Abstract: The disclosure provides nanometer sized water clusters comprising or consisting essentially of ultrapure water that encapsulate a solute, wherein the water clusters have a median diameter of between about 2 to about 400 nanometers and uses thereof. Also provided by the disclosure are processes and methods for making nanosized water clusters, including processes and methods for encapsulating hydrated solutes in nanosized water clusters.

Abstract: The disclosure provides nanometer sized water clusters comprising or consisting essentially of ultrapure water that encapsulate a solute, wherein the water clusters have a median diameter of between about 2 to about 400 nanometers and uses thereof. Also provided by the disclosure are processes and methods for making nanosized water clusters, including processes and methods for encapsulating hydrated solutes in nanosized water clusters.

Abstract: Methods and systems directed to monitoring for the presence or progression of amyloid diseases via detection of amyloid fibrils in a sample from an individual are disclosed. An individual, or sample from an individual, is treated with a reagent including a fluorescent protein. The fluorescent protein in the reagent binds to amyloid fibrils present in the sample. Detecting a signal from fluorescent protein bound to the treated sample indicates the presence of amyloid fibrils in the sample and possible diagnosis of an amyloid disease. The presence and progression of an amyloid disease is monitored by quantifying signal intensity from samples taken over time. Treatment with a reagent including a fluorescent protein inhibits amyloid fibril formation by providing the reagent to an environment including amyloid monomers. The fluorescent protein binds to amyloid oligomers during the lag phase and/or elongation phase of amyloid fibril formation, preventing formation of mature amyloid fibrils.

Abstract: The invention relates to products by processes, product compositions, product formulations and product uses that are all related to reduced ultrapure water cluster sizes in an aqueous composition containing a non-H2O substance in the reduced size water clusters in order to improve bioavailability of the aqueous composition. The invention processes use higher flow rate of the blended aqueous composition from a jet openings of a nozzle inside the hollow cylinder to reduce sizes of the ultrapure water clusters in the blended aqueous composition of the non-H2O substance to less than 300 nanometers.

Abstract: The invention relates to products by processes, product compositions, product formulations and product uses that are all related to reduced ultrapure water cluster sizes in an aqueous composition containing a non-H2O substance in the reduced size water clusters in order to improve bioavailability of the aqueous composition. The invention processes use higher flow rate of the blended aqueous composition from a jet openings of a nozzle inside the hollow cylinder to reduce sizes of the ultrapure water clusters in the blended aqueous composition of the non-H2O substance to less than 300 nanometers.

Abstract: The invention relates to products by processes, product compositions, product formulations and product uses that are all related to reduced ultrapure water cluster sizes in an aqueous composition containing a non-H2O substance in the reduced size water clusters in order to improve bioavailability of the aqueous composition. The invention processes use higher flow rate of the blended aqueous composition from a jet openings of a nozzle inside the hollow cylinder to reduce sizes of the ultrapure water clusters in the blended aqueous composition of the non-H2O substance to less than 300 nanometers.

Abstract: The invention relates to products by processes, product compositions, product formulations and product uses that are all related to reduced ultrapure water cluster sizes in an aqueous composition containing a non-H2O substance in the reduced size water clusters in order to improve bioavailability of the aqueous composition. The invention processes use higher flow rate of the blended aqueous composition from a jet openings of a nozzle inside the hollow cylinder to reduce sizes of the ultrapure water clusters in the blended aqueous composition of the non-H2O substance to less than 300 nanometers.

Abstract: Methods and systems directed to monitoring for the presence or progression of amyloid diseases via detection of amyloid fibrils in a sample from an individual are disclosed. An individual, or sample from an individual, is treated with a reagent including a fluorescent protein. The fluorescent protein in the reagent binds to amyloid fibrils present in the sample. Detecting a signal from fluorescent protein bound to the treated sample indicates the presence of amyloid fibrils in the sample and possible diagnosis of an amyloid disease. The presence and progression of an amyloid disease is monitored by quantifying signal intensity from samples taken over time. Treatment with a reagent including a fluorescent protein inhibits amyloid fibril formation by providing the reagent to an environment including amyloid monomers. The fluorescent protein binds to amyloid oligomers during the lag phase and/or elongation phase of amyloid fibril formation, preventing formation of mature amyloid fibrils.

Abstract: The disclosure provides nanometer sized water clusters comprising or consisting essentially of ultrapure water that encapsulate a solute, wherein the water clusters have a median diameter of between about 2 to about 400 nanometers and uses thereof. Also provided by the disclosure are processes and methods for making nanosized water clusters, including processes and methods for encapsulating hydrated solutes in nanosized water clusters.

Abstract: Some embodiments of a tally stamp device described herein provide a stamp and a counter system. The tally stamp may include an elongate body housing the stamp and counter system.

