Abstract: In one aspect, the disclosure relates to substituted N-(2-(2,6-dioxopiperidinyl-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs that useful as modulators of cereblon (CRBN) activity, methods of making same, pharmaceutical compositions comprising same, and methods of treating various clinical conditions and disorders using same, e.g., a disorder of uncontrolled cellular proliferation, such as a cancer, which may be associated with cereblon protein dysfunction and/or a GSPT1 dysfunction. In various further aspects, the disclosed compounds can selectively modulate the degradation of GSPT1 protein, i.e., the disclosed compounds can act as GSPT1 degraders. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Described herein are methods of preparing compounds derived from triglycerides or condensation polymers such as polyesters and/or polyamides. The methods may include subjecting triglyceride or condensation polymer containing matter to mechanical processing in the presence of a nucleophile.

Abstract: An expandable spinal implant includes a distal projection extending from only one side of the implant, ending in an anterior tip, the anterior portion and anterior tip defining an elongated distal end hook, which is wider than the proximal end. The distal end hook rotates around the spinal cord, aligning the implant with a desired pathway, then inserts into place in the disc space between the vertebrae. The elongated widened distal end hook provides a TLIF approach, distributes loads, provides anterior rim engagement, and creates lordosis.

Abstract: An expandable spinal implant includes a distal projection extending from only one side of the implant, ending in an anterior tip, the anterior portion and anterior tip defining an elongated distal end hook, which is wider than the proximal end. The distal end hook rotates around the spinal cord, aligning the implant with a desired pathway, then inserts into place in the disc space between the vertebrae. The elongated widened distal end hook provides a TLIF approach, distributes loads, provides anterior rim engagement, and creates lordosis.

Abstract: A surgical instrument having a first member engageable with a first end of a fastener having a second end configured to penetrate tissue. A second member includes an expandable member configured for engaging the first end. Systems and methods are disclosed.

Abstract: A surgical instrument having a first member engageable with a first end of a fastener having a second end configured to penetrate tissue. A second member includes an expandable member configured for engaging the first end. Systems and methods are disclosed.

Abstract: The system includes a detection unit configured to obtain sensor data of an environment (e.g., a massage therapy facility, a doctor's office, etc.), where the sensor data relates to the movements and actions of a first individual (e.g., a practitioner) and/or a second individual (e.g., the practitioner's patent) in relation to each other. The system is used to monitor the actions of the individuals so as to detect inappropriate behavior by the first individual and/or the second individual (e.g., inappropriate touching or hand placement, groping, etc.). The system can be configured to detect inappropriate behavior without capturing personally identifying images and/or videos of the individuals.

Abstract: An expandable spinal implant includes a distal projection extending from only one side of the implant, ending in an anterior tip, the anterior portion and anterior tip defining an elongated distal end hook, which is wider than the proximal end. The distal end hook rotates around the spinal cord, aligning the implant with a desired pathway, then inserts into place in the disc space between the vertebrae. The elongated widened distal end hook provides a TLIF approach, distributes loads, provides anterior rim engagement, and creates lordosis.

Abstract: An expandable spinal implant includes a distal projection extending from only one side of the implant, ending in an anterior tip, the anterior portion and anterior tip defining an elongated distal end hook, which is wider than the proximal end. The distal end hook rotates around the spinal cord, aligning the implant with a desired pathway, then inserts into place in the disc space between the vertebrae. The elongated widened distal end hook provides a TLIF approach, distributes loads, provides anterior rim engagement, and creates lordosis.

Abstract: A computer implemented method of building a training set for training an AI program for document classification is provided. The method comprises, in relation to a first training set comprising a set of documents classified as positive, and therefore of interest to a user, or negative, and therefore not of interest to the user, the steps of: receiving a selection of a search algorithm for obtaining further documents; obtaining, based upon the selected algorithm, a plurality of documents; presenting a selected subset of the documents to the user; receiving user input, wherein the user input is a user classification of whether one or more of the presented documents are positive or negative; adding the user classified documents to the training set to create a second training set; and repeating, until the training set is considered complete, the above steps, wherein the second training set is then used as the first training set.

