Abstract: A multi-temporal, multi-angle, automated target exploitation method is provided for processing a large number of images. The system geo-rectifies the images to a three-dimensional surface topography, co-registers groups of the images with fractional pixel accuracy, automates change detection, evaluates the significance of change between the images, and massively compresses imagery sets based on the statistical significance of change. The method improves the resolution, accuracy, and quality of information extracted beyond the capabilities of any single image, and creates registered six-dimensional image datasets appropriate for mathematical treatment using standard multi-variable analysis techniques from vector calculus and linear algebra such as time-series analysis and eigenvector decomposition.