Patents by Inventor Charles Edward Prussak

Charles Edward Prussak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Packaging cell lines for pseudotyped retroviral vectors
    Patent number: 5739018
    Abstract: The present invention features packaging cell lines and recombinant retroviral particles produced thereby, particularly pseudotyped retroviral particles. Preferably, the packaging cell lines are derived from HeLa, Cf2Th, D17, MDCK, or BHK cells, most preferably from Cf2Th cells. Retroviral particles are produced by inducibly expressing an envelope protein of interest (e.g., a retroviral envelope or the envelope protein of vesicular stomatitis virus (VSV G)). Inducible expression of the envelope protein is accomplished by operably linking an envelope protein-encoding nucleotide sequence to an inducible promoter (e.g., a promoter composed of a minimal promoter linked to multiple copies of tetO, the binding site for the tetracycline repressor (tetR) of the Escherichia coli, tetracycline resistance operon Tn10).
    Type: Grant
    Filed: August 7, 1996
    Date of Patent: April 14, 1998
    Assignees: The Regents of the University of California, City of Hope
    Inventors: Atsushi Miyanohara, Jiing-Kuan Yee, Shin-Tai Chen, Charles Edward Prussak, Theodore Friedmann