Abstract: A valve assembly for an artificial lift system can include a cage defining a bore therethrough, a valve seat, and a ball disposed within the cage. In a closed position, the ball seals against the valve seat. Upon application of sufficient pressure, the ball lifts from the valve seat to open the valve and allow fluid to flow through the bore. An interior surface of the cage surrounding the bore includes a flow profile that improves fluid flow through the cage. The flow profile can include a plurality of flanges protruding inwardly into the bore from the interior surface and extending helically along a longitudinal length of the cage.

Abstract: An expandable spinal implant includes a distal projection extending from only one side of the implant, ending in an anterior tip, the anterior portion and anterior tip defining an elongated distal end hook, which is wider than the proximal end. The distal end hook rotates around the spinal cord, aligning the implant with a desired pathway, then inserts into place in the disc space between the vertebrae. The elongated widened distal end hook provides a TLIF approach, distributes loads, provides anterior rim engagement, and creates lordosis.

Abstract: A surgical instrument having a first member engageable with a first end of a fastener having a second end configured to penetrate tissue. A second member includes an expandable member configured for engaging the first end. Systems and methods are disclosed.

Abstract: The system includes a detection unit configured to obtain sensor data of an environment (e.g., a massage therapy facility, a doctor's office, etc.), where the sensor data relates to the movements and actions of a first individual (e.g., a practitioner) and/or a second individual (e.g., the practitioner's patent) in relation to each other. The system is used to monitor the actions of the individuals so as to detect inappropriate behavior by the first individual and/or the second individual (e.g., inappropriate touching or hand placement, groping, etc.). The system can be configured to detect inappropriate behavior without capturing personally identifying images and/or videos of the individuals.

Abstract: An expandable spinal implant includes a distal projection extending from only one side of the implant, ending in an anterior tip, the anterior portion and anterior tip defining an elongated distal end hook, which is wider than the proximal end. The distal end hook rotates around the spinal cord, aligning the implant with a desired pathway, then inserts into place in the disc space between the vertebrae. The elongated widened distal end hook provides a TLIF approach, distributes loads, provides anterior rim engagement, and creates lordosis.

Abstract: An expandable spinal implant includes a distal projection extending from only one side of the implant, ending in an anterior tip, the anterior portion and anterior tip defining an elongated distal end hook, which is wider than the proximal end. The distal end hook rotates around the spinal cord, aligning the implant with a desired pathway, then inserts into place in the disc space between the vertebrae. The elongated widened distal end hook provides a TLIF approach, distributes loads, provides anterior rim engagement, and creates lordosis.

Abstract: An expandable spinal implant includes a distal projection extending from only one side of the implant, ending in an anterior tip, the anterior portion and anterior tip defining an elongated distal end hook, which is wider than the proximal end. The distal end hook rotates around the spinal cord, aligning the implant with a desired pathway, then inserts into place in the disc space between the vertebrae. The elongated widened distal end hook provides a TLIF approach, distributes loads, provides anterior rim engagement, and creates lordosis.

Abstract: Disclosed are methods for treating catmint oil. The treated catmint oil can be used for the production of hydrogenated catmint oil, which is enriched in the insect repellent, dihydronepetalactone, and from which formulated products may be prepared.

Abstract: The apparatus, systems, and methods described herein may operate to receive information identifying and describing at least one of a set of events, an initial distribution of a plurality of states, an initial transition matrix, or an initial event matrix; generate, based at least in part on the information, at least one intermediate transition matrix and at least one intermediate event matrix describing a sparse Baum-Welch training that allows no event to occur at one or more time steps; and transform the at least one intermediate transition matrix and the at least one intermediate event matrix into a transition matrix and an event matrix describing a continuous-time Baum-Welch training, the continuous-time Baum-Welch training allowing events to occur simultaneously or at sporadic time intervals in a Markov model including a hidden Markov Model (HMM) having more than two hidden states.

Abstract: The apparatus, systems, and methods described herein may operate to receive information identifying and describing at least one of a set of events, an initial distribution of a plurality of states, an initial transition matrix, or an initial event matrix; generate, based at least in part on the information, at least one intermediate transition matrix and at least one intermediate event matrix describing a sparse Baum-Welch training that allows no event to occur at one or more time steps; and transform the at least one intermediate transition matrix and the at least one intermediate event matrix into a transition matrix and an event matrix describing a continuous-time Baum-Welch training, the continuous-time Baum-Welch training allowing events to occur simultaneously or at sporadic time intervals in a Markov model including a hidden Markov Model (HMM) having more than two hidden states.