Patents by Inventor Changjoon Justin Lee
Changjoon Justin Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11053190Abstract: The present disclosure relates to an ?-aminoamide derivative compound and a pharmaceutical composition containing the same. According to various embodiments of the present disclosure, provided is a therapeutic agent which can overcome the disadvantages of existing drugs used as a MAO-B inhibitor and, specifically, reversibly inhibits MAO-B through a non-covalent bond so as to alleviate or eliminate the side effects of the existing drugs which exhibit a therapeutic effect by irreversibly acting via a covalent bond with MAO-B. Particularly, a new compound having superior stability and efficacy compared to the existing reversible MAO-B inhibitors may be provided.Type: GrantFiled: April 24, 2020Date of Patent: July 6, 2021Assignee: NeuroBiogen Co., Ltd.Inventors: Ki Duk Park, ChangJoon Justin Lee, Dong Jin Kim, Ae Nim Pae, Hyun Ah Choo, Sun Joon Min, Yong Koo Kang, Yun Kyung Kim, Hyo Jung Song, Ji Won Choi, Min Ho Nam, Jun Young Heo, Seul Ki Yeon, Bo Ko Jang, Eun Ji Ju, Seon Mi Jo, Jong-Hyun Park
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Patent number: 11021586Abstract: The present disclosure relates to an apparatus and a method for manufacturing a channel-coupled scaffold. The present disclosure provides a method for manufacturing a channel-coupled scaffold, which includes: (1) a step of compressing a first elastic substrate which includes a groove on the surface of the substrate to close the groove; (2) a step of loading a scaffold composition onto the closed groove; and (3) a step of restoring the elastic substrate. The present disclosure also provides an apparatus for manufacturing a channel-coupled scaffold, which includes: a first elastic substrate which includes a groove on the surface of the substrate and onto which a scaffold composition is loaded: and a compression module which compresses the width of the groove of the elastic substrate to close it. The apparatus or method may accumulate a microchannel controlling local mass transfer, and align a collagen fiber in the scaffold at the same time.Type: GrantFiled: February 21, 2017Date of Patent: June 1, 2021Assignee: Korea Institute of Science and TechnologyInventors: Nakwon Choi, Sohyun Kim, Sohyeon Jeong, Eui Sung Yoon, Changjoon Justin Lee, Il-Joo Cho
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Publication number: 20200308104Abstract: The present disclosure relates to an ?-aminoamide derivative compound and a pharmaceutical composition containing the same. According to various embodiments of the present disclosure, provided is a therapeutic agent which can overcome the disadvantages of existing drugs used as a MAO-B inhibitor and, specifically, reversibly inhibits MAO-B through a non-covalent bond so as to alleviate or eliminate the side effects of the existing drugs which exhibit a therapeutic effect by irreversibly acting via a covalent bond with MAO-B. Particularly, a new compound having superior stability and efficacy compared to the existing reversible MAO-B inhibitors may be provided.Type: ApplicationFiled: April 24, 2020Publication date: October 1, 2020Inventors: Ki Duk PARK, ChangJoon Justin LEE, Dong Jin KIM, Ae Nim PAE, Hyun Ah CHOO, Sun Joon MIN, Yong Koo KANG, Yun Kyung KIM, Hyo Jung SONG, Ji Won CHOI, Min Ho NAM, Jun Young HEO, Seul Ki YEON, Bo Ko JANG, Eun Ji JU, Seon Mi JO, Jong-Hyun PARK
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Patent number: 10676425Abstract: The present disclosure relates to an ?-aminoamide derivative compound and a pharmaceutical composition containing the same, for treating a neurodegenerative diseases.Type: GrantFiled: September 24, 2015Date of Patent: June 9, 2020Assignee: MEGABIOWOOD CO., LTDInventors: Ki Duk Park, ChangJoon Justin Lee, Dong Jin Kim, Ae Nim Pae, Hyun Ah Choo, Sun Joon Min, Yong Koo Kang, Yun Kyung Kim, Hyo Jung Song, Ji Won Choi, Min Ho Nam, Jun Young Heo, Seul Ki Yeon, Bo Ko Jang, Eun Ji Ju, Seon Mi Jo, Jong-Hyun Park
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Patent number: 9834537Abstract: Disclosed is a novel compound to function as a calcium-dependent chloride channel blocking agent.Type: GrantFiled: November 27, 2013Date of Patent: December 5, 2017Assignee: Korea Institute of Science and TechnologyInventors: Eun Joo Roh, Changjoon Justin Lee, Soo Jin Oh, Seok Jin Hwang, Jong Hoon Jung
