Patents by Inventor Charles E. Nakamura
Charles E. Nakamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9447385Abstract: From a bacterial strain isolated from an environmental sample, after enrichment in medium containing 1-butanol as the carbon source, a new enzyme with butanol dehydrogenase activity was identified. The enzyme can convert butyraldehyde to 1-butanol, isobutyraldehyde to isobutanol, as well as 2-butanone to 2-butanol and thus is useful for biosynthesis of butanol in recombinant microbial hosts producing these substrates. The encoding gene, named sadB, was isolated from the strain identified as an isolate of Achromobacter xylosoxidans.Type: GrantFiled: February 13, 2014Date of Patent: September 20, 2016Assignee: Butamax Advanced Biofuels LLCInventors: Michael G. Bramucci, Andrew C. Eliot, Lori Ann Maggio-Hall, Charles E. Nakamura
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Patent number: 9297028Abstract: Methods for the fermentive production of four carbon alcohols is provided. Specifically, butanol, preferably 1-butanol is produced by the fermentive growth of a recombinant bacterium expressing a 1-butanol biosynthetic pathway.Type: GrantFiled: September 27, 2006Date of Patent: March 29, 2016Assignee: Butamax Advanced Biofuels LLCInventors: Gail K. Donaldson, Lixuan Lisa Huang, Lori Ann Maggio-Hall, Vasantha Nagarajan, Charles E. Nakamura, Wonchul Suh
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Patent number: 8980612Abstract: Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein.Type: GrantFiled: May 27, 2009Date of Patent: March 17, 2015Assignee: Butamax Advanced Biofuels LLCInventors: Gail K. Donaldson, Andrew C. Eliot, Vasantha Nagarajan, Charles E. Nakamura, Jean-Francois Tomb
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Patent number: 8962298Abstract: Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein.Type: GrantFiled: April 30, 2007Date of Patent: February 24, 2015Assignee: Butamax Advanced Biofuels LLCInventors: Gail K. Donaldson, Andrew C. Eliot, Vasantha Nagarajan, Charles E. Nakamura, Jean-Francois Tomb
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Patent number: 8828704Abstract: Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein. Specifically disclosed herein are the use of coenzyme B12-independent butanediol dehydratases that catalyzes the substrate to product conversion of 2,3-butanediol to 2-butanone in the process of producing 2-butanol and 2-butanone.Type: GrantFiled: April 29, 2008Date of Patent: September 9, 2014Assignee: Butamax Advanced Biofuels LLCInventors: Gail K. Donaldson, Andrew C. Eliot, Lori Ann Maggio-Hall, Vasantha Nagarajan, Charles E. Nakamura, Jean-Francois Tomb
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Publication number: 20140170732Abstract: From a bacterial strain isolated from an environmental sample, after enrichment in medium containing 1-butanol as the carbon source, a new enzyme with butanol dehydrogenase activity was identified. The enzyme can convert butyraldehyde to 1-butanol, isobutyraldehyde to isobutanol, as well as 2-butanone to 2-butanol and thus is useful for biosynthesis of butanol in recombinant microbial hosts producing these substrates. The encoding gene, named sadB, was isolated from the strain identified as an isolate of Achromobacter xylosoxidans.Type: ApplicationFiled: February 13, 2014Publication date: June 19, 2014Applicant: BUTAMAX ADVANCED BIOFUELS LLCInventors: Michael G. Bramucci, Andrew C. Eliot, Lori Ann Maggio-Hall, Charles E. Nakamura
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Patent number: 8691540Abstract: From a bacterial strain isolated from an environmental sample, after enrichment in medium containing 1-butanol as the carbon source, a new enzyme with butanol dehydrogenase activity was identified. The enzyme can convert butyraldehyde to 1-butanol, isobutyraldehyde to isobutanol, as well as 2-butanone to 2-butanol and thus is useful for biosynthesis of butanol in recombinant microbial hosts producing these substrates. The encoding gene, named sadB, was isolated from the strain identified as an isolate of Achromobacter xylosoxidans.Type: GrantFiled: May 24, 2012Date of Patent: April 8, 2014Assignee: Butamax Advanced Biofuels LLCInventors: Michael G. Bramucci, Andrew C. Eliot, Lori Ann Maggio-Hall, Charles E. Nakamura
