Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

Abstract: Described herein is an oral appliance. The oral appliance includes upper and lower trays that each include at least one axial spring configured to contact a palatal/lingual surface of at least one tooth, where each axial spring is coupled to the respective upper or lower tray, and where each axial spring is configured to produce and transmit intermittent, cyclic forces to the palatal/lingual surface of the tooth to promote palatal and upper/lower jaw development. The upper and lower trays each include an expansion mechanism to enable adjustment of the size of the upper and lower trays to account for palatal expansion and upper and lower jaw development. The oral appliance includes first and second adjustable hinge arms that are removably connected to the upper and lower trays so that the oral appliance advances the mandible to provide temporary relief from sleep disordered breathing, sleep apnea and/or snoring.

Abstract: Described herein is an oral appliance. The oral appliance includes upper and lower trays that each include at least one axial spring configured to contact a palatal/lingual surface of at least one tooth, where each axial spring is coupled to the respective upper or lower tray, and where each axial spring is configured to produce and transmit intermittent, cyclic forces to the palatal/lingual surface of the tooth to promote palatal and upper/lower jaw development. The upper and lower trays each include an expansion mechanism to enable adjustment of the size of the upper and lower trays to account for palatal expansion and upper and lower jaw development. The oral appliance includes first and second adjustable hinge arms that are removably connected to the upper and lower trays so that the oral appliance advances the mandible to provide temporary relief from sleep disordered breathing, sleep apnea and/or snoring.

Abstract: Described herein is an oral appliance. The oral appliance includes upper and lower trays that each include at least one axial spring configured to contact a palatal/lingual surface of at least one tooth, where each axial spring is coupled to the respective upper or lower tray, and where each axial spring is configured to produce and transmit intermittent, cyclic forces to the palatal/lingual surface of the tooth to promote palatal and upper/lower jaw development. The upper and lower trays each include an expansion mechanism to enable adjustment of the size of the upper and lower trays to account for palatal expansion and upper and lower jaw development. The oral appliance includes first and second adjustable positioners positioned on the upper tray and fins formed integrally on the lower tray so that the oral appliance advances the mandible to provide temporary relief from sleep disordered breathing, sleep apnea and/or snoring.

Abstract: Described herein is an oral appliance. The oral appliance includes upper and lower trays that each include at least one axial spring configured to contact a palatal/lingual surface of at least one tooth, where each axial spring is coupled to the respective upper or lower tray, and where each axial spring is configured to produce and transmit intermittent, cyclic forces to the palatal/lingual surface of the tooth to promote palatal and upper/lower jaw development. The upper and lower trays each include an expansion mechanism to enable adjustment of the size of the upper and lower trays to account for palatal expansion and upper and lower jaw development. The oral appliance includes first and second adjustable hinge arms that are removably connected to the upper and lower trays so that the oral appliance advances the mandible to provide temporary relief from sleep disordered breathing, sleep apnea and/or snoring.

Abstract: A computer implemented method for rendering a page that includes one or more dynamic design elements into an output video is described. The method comprises processing the page to generate one or more layers, each layer being either a static layer associated with one or more static design elements of the page or a dynamic layer associated with a single dynamic design element of the page. Output frames are then generated using the layers and then encoded into the output video.

Abstract: In an immersed membrane system, the influent flows into an open membrane tank. The membrane tank can have multiple horizontally spaced immersed membrane units. The immersed membrane units may have flat sheet membrane elements within a membrane case. One or more ducts are provided in the tank for directing the flow of influent to the immersed membrane units. In some examples, the influent is divided into sub-streams that are fed through baffles to a corresponding immersed membrane unit, optionally in generally equal amounts, optionally in a single pass flow pattern. In a process of operating a membrane tank, the influent flow is directed across the bottom of the membrane tank and divided into multiple portions. Each of the multiple portions is fed directly to the bottom of a corresponding immersed membrane unit located in the tank. The influent may be mixed liquor in a membrane bioreactor (MBR).

Abstract: A method for the manufacture of an oxygen reduction reaction (ORR) catalyst, the method comprising; providing a metal organic framework (MOF) material having a specific internal pore volume of 0.7 cm3g?1 or greater; providing a source of iron and/or cobalt; pyrolysing the MOF material together with the source of iron and/or cobalt to form the catalyst, wherein the MOF material comprises nitrogen and/or the MOF material is pyrolysed together with a source of nitrogen and the source of iron and/or cobalt is disclosed.

Abstract: A gas treatment apparatus, suitable for use in an air purifying apparatus for the production of breathable air, includes a catalyst including palladium and iron oxide and a source of a volatile nitrogen-containing compound. The apparatus is useful in gas masks, emergency escape hoods and static air treatment apparatus.