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Patent number: 9803167Abstract: The present disclosure relates to stretching apparatus and method for aligning microfibrils. Specifically, the present disclosure provides an apparatus for aligning microfibrils along a single direction, which includes: a first elastic substrate onto which a composition containing microfibrils is loaded; and a stretching module which stretches the width of the elastic substrate. In accordance with the apparatus the present disclosure, microfibrils or cells may be aligned along a particular direction simply by pulling and then releasing the elastic substrate. The present disclosure is also useful for culturing of the aligned cells because the physiological activity of the cells can be maintained and cytotoxicity can be prevented.Type: GrantFiled: November 24, 2015Date of Patent: October 31, 2017Assignee: Korea Institute of Science and TechnologyInventors: Nakwon Choi, Eun-Mi Hur, Sohyun Kim, Sun-Kyoung Im, Eui Sung Yoon, Changjoon Justin Lee
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Publication number: 20170298011Abstract: The present disclosure relates to an ?-aminoamide derivative compound and a pharmaceutical composition containing the same. According to various embodiments of the present disclosure, provided is a therapeutic agent which can overcome the disadvantages of existing drugs used as a MAO-B inhibitor and, specifically, reversibly inhibits MAO-B through a non-covalent bond so as to alleviate or eliminate the side effects of the existing drugs which exhibit a therapeutic effect by irreversibly acting via a covalent bond with MAO-B. Particularly, a new compound having superior stability and efficacy compared to the existing reversible MAO-B inhibitors may be provided.Type: ApplicationFiled: September 24, 2015Publication date: October 19, 2017Inventors: Ki Duk PARK, ChangJoon Justin LEE, Dong Jin KIM, Ae Nim PAE, Hyun Ah CHOO, Sun Joon MIN, Yong Koo KANG, Yun Kyung KIM, Hyo Jung SONG, Ji Won CHOI, Min Ho NAM, Jun Young HEO, Seul Ki YEON, Bo Ko JANG, Eun Ji JU, Seon Mi JO, Jong-Hyun PARK
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Publication number: 20170253860Abstract: The present disclosure relates to an apparatus and a method for manufacturing a channel-coupled scaffold. The present disclosure provides a method for manufacturing a channel-coupled scaffold, which includes: (1) a step of compressing a first elastic substrate which includes a groove on the surface of the substrate to close the groove; (2) a step of loading a scaffold composition onto the closed groove; and (3) a step of restoring the elastic substrate. The present disclosure also provides an apparatus for manufacturing a channel-coupled scaffold, which includes: a first elastic substrate which includes a groove on the surface of the substrate and onto which a scaffold composition is loaded: and a compression module which compresses the width of the groove of the elastic substrate to close it. The apparatus or method may accumulate a microchannel controlling local mass transfer, and align a collagen fiber in the scaffold at the same time.Type: ApplicationFiled: February 21, 2017Publication date: September 7, 2017Applicant: Korea Institute of Science and TechnologyInventors: Nakwon CHOI, Sohyun KIM, Sohyeon JEONG, Eui Sung YOON, Changjoon Justin LEE, Il-Joo CHO
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Patent number: 9469653Abstract: A pharmaceutical composition for preventing or treating a degenerative brain disease, and a method of screening a material for preventing or treating a degenerative brain disease. The method may effectively screen a prophylactic or therapeutic candidate material for preventing or treating a degenerative brain disease. A variety of degenerative brain diseases may be effectively prevented or treated using the pharmaceutical composition including a screened material for preventing or treating a degenerative brain disease.Type: GrantFiled: January 27, 2014Date of Patent: October 18, 2016Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Changjoon Justin Lee, Seonmi Jo, Boeun Yoon, Hyunah Choo, Ji Yoon Kim, Daesoo Kim
