Abstract: Disclosed is an audio signal processing method implemented by an audio system with internal and external sensors. The internal sensor measures acoustic signals propogating internally to a user's head. The external sensor measures acoustic signals propagating externally to the user's head. The method includes: producing first and second audio signals by measuring simultaneously acoustic signals reaching the internal and external sensors, respectively; filtering the second audio signal by a noise matching filter matching a second noise signal affecting the second audio signal with a first noise signal affecting the first audio signal, wherein the first noise signal and the second noise signal correspond to a same noise acoustic signal originating outside the user's head and measured by respectively the internal and external sensors, thereby producing a filtered second audio signal including a matched second noise signal; and mixing the filtered second audio signal and the first audio signal.

Abstract: A boat lift that may have a first worm screw operably connected to the drive shaft defining an axis of rotation aligned with the drive shaft and operably contacting a first worm gear, the first worm screw and the first worm gear defines a first lifting stage. The boat lift may also have a second worm screw operably connected to the first worm gear and operably contacts a second worm gear, the second worm screw and the second worm gear defines a second lifting stage. The boat lift may have a tapered roller bearing assembly that operably engages the second worm screw, the tapered roller bearing assembly has a first tapered roller bearing secured at a first location proximate a first end of the second worm screw and a second tapered roller bearing secured at a second location proximate a second opposing end of the second worm screw.

Abstract: Disclosed is an audio signal processing method implemented by an audio system including at least an internal sensor, an external sensor and a speaker unit. The audio signal processing method includes: producing internal and external audio signals by measuring simultaneously acoustic signals reaching the internal sensor and acoustic signals reaching the external sensor, respectively; converting the internal audio signal to frequency domain, thereby producing an internal audio spectrum; converting the external audio signal to frequency domain, thereby producing an external audio spectrum; estimating, based on the internal audio spectrum, an echo audio spectrum of an echo audio signal caused by the speaker unit in the external audio signal, wherein the echo audio spectrum is estimated for frequencies above a minimum frequency, wherein the minimum frequency ?600 hertz; and correcting the external audio spectrum for frequencies above the minimum frequency, based on the echo audio spectrum.

Abstract: Disclosed is an audio signal processing method implemented by an audio system with internal and external sensors. The internal sensor measures acoustic signals propogating internally to a user's head. The external sensor measures acoustic signals propagating externally to the user's head. The method includes: producing first and second audio signals by measuring simultaneously acoustic signals reaching the internal and external sensors, respectively; filtering the second audio signal by a noise matching filter matching a second noise signal affecting the second audio signal with a first noise signal affecting the first audio signal, wherein the first noise signal and the second noise signal correspond to a same noise acoustic signal originating outside the user's head and measured by respectively the internal and external sensors, thereby producing a filtered second audio signal including a matched second noise signal; and mixing the filtered second audio signal and the first audio signal.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: A boat lift that may have a first worm screw operably connected to the drive shaft defining an axis of rotation aligned with the drive shaft and operably contacting a first worm gear, the first worm screw and the first worm gear defines a first lifting stage. The boat lift may also have a second worm screw operably connected to the first worm gear and operably contacts a second worm gear, the second worm screw and the second worm gear defines a second lifting stage. The boat lift may have a tapered roller bearing assembly that operably engages the second worm screw, the tapered roller bearing assembly has a first tapered roller bearing secured at a first location proximate a first end of the second worm screw and a second tapered roller bearing secured at a second location proximate a second opposing end of the second worm screw.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: A system and method for accessing a carrier network by a client device. The method includes: receiving a selection of a first plan from a carrier marketplace that includes at least the first plan and a second plan, wherein the first plan corresponds to a first set of services provided by a first carrier network, and the second plan corresponds to a second set of services provided by a second carrier network; downloading a carrier profile from the server device to a multi-profile UICC (Universal Integrated Circuit Card) included in the client device, wherein the carrier profile is associated with the first plan; and storing the carrier profile in the multi-profile UICC.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: A system and method for providing an overlay network is provided. The overlay network comprises a database of underlying wireless networks provided by various carriers. Location information, an associated time and wireless network performance parameters of a plurality of wireless networks are collected from a plurality of client devices. The system and method aggregates the performance parameters based on geographic area and a time window. The performance parameters are analyzed to determine a best performing wireless network within each geographic area during the time window. The best performing wireless network is then assigned as a default wireless network for the geographic area during the time window and stored in the database defining the overlay network. The database is then provided to the plurality of client devices to provide a default wireless network for the plurality of client device to attach to when in that geographic area during the time window.

Abstract: The present invention provides novel bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: The present invention provides novel bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Abstract: This method comprises steps of: a) partitioning (10, 16) the spectrum of the noisy signal into a HF part and a LF part; b) operating denoising processes in a differentiated manner for each of the two parts of the spectrum with, for the HF part, a denoising by prediction of the useful signal from one sensor to the other between sensors of a first sub-array (R1), by means of a first adaptive algorithm estimator (14), and, for the LF part, a denoising by prediction of the noise from one sensor to the other between sensors of a second sub-array (R2), by means of a second adaptive algorithm estimator (18); c) reconstructing the spectrum by combining together (22) the signals delivered after denoising of the two parts of the spectrum, respectively; and d) selectively reducing the noise (24) by an Optimized Modified Log-Spectral Amplitude gain, OM-LSA, process.

Abstract: The present invention provides novel cycloalkyl-substituted pyrimidine dione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: A system and method for accessing a carrier network by a client device. The method includes: receiving a selection of a first plan from a carrier marketplace that includes at least the first plan and a second plan, wherein the first plan corresponds to a first set of services provided by a first carrier network, and the second plan corresponds to a second set of services provided by a second carrier network; downloading a carrier profile from the server device to a multi-profile UICC (Universal Integrated Circuit Card) included in the client device, wherein the carrier profile is associated with the first plan; and storing the carrier profile in the multi-profile UICC.

Abstract: The present invention provides novel cycloalkyl-substituted pyrimidine dione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.