Abstract: We combined single nuclei RNA sequencing with spatial transcriptomics and single-cell resolution spatial proteomic analysis of human bladder cancer to identify an epithelial subpopulation with therapeutic response prediction ability. These cells express Cadherin 12 (CDH12, N-Cadherin 2), catenins, and other epithelial markers. CDH12-enriched tumors define patients with poor outcome following surgery with or without neoadjuvant chemotherapy (NAC), whereas CDH12-enriched tumors have a superior response to immune checkpoint therapy (ICT). Patient stratification by tumor CDH12 enrichment offered better prediction outcome than established bladder cancer subtypes. The CDH12 population resembles an undifferentiated state with chemoresistance. CDH12-enriched cells express PD-L1 and PD-L2 and co-localize with exhausted T-cells, possibly mediated through CD49a (ITGA1), likely explaining ICT efficacy in these tumors.

Abstract: A lifting system for a concrete component comprises a void former incorporated into the component during casting and which provides within the component a void which receives a locking pin of a lifting anchor assembly which is locked within the void by rotation of a locking pin. The lifting anchor assembly has a visual indicator to indicate when the pin is in its locked condition within the void, and a pivotal lifting shackle of the assembly is prevented from movement into a position in which lifting can take place until the pin is in its locked condition. Preferably a base of the void former is configured to retain components of a jacking system by which a concrete slab used for road repair can be jacked into a level configuration with the remainder of the roadway when it has been positioned by use of the lifting system.

Abstract: A lifting system for a concrete component comprises a void former incorporated into the component during casting and which provides within the component a void which receives a locking pin of a lifting anchor assembly which is locked within the void by rotation of a locking pin. The lifting anchor assembly has a visual indicator to indicate when the pin is in its locked condition within the void, and a pivotal lifting shackle of the assembly is prevented from movement into a position in which lifting can take place until the pin is in its locked condition. Preferably a base of the void former is configured to retain components of a jacking system by which a concrete slab used for road repair can be jacked into a level configuration with the remainder of the roadway when it has been positioned by use of the lifting system.

Abstract: A lifting system for a concrete component comprises a void former incorporated into the component during casting and which provides within the component a void which receives a locking pin of a lifting anchor assembly which is locked within the void by rotation of a locking pin. The lifting anchor assembly has a visual indicator to indicate when the pin is in its locked condition within the void, and a pivotal lifting shackle of the assembly is prevented from movement into a position in which lifting can take place until the pin is in its locked condition. Preferably a base of the void former is configured to retain components of a jacking system by which a concrete slab used for road repair can be jacked into a level configuration with the remainder of the roadway when it has been positioned by use of the lifting system.

Abstract: A lifting system for a concrete component comprises a void former incorporated into the component during casting and which provides within the component a void which receives a locking pin of a lifting anchor assembly which is locked within the void by rotation of a locking pin. The lifting anchor assembly has a visual indicator to indicate when the pin is in its locked condition within the void, and a pivotal lifting shackle of the assembly is prevented from movement into a position in which lifting can take place until the pin is in its locked condition. Preferably a base of the void former is configured to retain components of a jacking system by which a concrete slab used for road repair can be jacked into a level configuration with the remainder of the roadway when it has been positioned by use of the lifting system.

Abstract: Biological inspection procedures and surface sanitization procedures are incorporated with a garment providing service to look for and monitor the presence of microbes, such as bacteria in particular, and to eliminate such microbes within the garment service. Biological inspection procedures can be conducted on the garments themselves, or any surface of the garment facility, such as a surface onto which the garments may come into contact after laundering. Preferably, a washing procedure is conducted based upon a cleaning formulation to also minimize the presence of microbes. Garments are preferably inspected after they are laundered and ready for delivery to the customer. Facility surfaces, such as sorting and/or folding tables that may be utilized after laundering, are sanitized and then may be tested in accordance with the present invention to minimize the potential for contamination of garments from such surfaces.

Abstract: Biological inspection procedures and surface sanitization procedures are incorporated with a garment providing service to look for and monitor the presence of microbes, such as bacteria in particular, and to eliminate such microbes within the garment service. Biological inspection procedures can be conducted on the garments themselves, or any surface of the garment facility, such as a surface onto which the garments may come into contact after laundering. Preferably, a washing procedure is conducted based upon a cleaning formulation to also minimize the presence of microbes. Garments are preferably inspected after they are laundered and ready for delivery to the customer. Facility surfaces, such as sorting and/or folding tables that may be utilized after laundering, are sanitized and then may be tested in accordance with the present invention to minimize the potential for contamination of garments from such surfaces.

Abstract: A new and improved coin scoop for slot machines is disclosed, including an open end, a closed end, a handle, and nesting points. The scoop allows the easy removal of coins from the slot machine tray or other currency machine. The scoops are made of a lightweight material and are stackable for easy display and storage.

Abstract: Device and method for removing volatile compounds from a gas stream, the device including a material which is capable of removing and retaining the volatile compounds while displaying a visible color change, wherein at least some moisture has been removed from the material and there is relative movement between the gas stream and the material.