Abstract: Provided is a GII.4 norovirus virus-like particle or active fragment thereof, and use thereof, the virus-like particle comprising or being composed of an amino acid sequence shown as SEQ ID NO: 4. Further, provided is a composition or a kit comprising the GII.4 norovirus virus-like particle, and use thereof. The objective of covering multiple genotypes is achieved by using a single antigen of the invention, the process difficulty of the preparation for a pharmaceutical composition or a vaccine can be reduced, and the production cost is decreased. Also, provided is a norovirus immune composition or a kit comprising GII.2, GII.4, GII.6, and GII.17 norovirus virus-like particles or active fragments thereof, and use thereof.

Abstract: An online concierge system maintains historical orders received from a user that include one or more items. For items included in one more historical orders, the online concierge system determines an interval between orders including an item, providing an indication of a frequency with which the user orders the item. When the online concierge system receives a request to create an order from the user, in response to an amount of time between a most recently received order including the item and a time when the request was received is within a threshold duration of the interval between orders including the item, the online concierge system selects an item from a category including the item. The selected item may be the item or an alternative item in the category. Subsequently, the online concierge system displays an interface for the user that is prepopulated with information identifying the selected item.

Abstract: An online concierge system maintains historical orders received from a user that include one or more items. For items included in one more historical orders, the online concierge system determines an interval between orders including an item, providing an indication of a frequency with which the user orders the item. When the online concierge system receives a request to create an order from the user, in response to an amount of time between a most recently received order including the item and a time when the request was received is within a threshold duration of the interval between orders including the item, the online concierge system selects an item from a category including the item. The selected item may be the item or an alternative item in the category. Subsequently, the online concierge system displays an interface for the user that is prepopulated with information identifying the selected item.

Abstract: An online system may receive, from a content provider, a content presentation campaign that includes one or more objectives. The online system may define a set of one or more policy functions that automatically controls the content presentation campaign. A policy function may control one or more criteria in bidding content slots. The online system may monitor a realized outcome of the content presentation campaign. The online system may apply a reinforcement learning algorithm in adjusting the set of policy functions. The reinforcement learning algorithm adjusts one or more parameters in the set of policy functions to reduce a difference between the realized outcome and the desired outcome set by the content provider. The online system generates an adjusted set of policy functions and uses the adjusted set of policy functions in bidding content slots to present one or more content items provided by the content provider.

Abstract: A method of manufacturing an electric connector includes: providing a metal strip and stamping on the metal strip at a stamping station to obtain a terminal set; packaging and conveying the terminal set to an electroplating station; electroplating and conveying the terminal set to an assembling station; bending and assembling the terminal set into the insulator. The bending operation of the terminal set is transferred to be carried out on the assembling station after the electroplating operation, and is prevented from being carried out at the stamping station. On the one hand, the structure of the terminal set can be kept flat after stamping, which can improve the packaging efficiency and the packaging quantity. On the other hand, the relatively flat structure of the terminal set is more conducive to electroplating treatment, which can improve the electroplating quality and prevent the terminal from deforming.

Abstract: An online concierge system trains a user interaction model to predict a probability of a user performing an interaction after one or more content items are displayed to the user. This provides a measure of an effect of displaying content items to the user on the user performing one or more interactions. The user interaction model is trained from displaying content items to certain users of the online concierge system and withholding display of the content items to other users of the online concierge system. To train the user interaction model, the user interaction model is applied to labeled examples identifying a user and value based on interactions the user performed after one or more content items were displayed to the user and interactions the user performed when one or more content items were not used.

Abstract: An online concierge system allows a user to provide a nutritional goal and uses the nutritional goal as a constraint for selecting candidate orders to display to the user. From prior orders from the user, the online concierge system generates order templates including combinations of generic item descriptions corresponding to items previously included in orders from the user. From the order templates, the online concierge system generates candidate orders including specific items from a warehouse corresponding to the generic item descriptions. The online concierge system selects a set of the candidate orders that each include specific items with combined nutritional information satisfying the user's nutritional goal. Based on probabilities of the user purchasing different candidate orders of the set, the online concierge system selects one or more candidate orders of the set for display to the user.

Abstract: An online concierge system trains a user interaction model to predict a probability of a user performing an interaction after one or more content items are displayed to the user. This provides a measure of an effect of displaying content items to the user on the user performing one or more interactions. The user interaction model is trained from displaying content items to certain users of the online concierge system and withholding display of the content items to other users of the online concierge system. To train the user interaction model, the user interaction model is applied to labeled examples identifying a user and value based on interactions the user performed after one or more content items were displayed to the user and interactions the user performed when one or more content items were not used.

Abstract: An online concierge system enables users to create lists of items and generate a link allowing other receiving users to access a list by selecting the link. When a receiving user selects the link, the online concierge system generates a user-specific list from the original list. The user-specific list includes user-specific items selected for the receiving user that replace items in the original list based on item availability to the receiving user, receiving user preferences, and other receiving user-specific criteria. The receiving user can then view the user-specific items in the user-specific list via an interface allowing the user-specific items in the user-specific list to be included in an order in a single interaction.