Abstract: A method for the manufacture of an oxygen reduction reaction (ORR) catalyst, the method comprising; providing a metal organic framework (MOF) material having a specific internal pore volume of 0.7 cm3g?1 or greater; providing a source of iron and/or cobalt; pyrolysing the MOF material together with the source of iron and/or cobalt to form the catalyst, wherein the MOF material comprises nitrogen and/or the MOF material is pyrolysed together with a source of nitrogen and the source of iron and/or cobalt is disclosed.

Abstract: Systems and methods are provided herein for gas storage and the safe release of gas using cascading burst discs. A vessel for storing gas is in pneumatic communication with a first flow path. A first burst disc is disposed in the first flow path such that gas flow is prevented when the disc is intact. A second flow path is in pneumatic communication with the first flow path and configured to receive gas flow when the first burst disc is ruptured. A second burst disc is disposed in the second flow path and configured to prevent a gas flow while the second burst disc is intact. At an operating pressure, the first burst disc may be punctured by an operator allowing normal use of the system. In the event of a gas overpressure, the first and second burst discs will rupture permitting safe release of the gas.

Abstract: A printing device, including a fuser section for printing operations and first and second fuser rollers for the fuser section arranged to: displace a plurality of sheets of print material in a process direction; and substantially simultaneously disengage from a trailing edge of a first sheet from the plurality of sheets; and engage a leading edge of a second sheet from the plurality of sheets. A printing device, including: a fuser section for printing operations and including first and second fuser rollers; a motor arranged to rotate the first and second fuser rollers to displace a plurality of sheets of material in a process direction; and a control system configured to measure a torque produced by the motor and according to a value of the measured torque, control a speed at which the first and second fuser rollers displace the plurality of sheets of print material in the process direction.

Abstract: A printing device, including a fuser section for printing operations and first and second fuser rollers for the fuser section arranged to: displace a plurality of sheets of print material in a process direction; and substantially simultaneously disengage from a trailing edge of a first sheet from the plurality of sheets; and engage a leading edge of a second sheet from the plurality of sheets. A printing device, including: a fuser section for printing operations and including first and second fuser rollers; a motor arranged to rotate the first and second fuser rollers to displace a plurality of sheets of material in a process direction; and a control system configured to measure a torque produced by the motor and according to a value of the measured torque, control a speed at which the first and second fuser rollers displace the plurality of sheets of print material in the process direction.

Abstract: Systems and methods are provided herein for gas storage and the safe release of gas using cascading burst discs. A vessel for storing gas is in pneumatic communication with a first flow path. A first burst disc is disposed in the first flow path such that gas flow is prevented when the disc is intact. A second flow path is in pneumatic communication with the first flow path and configured to receive gas flow when the first burst disc is ruptured. A second burst disc is disposed in the second flow path and configured to prevent a gas flow while the second burst disc is intact. At an operating pressure, the first burst disc may be punctured by an operator allowing normal use of the system. In the event of a gas overpressure, the first and second burst discs will rupture permitting safe release of the gas.

Abstract: A gas treatment apparatus, suitable for use in an air purifying apparatus for the production of breathable air, includes a catalyst including palladium and iron oxide and a source of a volatile nitrogen-containing compound. The apparatus is useful in gas masks, emergency escape hoods and static air treatment apparatus.

Abstract: An apparatus for deploying oxygen masks that includes a pre-packaged modular system that does not require manual repacking of oxygen masks by aircraft technicians. The cartridge is for use with a manifold having a passageway in fluid communication with a source of breathable gas. The cartridge includes an end wall, a sidewall extending from the end wall and terminating at a distal end adjacent to an opening. A flexible member defines a chamber inside the cartridge. The chamber is in fluid communication with the passageway when the cartridge is coupled to the manifold. The flexible member has an outlet. A mask assembly is disposed inside the cartridge. The mask assembly has a hose coupled to the outlet of the flexible member. A cover is removably attached to the distal end of the at least one side wall.

Abstract: A high tarnish resistant silver alloy composition formulated for jewelry and flatware manufacture is provided. In certain implementations, the alloy contains about 92%-97% by weight silver, about 0.25%-3.5% by weight palladium, about 0%-3.5% by weight platinum, about 0%-2.5% by weight gold, about 0.1%-1.0% by weight copper, about 0.5%-3.5% by weight zinc, about 0.1%-1.5% by weight tin, about 0.25%-1.5% by weight indium, about 0.03%-1.1% by weight silicon, about 0%-0.5% by weight germanium, about 0.15%-0.5% by weight gallium, about 0.25%-0.5% by weight cobalt and about 0%-0.5% by weight ruthenium. These unique combinations of elements result in the alloys with the tarnish resistance superior to typical 10K gold alloy.