Patents by Inventor Charles K. Marlowe

Charles K. Marlowe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ketoheterocyclic inhibitors of factor Xa
    Patent number: 6211154
    Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 3, 2001
    Assignee: COR Therapeutics, Inc.
    Inventors: Robert M. Scarborough, Charles K. Marlowe, Bing-Yan Zhu
  • Ketoheterocyclic inhibitors of factor Xa
    Patent number: 6197748
    Abstract: Ketoheterocyclic compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are usefull in vitro or in vivo for preventing or treating coagulation disorders.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: March 6, 2001
    Assignee: COR Therapeutics, Inc.
    Inventors: Robert M. Scarborough, Charles K. Marlowe, Bing-Yan Zhu
  • Ketoheterocyclic inhibitors of factor Xa
    Patent number: 6069130
    Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 30, 2000
    Assignee: COR Therapeutics, Inc.
    Inventors: Robert M. Scarborough, Charles K. Marlowe, Bing-Yan Zhu
  • Inhibitors of factor XA
    Patent number: 6046169
    Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 4, 2000
    Assignee: COR Therapeutics, Inc.
    Inventors: Charles K. Marlowe, Robert M. Scarborough, Alan M. Laibelman, Uma Sinha, Bing-Yan Zhu
  • Ketoheterocyclic inhibitors of factor Xa
    Patent number: 6022861
    Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 8, 2000
    Assignee: COR Therapeutics, Inc.
    Inventors: Robert M. Scarborough, Charles K. Marlowe, Bing-Yan Zhu
  • Inhibitors of factor XA
    Patent number: 5919765
    Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 6, 1999
    Assignee: COR Therapeutics, Inc.
    Inventors: Charles K. Marlowe, Robert M. Scarborough, Alan M. Laibelman, Uma Sinha, Bing-Yan Zhu
  • Synthesis of N-substituted oligomers
    Patent number: 5877278
    Abstract: A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two "sub-monomers" directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by --NH.sub.2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound .alpha.-haloacetamide) with a sufficient amount of a second sub-monomer comprising an --NH.sub.2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 2, 1999
    Assignee: Chiron Corporation
    Inventors: Ronald N. Zuckermann, Dane A. Goff, Simon Ng, Kerry Spear, Barbara O. Scott, Aaron C. Sigmund, Richard A. Goldsmith, Charles K. Marlowe, Yazhong Pei, Lutz Richter, Reyna Simon
  • Inhibitors of factor Xa
    Patent number: 5721214
    Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 24, 1998
    Assignee: COR Therapeutics, Inc.
    Inventors: Charles K. Marlowe, Robert M. Scarborough, Alan M. Laibelman, Uma Sinha, Bing-Yan Zhu