Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.

Abstract: A bathtub overflow assembly having an overflow elbow exterior to the bathtub's overflow port with an externally threaded cylinder extending axially from the overflow elbow in the direction of the overflow port. The assembly has an overflow elbow retaining structure in the tub comprising a retainer ring having a flange sized to circumscribe the overflow port on the interior of the tub. The retainer ring has a centrally mounted sleeve which extends axially in the direction of the elbow. The sleeve is internally threaded to cooperatively engage the threads on the overflow elbow cylinder and has a length which is sufficient to enable it to overlap the overflow cylinder. An overflow test plug which threadedly mounts to the retainer ring is also disclosed.

Abstract: A bathtub overflow assembly having an overflow elbow exterior to the bathtub's overflow port with an externally threaded cylinder extending axially from the overflow elbow in the direction of the overflow port. The assembly has an overflow elbow retaining structure in the tub comprising a retainer ring having a flange sized to circumscribe the overflow port on the interior of the tub. The retainer ring has a centrally mounted sleeve which extends axially in the direction of the elbow. The sleeve is internally threaded to cooperatively engage the threads on the overflow elbow cylinder and has a length which is sufficient to enable it to overlap the overflow cylinder. An overflow test plug which threadedly mounts to the retainer ring is also disclosed.

Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through a combination of ex vivo gene therapy protocols and cell enchment, tumor cells are engineered to express an ? (1,3)galactosyl epitope and optionally the tumor associated antigens mesothelin and carcinoembryonic antigen. After administration of the compositions of the invention to patients, the production of increased antibody titers to certain cell-surface markers, including mesothelin, calreticulin, and carcinembryonic antigen (CEA) positively correlates with an increased overall survival.

Abstract: An automatic telephone service forwarding device including a base or enclosure defining a socket for receiving a wireless telephone. Upon detecting the presence of the wireless telephone in the socket, the device automatically forwards telephone service for the wireless telephone to a previously-stored forwarding directory number, typically the directory number of a wireline unit located nearby. Alternatively, the automatic telephone service forwarding device may be incorporated directly into a wireless telephone. In this case, the wireless telephone includes a “forward” button and a scrollable list of forwarding telephone numbers. The automatic telephone service forwarding device may also be configured to automatically select certain forwarding directory numbers from the list in accordance with a predefined time-based profile.

Abstract: A system notifies a computing device of an incoming message. In the system, a message server is coupled to a data communications network for receiving the incoming message, and a communications system is coupled to the message server so that the message server can communicate to the communications system that the incoming message awaits retrieval by the computing device. A communications line is coupled to the communications system and to the computing device so that the communications system can signal the computing device over the communications line that the incoming message awaits retrieval by such computing device. The computing device is for receiving the aforementioned notification and retrieving the incoming message from the message server, and includes a communications device for coupling with the aforementioned communications line.

Abstract: A portable communications device (PCD) is coupled to a first network by way of a second network. The PCD is normally in radio communication with the first network, and is coupled to the first network by way of the second network when the PCD is out of radio communication with the first network. In particular, the PCD is coupled to the second network, and is caused to leave a first network mode and enter a second network mode. A network connection is established with the first network by way of the second network, and communication with the first network is entered into by way of the second network.

Abstract: Methods and apparatus for secure over-the-air (OTA) programming, and particularly, activation, of a wireless unit in a particular communications system. The unit stores a stored key having been generated by using a key algorithm (K-algorithm) with an identifier associated with the unit as an input to the K-algorithm. The unit may receive information such as parameters and a verification number from a communications system for the purpose of programming the unit. The verification number is generated by using an authorization algorithm (A-algorithm) having the parameters and a key as A-algorithm inputs. They key is generated by the K-algorithm having the identifier associated with the K-algorithm input. In response to the receipt of the parameters and the verification number, the wireless unit generates a trial verification number by using the A-algorithm with the parameters and the stored key as trial inputs. The unit compares the verification number to the trial verification number for a match.

Abstract: A wireless telephone backup device for landline telephone equipment that may be located on the customer side of the landline service connection, typically in a restricted access location, such as an attic, basement, or utility closet. An interconnection circuit in the backup device detects service interruptions in the subscriber's landline connection and, in response, powers on a wireless communication device to provide backup telephone service to the customer premises equipment. The interconnection circuit also provides the other features standard landline telephone service, including dial tone, ring voltage, and normal dialing for outgoing calls. The backup device also forwards incoming landline calls to the wireless unit in the backup device, and may send a message notifying a maintenance center of the service interruption. Further, the backup device may initiate an indicator in an alarm system at the site of the customer premises equipment to notify the subscriber of the service interruption.

