Patents by Inventor Changlin Fu

Changlin Fu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210108217
    Abstract: The current invention provides a modular vector system that enables the insertion of gene expression cassettes in a recursive directional stacking fashion by rare restriction sites which requires only one type of vector. The invention also provides DNA molecules, compositions, and transgenic organisms, plants, plant tissues, plant seeds, and cells comprising recombined restriction sites for rare restriction enzymes.
    Type: Application
    Filed: August 20, 2020
    Publication date: April 15, 2021
    Inventors: Changlin Fu, Jinyuan Liu
  • Patent number: 10829772
    Abstract: The current invention provides a modular vector system that enables the insertion of gene expression cassettes in a recursive directional stacking fashion by rare restriction sites which requires only one type of vector. The invention also provides DNA molecules, compositions, and transgenic organisms, plants, plant tissues, plant seeds, and cells comprising recombined restriction sites for rare restriction enzymes.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: November 10, 2020
    Assignee: MONSANTO TECHNOLOGY LLC
    Inventors: Changlin Fu, Jinyuan Liu
  • Publication number: 20160264980
    Abstract: This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency; enhanced cold tolerance, increased yield, enhanced-nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
    Type: Application
    Filed: January 29, 2016
    Publication date: September 15, 2016
    Inventors: Mark Scott Abad, Thomas R. Adams, Ameeta K. Agarwa, James A. Ball, Paolo Castiglioni, Banu Gopalan, Erin Bell, Shobha Char, Robert J. Bensen, Raghava S. Boddupalli, Alessandra Frizzi, Jill Deikman, Robert L. D'Ordine, Michael D. Edgerton, Xianfeng Chen, Mary Fernandes, Paul S. Chomet, Stephen Duff, Deborah G. Rucker, Changlin Fu, Jeffery E. Ahrens, Stanton B. Dotson, Richard E. Finger, Jinzhuo Dong, Molian Deng
  • Publication number: 20150177244
    Abstract: Methods and compositions are provided for making a necrotizing enterocolitis (NEC) or sepsis assessment of an individual. Aspects of the methods include detecting a biomarker or panel of biomarkers selected from MMP7, EpCAM, and CRP. In addition, reagents, devices, systems and kits thereof that find use in practicing the subject methods are provided.
    Type: Application
    Filed: December 19, 2014
    Publication date: June 25, 2015
    Inventors: Bruce Xuefeng Ling, Karl G. Sylvester, Changlin Fu, Shan Xiang Wang, Dokyoon Kim
  • Publication number: 20150152428
    Abstract: The current invention provides a modular vector system that enables the insertion of gene expression cassettes in a recursive directional stacking fashion by rare restriction sites which requires only one type of vector. The invention also provides DNA molecules, compositions, and transgenic organisms, plants, plant tissues, plant seeds, and cells comprising recombined restriction sites for rare restriction enzymes.
