Abstract: A glass fencing system includes glass panels, rails, gaskets, and spigots. The rails extend across the upper edges of the glass panels. The gaskets are fitted within the rails. The spigots support one of the glass panels and comprise a base, a first arm, a first pad, a second arm, and a second pad. The first pad has a first pad surface and a lower surface. The first pad surface is in contact with the first arm and the glass panel. The lower surface extends from the first pad surface and is in contact with the glass panels. The second arm has bores. The second pad has a second pad surface, a backing, a plate, and fasteners. The second pad surface is in contact with the glass panel. The backing is spaced apart from the second pad surface and has backing openings aligned with the bores. The plate is located between the second pad surface and the backing. The fasteners pass through the bores and the backing openings to contact the plate.

Abstract: The present invention relates to novel novel monocyclic and bicyclic ring system substituted carbanucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: A railing system for stairs comprises a plurality of pickets, a first rail, and a second rail. The first rail comprises a handle portion, an attachment portion, and a first cover. The attachment portion is attached to the pickets using fasteners. The first cover is adapted to cover the fasteners when the attachment portion is attached to the pickets. The second rail comprises a base member, a base sidewall, and a second cover. The base member comprises a plurality of base openings adapted to receive the pickets. The base sidewall is attached to the pickets using fasteners. The second cover is adapted to fit over the fasteners when base sidewall is attached to the pickets.

Abstract: The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: Systems and methods for detecting interception devices. In some aspects, the system causes transmission of a first detection signal. Based on receiving a first response signal, the system determines a first probability of detection of a first interception device. Based on the first probability of detection, the system transmits a first command to deactivate a user authentication interface. The system may cause transmission of a second detection signal and determine a second probability of detection of a second interception device. In response to the second probability, the system may transmit a second command to reactivate the user authentication interface.

Abstract: The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (1) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: Embodiments of the present invention relate to 6-6 bicyclic aromatic ring substituted nucleoside analogues, including, for example, the following compound: Embodiments of the present invention also relate to uses of the disclosed compounds for the inhibition of protein arginine methyltransferase 5 (PRMT5).

Abstract: The present invention relates to novel novel monocyclic and bicyclic ring system substituted carbanucleoside analogues of Formula (I), wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The present invention relates to novel novel monocyclic and bicyclic ring system substituted carbanucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The present invention relates novel substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: Embodiments of the present invention relate to 6-6 bicyclic aromatic ring substituted nucleoside analogues, including, for example, the following compound: Embodiments of the present invention also relate to uses of the disclosed compounds for the inhibition of protein arginine methyltransferase 5 (PRMT5).

Abstract: The present invention relates novel substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: Embodiments of the present invention relate to 6-6 bicyclic aromatic ring substituted nucleoside analogues, including, for example, the following compound: Embodiments of the present invention also relate to uses of the disclosed compounds for the inhibition of protein arginine methyltransferase 5 (PRMT5).

Abstract: The present invention relates to novel novel monocyclic and bicyclic ring system substituted carbanucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: A browning control specifically for use with toasters but which can also be used in other applications such as ovens in which the original colour of the item (20) to be browned is ascertained, the required colour for the article (20) is selected by a user and the change of colour of the article is monitored (50, 51, 52) until it reaches the required colour at which time the article (20) is ejected or the power courting the browning is removed.

Abstract: A screw-threaded impeller 50 having a mixing device 55 thereon is provided in a container 10 of a food processor. A drive unit adjacent the bottom of the container is adapted to move the impeller in both a clockwise and a counterclockwise direction. During rotation, food placed within the container is lifted away from the mixing device when the impeller is rotated in one direction and is directed toward the mixing device when the impeller is rotated in the other direction. The mixing device includes a horizontal cutting blade 52 extending perpendicular to the impeller and a scooping blade 51 extending downwardly at an angle from the impeller. In order to lift over obstacles, the mixing device is spring mounted or can move along the helical protrusion toward the upper end of the impeller.

Abstract: A food mixer includes a whipping attachment 60. The attachment includes an elongated impeller 20 that engages a drive of the mixer at the lower surface of a container 10. The attachment also includes a plurality of nested wire-shaped elements 22 attached to a side of the impeller. Because the elements are nested, they travel at a different angular velocities resulting in improved whipping, agitating and mixing characteristics.

Abstract: A food processor having a container and a drive shaft extending through a bottom thereof includes a processing device having an impeller 20 for engaging the drive shaft and a dome-shaped cap or shield 90. The cap includes dimples on a lower surface to assist in breaking up lumps of food in the container. The processing device can rotate in either a clockwise or counterclockwise direction.