Patents by Inventor Charles F. Jewell

Charles F. Jewell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ligand-directed covalent modification of protein
    Patent number: 11542492
    Abstract: The present invention relates to enzyme inhibitors. More specifically, the present invention relates to ligand-directed covalent modification of proteins; method of designing same; pharmaceutical formulation of same; and method of use.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: January 3, 2023
    Assignee: Celgene CAR LLC
    Inventors: Russell C. Petter, Charles F. Jewell, Kwangho Lee, Aravind Prasad Medikonda, Deqiang Niu, Lixin Qiao, Juswinder Singh, Zhendong Zhu
  • Ligand-Directed Covalent Modification of Protein
    Publication number: 20170218353
    Abstract: The present invention relates to enzyme inhibitors. More specifically, the present invention relates to ligand-directed covalent modification of proteins; method of designing same; pharmaceutical formulation of same; and method of use.
    Type: Application
    Filed: February 2, 2017
    Publication date: August 3, 2017
    Inventors: Russell C. Petter, Charles F. Jewell, Kwangho Lee, Aravind Prasad Medikonda, Deqiang Niu, Lixin Qiao, Juswinder Singh, Zhendong Zhu
  • LIGAND-DIRECTED COVALENT MODIFICATION OF PROTEIN
    Publication number: 20110269244
    Abstract: The present invention relates to enzyme inhibitors. More specifically, the present invention relates to ligand-directed covalent modification of proteins; method of designing same; pharmaceutical formulation of same; and method of use.
    Type: Application
    Filed: December 30, 2010
    Publication date: November 3, 2011
    Inventors: Russell C. Petter, Charles F. Jewell, Kwangho Lee, Aravind Prasad Medikonda, Deqiang Niu, Lixin Qiao, Juswinder Singh, Zhendong Zhu
  • Preparation of lactones
    Patent number: 4677211
    Abstract: 7-Substituted lower alkyl hept-6-enoates and 4-hydroxytetrahydropyran-2-ones bearing 6-olefinic substituents (e.g.,) ethyl erythro-3,5-dihydroxy-7-phenyl-hept-6-enoates are prepared by a multi-step process. The process involves 3-protected-lower alkyl 3,5-dihydroxy-hept-6-enoates, which are obtained by cleaving corresponding 6.alpha.-vinyl-4.beta.-protected hydroxy-tetrahydro 2H-pyran-2-ones. The final products are useful as anti hypercholesteremic agents.
    Type: Grant
    Filed: July 26, 1985
    Date of Patent: June 30, 1987
    Assignee: Sandoz Pharmaceuticals Corp.
    Inventors: Charles F. Jewell, Jr., James R. Wareing
  • Preparation of olefinic compounds and intermediates thereof
    Patent number: 4650890
    Abstract: 7-Substituted lower alkyl hept-6-enoates and 4-hydroxy-tetrahydropyran-2-ones bearing 6-olefinic substituents (E), (Z), ethyl erythro-3,5-dihydroxy-7-phenyl-hept-6-enates are prepared by a multi-step process involving lower alkyl 3,5-dihydroxy-hept-6-enates. The final products are useful as anti hypercholesteremic agents.
    Type: Grant
    Filed: July 26, 1985
    Date of Patent: March 17, 1987
    Assignee: Sandoz Corp.
    Inventors: Charles F. Jewell, Jr., James R. Wareing
  • 4-trisubstituted silyl protected hydroxy-6-oxo-tetrahydropyran-2-yl-aldehyde intermediates
    Patent number: 4625039
    Abstract: 6-trans-indol-2-yl-ethenyl)-4-hydroxy-tetrahydro-2H-pyran-2-ones of formula I are obtained by a multi-step reaction involving the procedure: ##STR1## wherein p.sup.1 is trisubstituted silyl protective group, and Z is a 2-indolyl radical which may be bear at the 4, 5, 6 and 7-positions up to two substituents such as alkyl, alkoxy, halo and CF.sub.3, and at either one the 1 or 3-positions a substituted or unsubstituted phenyl; and at the other an assymetric alkyl, cycloalkyl or aralkyl radical. Compounds I, e.g. (E)-trans-6-[1'-methyl-3'-(4"-fluorophenyl)indol-2'-ylethenyl]3,4,5,6 -tetrahydro-4-hydroxy-2H-pyran-2-one(4R,6S); are useful as anti-atheroselerotic agents.
    Type: Grant
    Filed: December 21, 1983
    Date of Patent: November 25, 1986
    Assignee: Sandoz Pharm. Corp.
    Inventors: Charles F. Jewell, Jr., James R. Wareing