Patents by Inventor CHARLES J. BIEBERICH

CHARLES J. BIEBERICH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PIM kinase inhibitors in combination with autophagy inhibitors for treatment of cancers
    Patent number: 11389440
    Abstract: The present invention provides for a method of treating cancer and/or reducing proliferation of cancer cells, the method comprising administering to a subject in need of such treatment a composition comprising a PIM kinase inhibitor that exhibits changes in expressed RNA or ribosomal binding proteins in combination with a compound that inhibits autophagy.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: July 19, 2022
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Charles J. Bieberich, Xiang Li
  • A METHOD FOR ASSEMBLING CIRCULAR AND LINEAR DNA MOLECULES IN AN ORDERED MANNER
    Publication number: 20220090090
    Abstract: The present invention relates to a method of assembling circular and linear DNA molecules, more specifically, the present invention provides for a homology-based, one-tube assembly method including a circular DNA vector and at least one restriction enzyme without prior linearization of such a circular DNA vector.
    Type: Application
    Filed: January 15, 2020
    Publication date: March 24, 2022
    Inventors: CHARLES J. BIEBERICH, XIANG LI
  • PIM kinase inhibitors in combination with RNA splicing modulators/inhibitors for treatment of cancers
    Patent number: 10842785
    Abstract: The present invention provides for a method of treating cancer and/or reducing proliferation of cancer cells, the method comprising administering to a subject in need of such treatment a composition comprising a PIM kinase inhibitor that exhibits changes of mRNA splicing in combination with a compound that modulates/inhibits activity of an RNA splicing factor protein. Further, changes in splicing of mRNAs and phosphorylation of RNA splicing factors can be used as biomarkers for patient responsiveness to anti-PIM treatment and also suggest effective combinatorial therapies, including synergistic combination.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: November 24, 2020
    Assignee: THE UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Charles J. Bieberich, Xiang Li, Tejashree Joglekar
  • PIM KINASE INHIBITORS IN COMBINATION WITH AUTOPHAGY INHIBITORS FOR TREATMENT OF CANCERS
    Publication number: 20200230125
    Abstract: The present invention provides for a method of treating cancer and/or reducing proliferation of cancer cells, the method comprising administering to a subject in need of such treatment a composition comprising a PIM kinase inhibitor that exhibits changes in expressed RNA or ribosomal binding proteins in combination with a compound that inhibits autophagy.
    Type: Application
    Filed: October 3, 2018
    Publication date: July 23, 2020
    Inventors: CHARLES J. BIEBERICH, XIANG LI
  • PIM KINASE INHIBITORS IN COMBINATION WITH RNA SPLICING MODULATORS/INHIBITORS FOR TREATMENT OF CANCERS
    Publication number: 20200046689
    Abstract: The present invention provides for a method of treating cancer and/or reducing proliferation of cancer cells, the method comprising administering to a subject in need of such treatment a composition comprising a PIM kinase inhibitor that exhibits changes of mRNA splicing in combination with a compound that modulates/inhibits activity of an RNA splicing factor protein. Further, changes in splicing of mRNAs and phosphorylation of RNA splicing factors can be used as biomarkers for patient responsiveness to anti-PIM treatment and also suggest effective combinatorial therapies, including synergistic combination.
    Type: Application
    Filed: October 10, 2019
    Publication date: February 13, 2020
    Inventors: CHARLES J. BIEBERICH, XIANG LI, TEJASHREE JOGLEKAR
  • PIM kinase inhibitors in combination with RNA splicing modulators/inhibitors for treatment of cancers
    Patent number: 10525047
    Abstract: The present invention provides for a method of treating cancer and/or reducing proliferation of cancer cells, the method comprising administering to a subject in need of such treatment a composition comprising a PIM kinase inhibitor that exhibits changes of mRNA splicing in combination with a compound that modulates/inhibits activity of an RNA splicing factor protein. Further, changes in splicing of mRNAs and phosphorylation of RNA splicing factors can be used as biomarkers for patient responsiveness to anti-PIM treatment and also suggest effective combinatorial therapies, including synergistic combination.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: January 7, 2020
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Charles J. Bieberich, Xiang Li, Tejashree Joglekar
  • PIM KINASE INHIBITORS IN COMBINATION WITH RNA SPLICING MODULATORS/INHIBITORS FOR TREATMENT OF CANCERS
    Publication number: 20190076416
    Abstract: The present invention provides for a method of treating cancer and/or reducing proliferation of cancer cells, the method comprising administering to a subject in need of such treatment a composition comprising a PIM kinase inhibitor that exhibits changes of mRNA splicing in combination with a compound that modulates/inhibits activity of an RNA splicing factor protein. Further, changes in splicing of mRNAs and phosphorylation of RNA splicing factors can be used as biomarkers for patient responsiveness to anti-PIM treatment and also suggest effective combinatorial therapies, including synergistic combination.
    Type: Application
    Filed: March 22, 2017
    Publication date: March 14, 2019
    Inventors: CHARLES J. BIEBERICH, XIANG LI, TEJASHREE JOGLEKAR