Patents by Inventor Charles J. Nichols

Charles J. Nichols has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C-terminus modified heptapeptide LHRH analogs
    Patent number: 6191115
    Abstract: The present invention relates to a class of heptapeptide analogs of LHRH. These compounds are useful in the treatment of disease conditions which are mediated by reproductive hormones, including benign prostate hyperplasia, prostate tumors, breast and ovaries tumors, cryptorchidism, hirsuitism, gastric motility disorders, dysmenorrhea, and endometriosis.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: February 20, 2001
    Assignee: Abbott Laboratories
    Inventors: Fortuna Haviv, Wesley J. Dwight, Charles J. Nichols, Jonathan Greer
  • Macrolide LHRH antagonists
    Patent number: 6020521
    Abstract: Disclosed are 3'-N-desmethyl-3'-N-susbstituted-6-O-methyl-11-deoxy-11,12-cyclic carbamate erythrolide A derivatives which are antagonists of luteinizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.
    Type: Grant
    Filed: August 26, 1998
    Date of Patent: February 1, 2000
    Assignee: Abbott Laboratories
    Inventors: John T. Randolph, Fortuna Haviv, Daryl Sauer, Philip Waid, Charles J. Nichols, Nicholas A. Mort, Christopher R. Dalton, Jonathan Greer
  • 6-position modified decapeptide LHRH antagonists
    Patent number: 5698522
    Abstract: The present invention provides a class of decapeptide compounds which are potent antagonists of LHRH activity and which have the structure A.sup.1 -D.sup.2 -E.sup.3 -G.sup.4 -J.sup.5 -L.sup.6 -M.sup.7 -Q.sup.8 -R.sup.9 -T.sup.10. The compounds of the percent invention are characterized by having an .OMEGA.-amino-functionalized side chain on the D-aminoacyl residue at position 6. The .OMEGA.-amino group of this side chain is further derivatized by the attachment of an extending group which likewise has a terminal amino group which is capped by an acyl group.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: December 16, 1997
    Assignee: Abbott Laboratories
    Inventors: Fortuna Haviv, Timothy D. Fitzpatrick, Rolf E. Swenson, Charles J. Nichols, Nicholas A. Mort, Jonathan Greer
  • N-terminus modified analogs of LHRH
    Patent number: 5502035
    Abstract: Decapaptide and undecapaptides substituted on the N-terminal nitrogen atom by acyl groups which include furo-2-yl, isonicotinyl, nicotinyl, 2-, 3-, and 4-quinolinecarbonyl, shikimyl, dihydroshikimyl, and tetrahydrofur-2-oyl are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.
    Type: Grant
    Filed: July 27, 1994
    Date of Patent: March 26, 1996
    Assignee: Tap Holdings Inc.
    Inventors: Fortuna Haviv, Timothy D. Fitzpatrick, Rolf E. Swenson, Charles J. Nichols, Nicholas A. Mort
  • N-terminus modified analogs of LHRH
    Patent number: 5413990
    Abstract: Decapaptides substituted on the N-terminal nitrogen atom by acyl groups are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.
    Type: Grant
    Filed: August 6, 1993
    Date of Patent: May 9, 1995
    Assignee: Tap Pharmaceuticals Inc.
    Inventors: Fortuna Haviv, Timothy D. Fitzpatrick, Rolf E. Swenson, Charles J. Nichols, Nicholas A. Mort