Patents by Inventor Charles G. Glabe

Charles G. Glabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and kits for detecting misfolded proteins
    Patent number: 11125758
    Abstract: Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: September 21, 2021
    Assignees: Yale University, The Regents of the University of California
    Inventors: Catalin S. Buhimschi, Irina Buhimschi, Charles G. Glabe
  • Methods and compositions for eliciting an amyloid-selective immune response
    Patent number: 9535076
    Abstract: The present invention involves methods and compositions for treating, preventing, and diagnosing amyloid-associated diseases and conditions, as well as methods and compositions for making antigens that elicit antibodies which selectively or specifically bind amyloid prefibrillar oligomers or protofibrillar aggregates over monomers or fibrils of the same amyloid.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: January 3, 2017
    Assignee: The Regents of the University of California
    Inventors: Rakez Kayed, Charles G. Glabe
  • METHODS AND KITS FOR DETECTING MISFOLDED PROTEINS
    Publication number: 20160097775
    Abstract: Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.
    Type: Application
    Filed: September 10, 2015
    Publication date: April 7, 2016
    Applicants: Yale University, The Regents of the University of California
    Inventors: Catalin S. Buhimschi, Irina Buhimschi, Charles G. Glabe
  • Methods and kits for detecting misfolded proteins
    Patent number: 9229009
    Abstract: Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.
    Type: Grant
    Filed: November 2, 2009
    Date of Patent: January 5, 2016
    Assignees: Yale University, The Regents of the University of California
    Inventors: Catalin S. Buhimschi, Irina Buhimschi, Charles G. Glabe
  • METHODS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF PREECLAMPSIA
    Publication number: 20110280863
    Abstract: Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.
    Type: Application
    Filed: November 2, 2009
    Publication date: November 17, 2011
    Applicants: Regents of the University of California, The, Yale University
    Inventors: Catalin S. Buhimschi, Irina Buhimschi, Charles G. Glabe
  • METHODS AND COMPOSITIONS FOR ELICITING AN AMYLOID-SELECTIVE IMMUNE RESPONSE
    Publication number: 20110250217
    Abstract: The present invention involves methods and compositions for treating, preventing, and diagnosing amyloid-associated diseases and conditions, as well as methods and compositions for making antigens that elicit antibodies which selectively or specifically bind amyloid prefibrillar oligomers or protofibrillar aggregates over monomers or fibrils of the same amyloid.
    Type: Application
    Filed: July 27, 2009
    Publication date: October 13, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Rakez Kayed, Charles G. Glabe
  • MONOCLONAL ANTIBODIES SPECIFIC FOR PATHOLOGICAL AMYLOID AGGREGATES COMMON TO AMYLOIDS FORMED FROM PROTEINS OF DIFFERING SEQUENCE
    Publication number: 20110200609
    Abstract: Monoclonal antibody compositions, methods of production and use. The monoclonal antibodies are specific to conformational epitope(s) of a prefibrillar aggregate(s) which contribute to amyloid fibril formation in human or animal subjects who suffer from amyloid diseases (e.g., Alzheimer's Disease) and the hybridomas and monoclonal antibodies produced therefrom. The monoclonal antibodies are useable for immunization of human or animal subjects against Alzheimer's Disease or other amyloid diseases and/or for the diagnosis or detection of Alzheimer's Disease or other amyloid diseases. The monoclonal antibodies may be administered concomitantly or in combination with anti-inflammatory agents, such as gold or gold containing compounds, to decrease neural inflammation associated with amyloid diseases (e.g., Alzheimer's Disease).
    Type: Application
    Filed: July 27, 2009
    Publication date: August 18, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Charles G. Glabe, Rakez Kayed
  • Compositions and Methods for Inhibiting Drusen Formation and for Diagnosing or Treating Drusen-Related Disorders
    Publication number: 20110020237
    Abstract: Compositions of matter and methods for inhibiting drusen or drusen-like deposits and/or for treating diseases related to drusen or drusen-like deposits in human or animal subjects by administering to the subject a therapeutically effective amount of i) a conformational epitope of an aggregate that contributes to the formation or biosynthesis of drusen or drusen-like deposits and/or ii) an antibody that binds to a conformational epitope of an aggregate that contributes to the formation or biosynthesis of drusen or the drusen-like deposit.
    Type: Application
    Filed: January 17, 2006
    Publication date: January 27, 2011
    Inventors: Charles G. Glabe, Rakez Kayed, Ralf Langen, Jeannie Chen, Jose Mario Isas, Volker Luibl