    Type: Application
    Filed: June 10, 2013
    Publication date: June 4, 2015
    Applicant: MONSANTO TECHNOLOGY LLC
    Inventors: Changlin Fu, Jinyuan Liu
  • Patent number: 8609614
    Abstract: Methods are provided for preventing or attenuating pathoangiogenic conditions by administering at least one GBS toxin receptor polypeptide or at least one immunogenic fragment thereof. Also provided are a composition that includes a GBS toxin receptor polypeptide and a method for making such a composition. In another embodiment of the invention, immunized animals also receive GBS toxin, immunocompatible antibodies to the GBS toxin receptor, and/or expanded autologous T cells to the GBS toxin receptor. Also included in this invention are methods of identifying additional GBS toxin receptors.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: December 17, 2013
    Assignee: Vanderbilt University
    Inventors: Carl G. Hellerqvist, Changlin Fu
  • Patent number: 8324482
    Abstract: Disclosed herein are transgenic plants having recombinant DNA which expresses a G1073 transcription factor which provides enhanced resistance and/or tolerance to water deficit. More specifically the DNA constructs comprise a polynucleotide which encodes at least a functional part of a G1073 transcription factor or a homologous transcription factor.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: December 4, 2012
    Assignee: Monsanto Technology LLC
    Inventors: Jindong Sun, Kimberly Zobrist, Jingrui Wu, Changlin Fu, Stanton B. Dotson, Linda Lutfiyya
  • Publication number: 20120227131
    Abstract: This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
    Type: Application
    Filed: September 8, 2011
    Publication date: September 6, 2012
    Inventors: Mark S. Abad, Thomas R. Adams, Ameeta K. Argarwal, James A. Ball, Paolo Castiglioni, Banu Gopalan, Erin Bell, Shobha Char, Robert J. Bensen, Raghava S. Boddupalli, Alessandra Frizzi, Jill Deikman, Robert D'Ordine, Michael D. Edgerton, Xianfeng Chen, Mary Fernandes, Paul S. Chomet, Stephen Duff, Deborah G. Rucker, Changlin Fu, Jeffrey E. Ahrens, Stanton B. Dotson, Richard E. Finger, Jinzhuo Dong, Molian Deng
  • Publication number: 20110217316
    Abstract: Methods are provided for preventing or attenuating pathoangiogenic conditions by administering at least one GBS toxin receptor polypeptide or at least one immunogenic fragment thereof. Also provided are a composition that includes a GBS toxin receptor polypeptide and a method for making such a composition. In another embodiment of the invention, immunized animals also receive GBS toxin, immunocompatible antibodies to the GBS toxin receptor, and/or expanded autologous T cells to the GBS toxin receptor. Also included in this invention are methods of identifying additional GBS toxin receptors.
    Type: Application
    Filed: February 7, 2011
    Publication date: September 8, 2011
    Applicant: Vanderbilt University
    Inventors: Carl G. Hellerqvist, Changlin Fu
  • Publication number: 20110099655
    Abstract: Disclosed herein are transgenic plants having recombinant DNA which expresses a G1073 transcription factor which provides enhanced resistance and/or tolerance to water deficit. More specifically the DNA constructs comprise a polynucleotide which encodes at least a functional part of a G1073 transcription factor or a homologous transcription factor.
    Type: Application
    Filed: December 20, 2010
    Publication date: April 28, 2011
    Applicant: MONSANTO TECHNOLOGY, LLC
    Inventors: Jindong Sun, Kimberly Zobrist, Jingrui Wu, Changlin Fu, Stanton B. Dotson, Linda Lutfiyya
  • Patent number: 7897843
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties, including increased biomass or improved cold or other osmotic stress tolerance, as compared to wild-type or reference plants. The invention also pertains to expression systems that may be used to regulate these transcription factor polynucleotides, providing constitutive, transient, inducible and tissue-specific regulation.
    Type: Grant
    Filed: June 16, 2004
    Date of Patent: March 1, 2011
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Cai-Zhong Jiang, Jacqueline E. Heard, Oliver Ratcliffe, Neal I. Gutterson, Frederick D. Hempel, Roderick W. Kumimoto, James S. Keddie, Bradley K. Sherman, Jeffrey M. Libby, Jindong Sun, Kimberly Faye Zobrist-Duff, Jingrui Wu, Changlin Fu, Stanton B. Dotson, Linda L. Lutfiyya
  • Patent number: 7888557
    Abstract: Disclosed herein are transgenic plants having recombinant DNA which expresses a G1073 transcription factor which provides enhanced resistance and/or tolerance to water deficit. More specifically the DNA constructs comprise a polynucleotide which encodes at least a functional part of a G1073 transcription factor or a homologous transcription factor.