Abstract: An online concierge system trains a user interaction model to predict a probability of a user performing an interaction after one or more content items are displayed to the user. This provides a measure of an effect of displaying content items to the user on the user performing one or more interactions. The user interaction model is trained from displaying content items to certain users of the online concierge system and withholding display of the content items to other users of the online concierge system. To train the user interaction model, the user interaction model is applied to labeled examples identifying a user and value based on interactions the user performed after one or more content items were displayed to the user and interactions the user performed when one or more content items were not used.

Abstract: An online concierge system maintains a taxonomy associating one or more specific items offered by a warehouse with a generic item description. When the online concierge system receives a generic item description from a user for inclusion in an order, the online concierge system uses the taxonomy to select a set of items associated with the generic item description. Based on probabilities of the user purchasing various items of the set, the online concierge system selects an item of the set for inclusion in the order For example, the online concierge system selects an item of the set for which the user has a maximum probability of being purchased. Subsequently, the online concierge system displays an interface for the user that is prepopulated with information identifying the selected item of the set.

Abstract: An online concierge system maintains historical orders received from a user that include one or more items. For items included in one more historical orders, the online concierge system determines an interval between orders including an item, providing an indication of a frequency with which the user orders the item. When the online concierge system receives a request to create an order from the user, in response to an amount of time between a most recently received order including the item and a time when the request was received is within a threshold duration of the interval between orders including the item, the online concierge system selects an item from a category including the item. The selected item may be the item or an alternative item in the category. Subsequently, the online concierge system displays an interface for the user that is prepopulated with information identifying the selected item.

Abstract: A nano-electro-mechanical systems (NEMS) oscillator can include an insulating substrate, a source electrode and a drain electrode, a metal local gate electrode, and a micron-sized, atomically thin graphene resonator. The source electrode and drain electrode can be disposed on the insulating substrate. The metal local gate electrode can be disposed on the insulating substrate. The graphene resonator can be suspended over the metal local gate electrode and define a vacuum gap between the graphene resonator and the metal local gate electrode.

Abstract: This invention comprises a nonlinear micro- and nano-mechanical resonator that can maintain frequency of operation and amplitude of operation for a period of time after all external power has been removed from the device. Utilizing specific nonlinear dynamics of the micromechanical resonator, mechanical energy at low frequencies can be input and stored in higher frequencies modes, thus using the multiple degrees of freedom of the resonator to extend its energy storage capacity. Furthermore, the energy stored in multiple vibrational modes can be used to maintain the resonator oscillating for a fixed period of time, even without an external power supply. This is the first demonstration of an “autonomous” frequency source that can maintain a constant frequency and vibrating amplitude when no external power is provided, making it ideal for applications requiring an oscillator in low power, or limited and intermittent power supplies.

Abstract: A fabricated electromechanical device is disclosed herein. An exemplary device includes, a substrate, at least one layer of a high-transconductance material separated from the substrate by a dielectric medium, a first electrode in electrical contact with the at least one layer of a high-transconductance material and separated from the substrate by at least one first supporting member, a second electrode in electrical contact with the layer of a high-transconductance material and separated from the substrate by at least one second supporting member, where the first electrode is electrically separate from the second electrode, and a third electrode separated from the at least one layer of high-transconductance material by a dielectric medium and separated from each of the first electrode and the second electrode by a dielectric medium.

Abstract: A nano-electro-mechanical systems (NEMS) oscillator can include an insulating substrate, a source electrode and a drain electrode, a metal local gate electrode, and a micron-sized, atomically thin graphene resonator. The source electrode and drain electrode can be disposed on the insulating substrate. The metal local gate electrode can be disposed on the insulating substrate. The graphene resonator can be suspended over the metal local gate electrode and define a vacuum gap between the graphene resonator and the metal local gate electrode.

Abstract: A fabricated electromechanical device is disclosed herein. An exemplary device includes, a substrate, at least one layer of a high-transconductance material separated from the substrate by a dielectric medium, a first electrode in electrical contact with the at least one layer of a high-transconductance material and separated from the substrate by at least one first supporting member, a second electrode in electrical contact with the layer of a high-transconductance material and separated from the substrate by at least one second supporting member, where the first electrode is electrically separate from the second electrode, and a third electrode separated from the at least one layer of high-transconductance material by a dielectric medium and separated from each of the first electrode and the second electrode by a dielectric medium.

Abstract: A fabricated electromechanical device is disclosed herein. An exemplary device includes, a substrate, at least one layer of a high-transconductance material separated from the substrate by a dielectric medium, a first electrode in electrical contact with the at least one layer of a high-transconductance material and separated from the substrate by at least one first supporting member, a second electrode in electrical contact with the layer of a high-transconductance material and separated from the substrate by at least one second supporting member, where the first electrode is electrically separate from the second electrode, and a third electrode separated from the at least one layer of high-transconductance material by a dielectric medium and separated from each of the first electrode and the second electrode by a dielectric medium.

Abstract: A fabricated electromechanical device is disclosed herein. An exemplary device includes, a substrate, at least one layer of a high-transconductance material separated from the substrate by a dielectric medium, a first electrode in electrical contact with the at least one layer of a high-transconductance material and separated from the substrate by at least one first supporting member, a second electrode in electrical contact with the layer of a high-transconductance material and separated from the substrate by at least one second supporting member, where the first electrode is electrically separate from the second electrode, and a third electrode separated from the at least one layer of high-transconductance material by a dielectric medium and separated from each of the first electrode and the second electrode by a dielectric medium.