Abstract: A method of coupling a wireless portable communications device (PCD) to a base station by way of a second network is disclosed. The PCD is normally in communication with the base station by way of a first network, and is coupled to the base station by way of the second network when the PCD is out of communication with the base station by way of the first network. In particular, the PCD is coupled to the second network, and is caused to leave an base station mode and enter a second network mode. A network connection is established with the base station by way of the second network, and communication with the base station is entered into by way of the second network.

Abstract: An automatic telephone service forwarding device including a base or enclosure defining a socket for receiving a wireless telephone. Upon detecting the presence of the wireless telephone in the socket, the device automatically forwards telephone service for the wireless telephone to a previously-stored forwarding directory number, typically the directory number of a wireline unit located nearby. Alternatively, the automatic telephone service forwarding device may be incorporated directly into a wireless telephone. In this case, the wireless telephone includes a “forward” button and a scrollable list of forwarding telephone numbers. The automatic telephone service forwarding device may also be configured to automatically select certain forwarding directory numbers from the list in accordance with a predefined time-based profile.

Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ?(1,3) galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ? galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.

Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an ? (1,3) galactosyl epitope. The cells are then irradiated or otherwise killed and administered to a patient. The ? galactosyl epitope causes opsonization of the tumor cell enhancing uptake of the opsonized tumor cell by antigen presenting cells which results in enhanced tumor specific antigen presentation. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.

Abstract: The invention includes a viral vector method and composition comprising transcomplementary replication incompetent viral vectors, preferably adenoviral vectors, which are cotransformed to a recipient cell. The two vectors complement each other and thus allow viral replication, in a synergistic combination which enhances both gene delivery and gene expression of genetic sequences contained within the vector.

Abstract: One-component adhesives/sealants comprising surface-deactivated solid polyisocyanates and, optionally, isocyanate-reactive, liquid binders can be rapidly cured below the conventional thickening temperature by irradiating with microwaves, for example microwaves of at least 2 wavelengths. This process is particularly suitable for adhesively joining plastic substrates.

Abstract: Systems and methods for providing centralized notification for over the air programming. The centralized notification system includes a central server that generates a message to be delivered to a mobile device. The centralized notification system includes an active server in communication with the central server that receives the message from the central server. The active server communicates with a network element that communicates with the mobile device. The active server queries the network element to determine availability of the mobile device. If the availability of the mobile device is returned from the network device, the message is directly routed to the mobile device, otherwise, the message is routed to a passive server. The passive server monitors message traffic for an event that provides availability information about the mobile device and automatically delivers the message to the mobile device in response thereto.

Abstract: The present invention relates generally to methods and compositions for the identification of differential protein expression patterns and concomitantly the active genetic regions that are directly or indirectly involved in different tissue types, disease states, or other cellular differences desirable for diagnosis or for targets for drug therapy.

Abstract: A method and system for providing targeted advertisement information to consumers over a wireless communications network. In one embodiment, local advertisers register to advertise on certain wireless communications devices that are in close proximity to the advertiser. As a consumer enters a cell site that is near the location of the advertiser, the wireless network delivers a message to the wireless device that is specified by the local advertiser. An acknowledgement signal is then received by the network, and the local advertiser's account is charged for transmission of the advertisement. In a further embodiment, each of the messages stored in the database is also associated with one or more demographic codes, and users of wireless communications device select from one more demographic codes to describer their advertisement preferences.

Abstract: Interactively providing financial advice to an individual via a computer system includes: (a) receiving current information of the advisee, the current information including (i) data indicative of a current financial situation of the advisee including assets of the advisee, and (ii) data indicative of a currently intended future life event of the advisee; (b) determining a future financial obligation of the advisee that is representative of the intended future life event of the advisee; (c) determining a rate of return on investment that is required in order for the advisee to meet the future financial obligation based on the advisee's current financial situation; and (d) providing to the advisee a recommended asset allocation and an indication of the probability that the future financial obligation will be met based on the advisee's current financial situation and the recommended asset allocation. Assistance may be provided through a virtual human advisor.

Abstract: A method for treating tumors. Through infusion or xenotransplantation of xenogeneic cells, such as infusion of murine cells into the peritoneal cavity of humans, a hyperacute rejection response to the cells is induced. This in turn creates a bystander effect to the tumor. This effect creates tumor regression. This treatment can be used alone or in conjunction with gene therapy or chemotherapy treatments.