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Patent number: 9458120Abstract: The present invention relates to a novel phenoxypropanol derivative, represented by the structure of Chemical Formula I, and a racemate thereof, a pharmaceutically acceptable salt thereof, a solvate thereof and a hydrate thereof, wherein * represents an (R)-form or an (S)-form, X is selected from the group consisting of hydrogen, halogen and substituted or unsubstituted straight or branched alkyl having 1 to 4 carbon atoms, and n represents the number of X and an integer of 1 to 5, wherein at least a hydrogen is substituted with halogen in the substituted linear or branched alkyl having 1 to 4 carbon atoms. The derivative can be used for blocking T-type calcium channel and/or TREK channel, and for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.Type: GrantFiled: November 30, 2012Date of Patent: October 4, 2016Assignee: KORBA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Eun-Joo Roh, Kye-Jung Shin, Changjoon Justin Lee, Soo Jin Oh, Jung-Eun Park, Jeong Eun Yang, Eun Mi Hwang, Dong Ho Woo, Soon-Hyouk Lee, Dong-Gyu Kim, Hee-jung Chun, Wan-Keun Ji, Yun-Soo Na
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Publication number: 20160152946Abstract: The present disclosure relates to stretching apparatus and method for aligning microfibrils. Specifically, the present disclosure provides an apparatus for aligning microfibrils along a single direction, which includes: a first elastic substrate onto which a composition containing microfibrils is loaded; and a stretching module which stretches the width of the elastic substrate. In accordance with the apparatus the present disclosure, microfibrils or cells may be aligned along a particular direction simply by pulling and then releasing the elastic substrate. The present disclosure is also useful for culturing of the aligned cells because the physiological activity of the cells can be maintained and cytotoxicity can be prevented.Type: ApplicationFiled: November 24, 2015Publication date: June 2, 2016Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Nakwon CHOI, Eun-Mi HUR, Sohyun KIM, Sun-Kyoung IM, Eui Sung YOON, Changjoon Justin LEE
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Patent number: 9095535Abstract: A GABA (gamma-aminobutyric acid) release-inhibiting agent in the cerebellum and a composition for treating pathological symptoms caused by over-release of GABA in the cerebellum, each comprising a Bestrophin 1 (Best1) channel inhibitor as an active ingredient; a GABA release-promoting agent in the cerebellum and a composition for treating pathological symptoms caused by the deficit of GABA in the cerebellum, each comprising a Best1 channel activator as an active ingredient; and a method for screening a GABA release-regulating agent in the cerebellum, which uses Best1 channel as target, are provided.Type: GrantFiled: August 24, 2010Date of Patent: August 4, 2015Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Changjoon Justin Lee, Soo-Jung Lee, Bo-Eun Yoon
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Publication number: 20150166496Abstract: The present invention relates to a novel phenoxypropanol derivative, use thereof for blocking T-type calcium channel and/or TREK channel, and use thereof for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.Type: ApplicationFiled: November 30, 2012Publication date: June 18, 2015Inventors: Eun-Joo Roh, Kye-Jung Shin, Changjoon Justin Lee, Soo Jin Oh, Jung-Eun Park, Jeong Eun Yang, Eun Mi Hwang, Dong Ho Woo, Soon-Hyouk Lee, Dong-Gyu Kim, Hee-jung Chun, Wan-Keun Ji, Yun-Soo Na
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Publication number: 20150148550Abstract: Disclosed is a novel compound to function as a calcium-dependent chloride channel blocking agent.Type: ApplicationFiled: November 27, 2013Publication date: May 28, 2015Applicant: Korea Institute of Science and TechnologyInventors: Eun Joo ROH, Changjoon Justin LEE, Soo Jin OH, Jong Hoon JUNG
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Patent number: 8871463Abstract: The present invention investigate the two modes of glutamate release and the releasing rate of glutamate, and thus can provide a useful technique for neuron protection and acceleration of neurotransmission by controlling the glutamate release in astroctye. Thus, the present invention provides an inhibitor of the fast-mode release and/or the slow-mode release of astrocytic glutamate, a screening method of the inhibitor and a pharmaceutical composition or method of ameliorating, preventing and/or treating the disease associated with the over-release of glutamate via the Ca2+-activated anion channel, with the inhibition of fast-mode glutamate release.Type: GrantFiled: July 23, 2013Date of Patent: October 28, 2014Assignee: Korea Institute of Science and TechnologyInventors: Changjoon Justin Lee, Soo Jin Oh, Eun Mi Hwang, Dong Ho Woo