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Publication number: 20120231515Abstract: From a bacterial strain isolated from an environmental sample, after enrichment in medium containing 1-butanol as the carbon source, a new enzyme with butanol dehydrogenase activity was identified. The enzyme can convert butyraldehyde to 1-butanol, isobutyraldehyde to isobutanol, as well as 2-butanone to 2-butanol and thus is useful for biosynthesis of butanol in recombinant microbial hosts producing these substrates. The encoding gene, named sadB, was isolated from the strain identified as an isolate of Achromobacter xylosoxidans.Type: ApplicationFiled: May 24, 2012Publication date: September 13, 2012Applicant: Butamax(TM) Advanced Biofuels LLCInventors: MICHAEL G. BRAMUCCI, Andrew C. Eliot, Lori Ann Maggio-Hall, Charles E. Nakamura
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Publication number: 20120196341Abstract: Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein.Type: ApplicationFiled: October 26, 2011Publication date: August 2, 2012Applicant: BUTAMAX(TM) ADVANCED BIOFUELS LLCInventors: Gail K. Donaldson, Andrew C. Eliot, Vasantha Nagarajan, Charles E. Nakamura, Lixuan Lisa Huang
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Patent number: 8188250Abstract: From a bacterial strain isolated from an environmental sample, after enrichment in medium containing 1-butanol as the carbon source, a new enzyme with butanol dehydrogenase activity was identified. The enzyme can convert butyraldehyde to 1-butanol, isobutyraldehyde to isobutanol, as well as 2-butanone to 2-butanol and thus is useful for biosynthesis of butanol in recombinant microbial hosts producing these substrates. The encoding gene, named sadB, was isolated from the strain identified as an isolate of Achromobacter xylosoxidans.Type: GrantFiled: April 27, 2009Date of Patent: May 29, 2012Assignee: Butamax(TM) Advanced Biofuels LLCInventors: Michael G. Bramucci, Andrew C. Eliot, Lori Ann Maggio-Hall, Charles E. Nakamura
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Publication number: 20090305369Abstract: An E. coli host strain was engineered wherein genes adhE, IdhA, frdB, and pfIB were disrupted and novel butanol dehydrogenase gene, sadB, from Achromobacter xylosoxidans, was added to produce the isobutanol production host.Type: ApplicationFiled: June 4, 2009Publication date: December 10, 2009Applicant: E.I.DU PONT DE NEMOURS AND COMPANYInventors: Gail K. Donaldson, Lori Ann Maggio-Hall, Charles E. Nakamura
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Publication number: 20090269823Abstract: From a bacterial strain isolated from an environmental sample, after enrichment in medium containing 1-butanol as the carbon source, a new enzyme with butanol dehydrogenase activity was identified. The enzyme can convert butyraldehyde to 1-butanol, isobutyraldehyde to isobutanol, as well as 2-butanone to 2-butanol and thus is useful for biosynthesis of butanol in recombinant microbial hosts producing these substrates. The encoding gene, named sadB, was isolated from the strain identified as an isolate of Achromobacter xylosoxidans.Type: ApplicationFiled: April 27, 2009Publication date: October 29, 2009Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventors: Michael G. Bramucci, Andrew C. Eliot, Lori Ann Maggio-Hall, Charles E. Nakamura
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Publication number: 20090239275Abstract: Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein.Type: ApplicationFiled: May 27, 2009Publication date: September 24, 2009Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventors: Gail K. Donaldson, Andrew C. Eliot, Vasantha Nagarajan, Charles E. Nakamura, Jean-Francois Tomb