    Type: Grant
    Filed: February 21, 2004
    Date of Patent: February 15, 2011
    Assignee: Monsanto Technology LLC
    Inventors: Jindong Sun, Kimberly Zobrist, Jingrui Wu, Changlin Fu, Stanton B. Dotson, Linda Lutfiyya
  • Patent number: 7754944
    Abstract: Synthetic modular polynucleotide constructs are useful for gene expression in plants, methods for making and using such constructs, and plants transformed with such constructs. The constructs comprise unique restriction sites for each modular element and may further comprise polynucleotide identifier sequences.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: July 13, 2010
    Assignee: Monsanto Technology LLC
    Inventors: Changlin Fu, Brian Hauge, Vicky Gavrias
  • Publication number: 20100076184
    Abstract: A novel GBS toxin receptor, and methods for its preparation and use are provided. GBS toxin receptor polynucleotides and polypeptides are provided as well as detection, screening, and therapeutic methods and pharmaceutical compositions involving such polynucleotides and polypeptides.
    Type: Application
    Filed: June 19, 2008
    Publication date: March 25, 2010
    Applicant: Vanderbilt University
    Inventors: Carl G. Hellerqvist, Changlin Fu
  • Publication number: 20090221804
    Abstract: Methods are provided for preventing or attenuating pathoangiogenic conditions by administering at least one GBS toxin receptor polypeptide or at least one immunogenic fragment thereof. Also provided are a composition that includes a GBS toxin receptor polypeptide and a method for making such a composition. In another embodiment of the invention, immunized animals also receive GBS toxin, immunocompatible antibodies to the GBS toxin receptor, and/or expanded autologous T cells to the GBS toxin receptor. Also included in this invention are methods of identifying additional GBS toxin receptors.
    Type: Application
    Filed: December 9, 2008
    Publication date: September 3, 2009
    Applicant: Vanderbilt University
    Inventors: Carl G. Hellerqvist, Changlin Fu
  • Patent number: 7410640
    Abstract: A novel GBS toxin receptor and methods for its preparation and use are provided. GBS toxin receptor polynucleotides and polypeptides and antibodies to GBS toxin receptor are provided, as well as detection, screening, and therapeutic methods and pharmaceutical compositions involving such polynucleotides, polypeptides and antibodies.
    Type: Grant
    Filed: April 12, 2004
    Date of Patent: August 12, 2008
    Assignee: Vanderbilt University
    Inventors: Carl G. Hellerqvist, Changlin Fu
  • Publication number: 20070234442
    Abstract: Synthetic modular polynucleotide constructs are useful for gene expression in plants, methods for making and using such constructs, and plants transformed with such constructs. The constructs comprise unique restriction sites for each modular element and may further comprise polynucleotide identifier sequences.
    Type: Application
    Filed: April 2, 2007
    Publication date: October 4, 2007
    Inventors: Changlin Fu, Brian Hauge, Vicky Gavrias
  • Publication number: 20050097631
    Abstract: Disclosed herein are transgenic plants having recombinant DNA which expresses a G1073 transcription factor which provides enhanced resistance and/or tolerance to water deficit. More specifically the DNA constructs comprise a polynucleotide which encodes a at least a functional part of a G1073 transcription factor or a homologous transcription factor.
    Type: Application
    Filed: February 21, 2004
    Publication date: May 5, 2005
    Inventors: Jindong Sun, Kimberly Zobrist, Jingrui Wu, Changlin Fu, Stanton Dotson, Linda Lutfiyya
  • Publication number: 20050002931
    Abstract: A novel GBS toxin receptor, and methods for its preparation and use are provided. GBS toxin receptor polynucleotides and polypeptides are provided as well as detection, screening, and therapeutic methods and pharmaceutical compositions involving such polynucleotides and polypeptides.
    Type: Application
    Filed: April 12, 2004
    Publication date: January 6, 2005
    Inventors: Carl Hellerqvist, Changlin Fu
  • Patent number: 6803448
    Abstract: A novel GBS toxin receptor, and methods for its preparation and use are provided. GBS toxin receptor polynucleotides and polypeptides are provided as well as detection, screening, and therapeutic methods and pharmaceutical compositions involving such polynucleotides and polypeptides.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: October 12, 2004
    Assignee: Vanderbilt University
    Inventors: Carl G. Hellerqvist, Changlin Fu