Abstract: A miniaturized obstruction treatment device, e.g., a resilient brush, particularly adapted for medical use formed at the distal end of an elongated brush drive shaft having a hollow lumen formed therein for introduction over a guidewire. The brush drive shaft is enclosed in the lumen of a brush delivery catheter, and the brush is adapted to be garaged in a distal end section of the brush delivery catheter lumen. A Y-connector and a brush sub-assembly connector are attached to the proximal end of the brush delivery catheter and form a brush sub-assembly with the brush drive shaft and brush. The Y-connector allows infusion of thrombolytic agents into the brush delivery catheter lumen for emission at the distal end opening thereof adjacent the brush. In use, the brush sub-assembly connector connects the brush sub-assembly with a drive motor unit connector of a drive motor unit. The drive motor unit receives the proximal end of the drive shaft and rotates it to rotate the brush bristles.