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Publication number: 20090155870Abstract: Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein. Specifically disclosed herein are the use of coenzyme B12-independent butanediol dehydratases that catalyzes the substrate to product conversion of 2,3-butanediol to 2-butanone in the process of producing 2-butanol and 2-butanone.Type: ApplicationFiled: April 29, 2008Publication date: June 18, 2009Inventors: GAIL K. DONALDSON, Andrew C. Eliot, Lori Ann Maggio-Hall, Vasantha Nagarajan, Charles E. Nakamura, Jean-Francois Tomb
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Publication number: 20080182308Abstract: Methods for the fermentive production of four carbon alcohols is provided. Specifically, butanol, preferably 1-butanol is produced by the fermentive growth of a recombinant bacterium expressing a 1-butanol biosynthetic pathway.Type: ApplicationFiled: September 27, 2006Publication date: July 31, 2008Inventors: Gail K. Donaldson, Lixuan Lisa Huang, Lori Ann Maggio-Hall, Vasantha Nagarajan, Charles E. Nakamura, Wonchul Suh
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Patent number: 6013494Abstract: Recombinant organisms are provided comprising genes encoding glycerol-3-phosphate dehydrogenase, glycerol-3-phosphatase, glycerol dehydratase and 1,3-propanediol oxidoreductase activites useful for the production of 1,3-propanediol from a variety of carbon substrates.Type: GrantFiled: November 12, 1997Date of Patent: January 11, 2000Assignees: E. I. du Pont de Nemours and Company, Genencor InternationalInventors: Charles E. Nakamura, Anthony A. Gatenby, Amy Kuang-Hua Hsu, Richard D. La Reau, Sharon L. Haynie, Maria Diaz-Torres, Donald E. Trimbur, Gregory M. Whited, Vasantha Nagarajan, Mark S. Payne, Stephen K. Picataggio, Ramesh V. Nair
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Patent number: 5633362Abstract: A process is provided for the bioconversion of glycerol to 1,3-propanediol in which genes from a bacteria known to possess a diol dehydratase enzyme for 1,2-propanediol degradation are cloned into a bacterial host and the host is grown in the presence of glycerol; expression of the foreign genes in the host cell facilitates the enzymatic conversion of glycerol to 1,3-propanediol which is isolated from the culture.Type: GrantFiled: May 12, 1995Date of Patent: May 27, 1997Assignee: E. I. Du Pont de Nemours and CompanyInventors: Vasantha Nagarajan, Charles E. Nakamura
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Patent number: 5466801Abstract: A process for the preparation of 3- and/or 6-substituted 2,5-morpholinediones is disclosed. Such morpholinediones are useful as precursors for the preparation of depsipeptide polymers and copolymers.Type: GrantFiled: August 26, 1993Date of Patent: November 14, 1995Assignee: E. I. Du Pont de Nemours and CompanyInventors: Charles E. Nakamura, Robert Di Cosimo, John R. Moran
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Patent number: 5371001Abstract: This invention concerns esters of unsymmetrically 2-substituted glycolic acid dimers, a process for their preparation and their use in the preparation of unsymmetrically 3,6-substituted 1,4-dioxane-2,5-diones.Type: GrantFiled: July 6, 1993Date of Patent: December 6, 1994Assignee: E. I. Du Pont de Nemours and CompanyInventors: David L. Anton, Charles E. Nakamura
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Patent number: 5326887Abstract: This invention relates to a process for preparing 1,4-dioxane-2,5-diones comprising reacting an .alpha.-hydroxy acid oligomer or an ester of an .alpha.-hydroxy acid oligomer over a fixed bed catalyst system.Type: GrantFiled: February 14, 1992Date of Patent: July 5, 1994Assignee: E. I. Du Pont de Nemours and CompanyInventors: Robert Di Cosimo, John R. Moran, Charles E. Nakamura