Abstract: The present disclosure relates to utilizing a hierarchical network communication system to efficiently manage and monitor a controlled hierarchical network. In particular, the hierarchical network communication system utilizes gateway services embedded among various architecture levels of a controlled hierarchical network to facilitate secure communications between levels of the hierarchical network as well as with an authorized external computing device or computing system. In various instances, the gateway service includes various components and elements that facilitate inter-network level communication as well as remote management, including monitoring, configuring, and upgrading components and resources at each level of the controlled hierarchical network.

Abstract: A system includes a stowable cupholder apparatus. The stowable cupholder apparatus includes a cupholder member defined by: a top planar member, the top planar member having a cup hole configured to accommodate a cup; a rear planar member extending from the top planar member; and a base planar member extending from the rear planar member, wherein a gap exists between the top planar member and the base planar member. The stowable cupholder apparatus may include a cup grip ring member attached to the top planar member, the cup grip ring member including a ring and cup grip fingers extending inwardly away from the ring. The stowable cupholder apparatus may include a hinge attached to the rear planar member and configured to attach to a structure, wherein the hinge has a range of motion configured to move the cupholder member between a stowed position and a deployed position.

Abstract: Actinic radiation-curable compositions containing polythiols and urethane/urea-containing polyalkenyl prepolymers that can be used for aerospace coatings and sealants. The coatings can be applied to surfaces and rapidly cured.

Abstract: A system for applying metadata tags based on metadata tag groups is described. The system includes a plurality of compute nodes configured to provide a plurality of computing resources for clients of a provider network and a resource tag manager for the provider network. The resource tag manager is configured to receive, from a first client of an account of the provider network, a creation request to establish a resource attribute group comprising a plurality of resource keys and a plurality of resource values, wherein respective metadata keys correspond to respective resource values. The resource tag manager may receive, from a second client of the account, an application request to apply the resource attribute group to a computing resource and apply the plurality of resource keys and the plurality of resource values to metadata maintained for the computing resource.

Abstract: A system for applying metadata tags based on metadata tag groups is described. The system includes a plurality of compute nodes configured to provide a plurality of computing resources for clients of a provider network and a resource tag manager for the provider network. The resource tag manager is configured to receive, from a first client of an account of the provider network, a creation request to establish a resource attribute group comprising a plurality of resource keys and a plurality of resource values, wherein respective metadata keys correspond to respective resource values. The resource tag manager may receive, from a second client of the account, an application request to apply the resource attribute group to a computing resource and apply the plurality of resource keys and the plurality of resource values to metadata maintained for the computing resource.

Abstract: Disclosed herein are systems and methods for implementing virtualized Road-Side Units (vRSUs). Edge computing devices implementing one or more vRSU services may associate vehicles with identifiers that are based at least in part upon the locations of the vehicles. The locations may be established by location services of the edge computing devices, based upon communication received from the vehicles via wireless cellular communication links. The edge computing devices may then process infrastructure information that they receive, for distribution to the vehicles, at the vRSU services. Based upon the processing of infrastructure information at the vRSU services, messages may be generated for transmission to the vehicles (e.g., over the wireless cellular communication links), with the messages carrying information based upon the infrastructure information, such as in the form of safety messages and/or information messages.

Abstract: Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.

Abstract: Disclosed herein are reagents, compositions and methods for isolating and detecting rare cells such as circulating multiple myeloma cells as well as method of evaluating and treating patients suspected of having diseases of abnormal plasma cells, such as multiple myeloma.

Abstract: A computer-implemented method, system and computer program product for identifying and providing alternative equipment. A digital representation of an equipment used for a user-designated purpose from a digital twin library is identified and selected by a user as corresponding to equipment requiring an alternative. Physical and functional properties of the equipment are then identified from a record of the identified digital representation in the digital twin library. Furthermore, other digital representations of corresponding candidates from the digital twin library are identified to provide an alternative to the equipment based on the user-designated purpose. A three-dimensional printing of one or more of these candidates, including modifications to the physical and/or functional properties of the candidates to function similar to the equipment that needs an alternative, is then performed and provided to the user as alternatives to the equipment.

Abstract: Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.

Abstract: Polythioether prepolymers that have a low nucleation temperature. The symmetry of the polythioether prepolymers is modified by including pendent groups extending from the backbone of the polythioether prepolymer chain and/or the symmetry is modified by including segments having a different number of —C(R)2— groups between heteroatoms. The polythioether prepolymers are stable at low temperature storage conditions for an extended period of time. Compositions prepared using the low nucleation temperature polythioether prepolymers are useful as sealants.

Abstract: Methods, computer program products, and/or systems are provided that perform the following operations: obtaining initial design data associated with a building; obtaining geolocation data associated with the building; obtaining environmental data associated with a location based on the geolocation data; simulating the building in an environment using one or more digital replica models, wherein the simulating of the building is based, at least in part, on the initial design data, the geolocation data, and the environmental data; and generating estimates for power generation capability associated with the building based in part on the simulation of the building in the environment.

Abstract: A nozzle for uniform plasma processing comprises an inlet portion and an outlet portion. The inlet portion has a side surface substantially parallel to a vertical axis. The inlet portion comprises a plurality of gas channels. The outlet portion is coupled to the inlet portion. The outlet portion comprises a plurality of outlets. At least one of the outlets is at an angle other than a right angle relative to the vertical axis.

Abstract: Polythioether prepolymers that have a low nucleation temperature are disclosed. The polythioether prepolymers are stable at low temperature storage conditions for an extended period of time. Compositions prepared using the low nucleation temperature polythioether prepolymers are useful as sealants.

Abstract: A conference management application for a remote conferencing system stores information on a plurality of users and a plurality of client devices though which the plurality of users communicate with the remote conferencing system. The conference management application transmits information for a remote conference to a user, wherein the information that is transmitted is generated by a cognitive engine via learning mechanisms that iteratively incorporate information on previously completed remote conferences, information on the user, and information on the client device used by the user to communicate with the conference management application.

Abstract: Dual cure compositions include a combination of an organoborane complex and a radical oxidizing agent as co-catalysts. The compositions are curable under dark conditions and can be used to catalyze thiol-ene reactions. The compositions are useful as sealants.

Abstract: Actinic radiation-curable compositions containing polythiols and urethane/urea-containing polyalkenyl prepolymers that can be used for aerospace coatings and sealants. The coatings can be applied to surfaces and rapidly cured.

Abstract: Actinic radiation-curable compositions containing polythiols and urethane/urea-containing polyalkenyl prepolymers that can be used for aerospace coatings and sealants. The coatings can be applied to surfaces and rapidly cured.

Abstract: Disclosed are methods for making a cured sealant. The methods include depositing an uncured sealant composition on a substrate and exposing the uncured sealant composition to actinic radiation to provide a cured sealant. The uncured sealant composition includes a thiol-terminated polythioether, a polyene comprising a polyvinyl ether and/or a polyallyl compound, and a hydroxy-functional vinyl ether. Related sealant compositions are also disclosed.

Abstract: Provided herein are isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a FN3 domain specifically binds human prostate specific membrane antigen (PSMA) and a second antigen-binding site immunospecifically binds CD3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins. In addition, methods of using the provided isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof are described.