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Publication number: 20140142089Abstract: A pharmaceutical composition for preventing or treating a degenerative brain disease, and a method of screening a material for preventing or treating a degenerative brain disease. The method may effectively screen a prophylactic or therapeutic candidate material for preventing or treating a degenerative brain disease. A variety of degenerative brain diseases may be effectively prevented or treated using the pharmaceutical composition including a screened material for preventing or treating a degenerative brain disease.Type: ApplicationFiled: January 27, 2014Publication date: May 22, 2014Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Changjoon Justin LEE, SEONMI JO, BOEUN YOON, HYUNAH CHOO, JI YOON KIM, DAESOO KIM
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Publication number: 20140093490Abstract: The present invention investigate the two modes of glutamate release and the releasing rate of glutamate, and thus can provide a useful technique for neuron protection and acceleration of neurotransmission by controlling the glutamate release in astroctye. Thus, the present invention provides an inhibitor of the fast-mode release and/or the slow-mode release of astrocytic glutamate, a screening method of the inhibitor and a pharmaceutical composition or method of ameliorating, preventing and/or treating the disease associated with the over-release of glutamate via the Ca2+-activated anion channel, with the inhibition of fast-mode glutamate release.Type: ApplicationFiled: July 23, 2013Publication date: April 3, 2014Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Changjoon Justin LEE, Soo Jin OH, Eun Mi HWANG, Dong Ho WOO
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Publication number: 20130046093Abstract: A pharmaceutical composition for preventing or treating a degenerative brain disease, and a method of screening a material for preventing or treating a degenerative brain disease. The method may effectively screen a prophylactic or therapeutic candidate material for preventing or treating a degenerative brain disease. A variety of degenerative brain diseases may be effectively prevented or treated using the pharmaceutical composition including a screened material for preventing or treating a degenerative brain disease.Type: ApplicationFiled: August 17, 2012Publication date: February 21, 2013Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Changjoon Justin LEE, Seonmi Jo, Boeun Yoon, Hyunah Choo, Ji Yoon Kim, Daesoo Kim
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Publication number: 20120214742Abstract: A GABA (gamma-aminobutyric acid) release-inhibiting agent in the cerebellum and a composition for treating pathological symptoms caused by over-release of GABA in the cerebellum, each comprising a Bestrophin 1(Best1) channel inhibitor as an active ingredient; a GABA release-promoting agent in the cerebellum and a composition for treating pathological symptoms caused by the deficit of GABA in the cerebellum, each comprising a Best1 channel activator as an active ingredient; and a method for screening a GABA release-regulating agent in the cerebellum, which uses Best1 channel as target, are provided.Type: ApplicationFiled: August 24, 2010Publication date: August 23, 2012Inventors: Changjoon Justin Lee, Soo-Jung Lee, Bo-Eun Yoon
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Patent number: 7842471Abstract: The present invention relates to a novel use of a transfected cell as a biosensor, wherein the transfected cell expresses a receptor specific to a bio-signal transmitter, and a highly sensitive detector and a highly sensitive detecting method of a bio-signal transmitter using the biosensor. The bio-signal transmitter detecting technique according to the present invention has an advantage of being applied to a sniffer-patch method, and is capable of providing millisecond time resolution for detecting nanomolar levels of the bio-signal transmitter to be detected.Type: GrantFiled: January 30, 2008Date of Patent: November 30, 2010Assignee: Korea Institute of Science and TechnologyInventors: Changjoon Justin Lee, Dong-Ho Woo