via the wireless connection module, determining that the appliance is communicating with a remote server via the wireless connection module in response to establishing the wireless connection, and disabling a disconnect button on the user interface for disconnecting the appliance from the wireless connection in response to determining the communication between the appliance and the remote server.

Abstract: A downhole system for multistage fracturing having a first cluster of valves, and a second cluster of valves downhole from the first cluster. Each of the first and second cluster of valves has a frac valve. At least one of the first and the second cluster of valves has a flex valve. A single plugging device is used to open all of the valves in the second cluster, but leaves all valves in the first cluster closed.

Abstract: An appliance includes a wireless communication module in wireless communication with a remote server through an external network and a controller operably coupled to the wireless communication module. A method of ensuring that the appliance is using the latest operating software includes detecting a software verification trigger (such as the replacement or maintenance of a control board), obtaining a current software version and a latest software version, determining that the current and latest software versions do not match, and initiating a software update process to update the controller to the latest software version.

Abstract: Methods, apparatus, systems, and articles of manufacture to extend brake life cycle are disclosed herein. An example vehicle includes a first brake associated with a first wheel of the vehicle, a second brake associated with a second wheel of the vehicle, memory, and a brake controller to execute instructions to detect a first parking event, determine, via a first sensor, a condition of the vehicle, access, from the memory, a record of a second parking event including an activation of the first brake, the second parking event preceding the first parking event, and in response to determining the condition satisfies a threshold, engage the second brake without engaging the first brake.