Abstract: Some embodiments of a tally stamp device described herein provide a stamp and a counter system. The tally stamp may include an elongate body housing the stamp and counter system.

Abstract: Shaped metal deposition apparatus comprises a mounting head for mounting a shaped metal deposition device, an inert gas shield for providing an inert atmosphere around shaped metal deposited in use by the shaped metal deposition device, and a rotatable coupling between the mounting head and the inert gas shield to permit relative rotation therebetween.

Abstract: A forcing tool is provided in which a lobe aperture incorporates opposed lobe pairs having driving flanks. Distal ends of the driving flanks define a spacing consistent with the width of a dowel or tang to be utilized in a twisted-dowel joint. The aperture incorporates location recesses to allow the dowel or tang to pass through the aperture and then through twisting create a lock condition.

Abstract: The invention provides a fishing apparatus having a pivot arm mounted on a frame with a fishing line paid out on one end of the pivot arm via a flexible fishing rod and a hooking mechanism connected to the opposite end via a trigger line and a pull line. The hooking mechanism may resemble a mouse trap with a trigger connected to the trigger line arm a retaining arm engaging the trigger and retaining a spring-loaded arm in the set position. The spring-loaded arm is connected to the pull line. A fish trying to swim with the hook will cause the pivot arm to tip down, triggering the hooking mechanism. The spring-loaded arm pivots downward rapidly, pulling the pivot arm so that the fishing rod moves upward rapidly and sets the hook in the fish's mouth. The spring bias in the spring-loaded arm then keeps the fishing line under tension so that the fish doesn't release the hook without ripping the hook from the mouth.

Abstract: Embodiments of the present invention include a stationary boat lift in which boats can enter and exit quite readily. The boat lift allows a boat to bypass various barriers in a safe and efficient manner by orienting the boat in a direction substantially parallel to the barrier, vertically lifting the boat out of one waterway, laterally translating the boat horizontally over the barrier, and then vertically lowering the boat into a second waterway.

Abstract: Exemplary bearing cartridges are provided. An outer retaining member defines a first curved surface lined with a lubricant. An inner, carburized titanium member is received by the outer retaining member. The inner member defines a second curved surface in sliding contact with the first curved surface. A carburized case extends a predetermined distance from the second curved surface into the inner member. The bearing cartridge may be installed in a housing. The outer retaining member may include a ring defining a concave spherical surface. The inner member may include a ball defining a convex spherical surface. Alternately, the outer retaining member may include a bushing defining a concave cylindrical surface or a spherical ball defining a bore that defines a concave cylindrical surface and the inner member may include a pin defining a convex cylindrical surface. The lubricant may include a polytetrafluroethylene-based lubricant.

Abstract: A connector is provided for selectively connecting or disconnecting a stripper rubber to or from drilling head equipment such as a bearing assembly. A generally cylindrical adapter connected to the equipment defines a primary bore accommodate a down hole tubular. One or more cam pin bores, adapted to house one or more cam pins, are positioned radially around the adapter substantially parallel to the primary bore. One or more cam lock bores adapted to house one or more at least partially rotatable cam locks, are offset from the pin cam bores such that each cam pin bore partially intersects a corresponding cam lock bore to form an apertaure through which the cam lock engages the cam pin. One or more cam pins are connected to the stripper rubber; and one or more at least partially rotatable cam locks house in the cam lock bores of the adapter optionally engage or disengage the pin cams to respectively connect or disconnect the stripper rubber to or from the equipment.

Abstract: A controlled-release pharmaceutical formulation including cholecalciferol and/or ergocalciferol, a method of making the formulation, and a method of administering the formulation to treat 25-hydroxyvitamin D insufficiency or deficiency, are disclosed. The composition and method of administration preferably result in delayed release of the vitamin(s) in the ileum of the small intestine and sustained, substantially constant, release of the vitamin(s) over an extended period, e.g., at least 4 hours or more. Individual and combined dosages of 500 IU to 50,000 IU per dosage form, preferably daily, are disclosed.

Abstract: The invention provides 24-hydroxyvitamin D compounds and methods for their use in the treatment and prophylaxis of hyperparathyroidism and hyperproliferative diseases, and in the modulation of the immune and inflammatory responses as well as the treatment of bone depletive disorders.

Abstract: The present invention is directed to a conjugate which includes at least one vitamin D moiety thereof and at least one targeting molecule moiety to pharmaceutical compositions of the conjugate, and to methods for using the conjugate for target-specific delivery of vitamin D or analogs thereof to tissues in need thereof. When a particularly preferred form is administered to a patient, the targeting molecule component of the conjugate of this invention seeks out and binds to a tissue of interest, such as bone or tumor tissue, where the vitamin D has a therapeutic effect.