Abstract: A system is disclosed that is designed to be connected to an electrical power supply. The system comprises a plurality of electric load component comprising stages for cooperatively producing an output (Tout), each stage in a first subset of the stages comprising at least one electrical load component having a first load and each stage in a second subset of the stages comprising at least one electrical load component having a second load, the first load being larger than the second load. The system has a controller for controlling the electrical load components. The controller is designed to estimate voltage variations on the electrical power supply from the switching frequencies of the respective electrical load components during a predefined time frame.

Abstract: A dispensing system for injecting a fluid into a number of containers. The dispensing system may include a turret plate for holding the containers and an injection system positioned about the turret plate. The injection system may include a piston for contacting a container. The piston may include an injection surface in communication with an internal spring such that the internal spring forces the injection surface against the container.

Abstract: The present invention is a protective facial garment which overcomes the problems inherent in garments that cover the face and nose. Namely, the invention addresses the problems of causing eyewear to fog from exhaled breath and having to choose between leaving the mouth and nose exposed versus covering the mouth and nose, which often results in exhaled moisture being held against the skin, causing discomfort. To address these challenges, the device is tailored to provide a vented air pocket in front of the wearer's mouth and nose and to block the natural cavity between the bridge of the wearer's nose and cheekbone. The device thus provides an alternative route for exhaled air, preventing fogging of eyewear. The air pocket provides the further benefit of warming and moistening fresh air, making breathing easier when used in cold air conditions.

Abstract: In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating breast cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.

Abstract: A remotely controlled unit providing three degrees of actuation (rotational, perpendicular to a long axis, parallel to a long axis) of a variety of attachments to assist in the inspection, measurement, lining, and repair of pipe lines. The degrees of actuation are accomplished using a hydraulic system having a hydraulic pump, reservoir, solenoid actuated automatic valves, pistons, and cylinders inside the body of the unit. The components are designed to operate in a partially to fully submersed environment. The unit has an on board camera system that allows an operator the ability to monitor the attachments. In addition to the degrees of actuation, the unit carries a hydraulic clamp that secures the robot in the pipe during its various operations. The unit is controlled and cameras viewed through a control cable that connects the unit to an above ground control station consisting of micro control boards controlled by a CPU.

Abstract: In one aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.

Abstract: In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating breast cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.

Abstract: A dispensing system for injecting a fluid into a number of containers. The dispensing system may include a turret plate for holding the containers and an injection system positioned about the turret plate. The injection system may include a piston for contacting a container. The piston may include an injection surface in communication with an internal spring such that the internal spring forces the injection surface against the container.

Abstract: A system is disclosed that is designed to be connected to an electrical power supply. The system comprises a plurality of electric load component comprising stages for cooperatively producing an output (Tout), each stage in a first subset of the stages comprising at least one electrical load component having a first load and each stage in a second subset of the stages comprising at least one electrical load component having a second load, the first load being larger than the second load. The system has a controller for controlling the electrical load components. The controller is designed to estimate voltage variations on the electrical power supply from the switching frequencies of the respective electrical load components during a predefined time frame.

Abstract: In one aspect, the present invention provides a composition and a kit comprising a combination of topoisomerase inhibitor and PARP inhibitor for treatment of cancer. In another aspect, the invention provides a method of treating cancer comprising administering to a subject a combination of topoisomerase inhibitor and PARP inhibitor. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase and a topoisomerase, as well as providing formulations and modes of administering such compositions.

Abstract: In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating breast cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.

Abstract: In one aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.

Abstract: An embodiment provides a shift inhibitor apparatus. At least a portion of the range actuating assembly is moveable between a range first ratio and a range second ratio. The portion of the range actuating assembly is moveable, at least in part, in response to a fluid pressure. The range chamber is selectively in fluid communication with a vent. The shift inhibitor includes a main section neutral interlock having an interlock chamber. At least a portion of the main section neutral interlock is moveable between a first condition and a second condition. The interlock chamber is selectively in fluid communication with the vent. The range chamber can be exhausted such that the range section is selectively switched from the first ratio to the second ratio. The interlock chamber can be exhausted such that the main section neutral interlock is selectively switched from the first condition to the second condition.

Abstract: A foamed beverage system for creating foamed beverages from a powder, a liquid, and air. The foamed beverage system may include a mixing chamber having a mixing zone and a pressurized zone. An impeller is positioned between the mixing zone and the pressurized zone. The powder and the liquid are added to the mixing chamber and the air is entrained within the mixture of the powder and the liquid within the pressurized zone.

Abstract: A method of heating an amount of material positioned within a receptacle. The method may include heating a first volume of water to a predetermined temperature, pressurizing a first volume of steam to a predetermined pressure, releasing the first volume of steam towards the first volume of water so as to force the first volume of water into the receptacle, and heating the material within the receptacle.

Abstract: A foamed milk system for creating foamed milk from a source of milk, a source of air, and a source of steam. The system may include a milk inlet system for pressurizing the milk, an air inlet system for pressurizing the air, a mixing area to mix the pressurized milk, the pressurized air, and the steam, and an expansion area to expand the mixture of the pressurized milk, the pressurized air, and the steam.

Abstract: Synthetic transmit aperture is provided for three-dimensional ultrasound imaging. A transducer may have separate transmit and receive elements. Broad beams are transmitted, allowing fewer transmit elements and/or more rapid scanning. A multidimensional receive array generates data in response to sequential transmissions, such as transmissions from different angles. The data is combined to increase resolution. A transducer array with offset transmit elements for forming a transmit line source may be used.

Abstract: The subject invention is directed to a method and system for selecting and purchasing media advertising in a user/server environment accessed through a Web site. The method includes accessing a server system through a Web site by an advertiser in which the advertiser provides information relating to buying criteria and customer data through a form on the Web page in order to select and purchase media advertising. The server system receives and processes the information in order to create at least one media advertising rate request. The server system transmits the rate request to at least one media outlet for processing. The media outlet processes the rate request and transmits the processed rate request to the server system. The server system manipulates the processed rate request to create a media advertising schedule and then transmits the advertising schedule to the advertiser.

Abstract: Adaptive line synthesis is provided. Line synthesis of collinear receive beams responsive to spatially distinct transmit beams is a function of many parameters, such as spatial or temporal frequency response of one or more of the receive beams, synthesis function, number of receive beams synthesized, or acquisition sequence. One or more of these parameters is set or adapts as a function of processor estimated or user provided information. By adapting the line synthesis, the performance and image quality is optimized as appropriate for the received data or desired imaging, such as detail resolution, contrast resolution, temporal resolution, shift-invariance and penetration.

Abstract: A method is provided to improve the frame-rate in color-flow ultrasound imaging using simultaneous spatially-distinct transmit beams with one or more frequency bands per transmit beam. Pulses of different center frequencies are used simultaneously in different (lateral and/or elevational) directions, thereby reducing the scanning time and improving the frame-rates. Optionally, a multi-modal pulse is used, and flow is estimated separately for the different frequencies. The flow estimates for these pulses are appropriately combined to improve low-velocity sensitivity and to reduce aliasing. A flow sample count with two or more different pulse repetition intervals can be used to further improve low-flow sensitivity and minimize aliasing.