Patents by Inventor Charles M. Cohen

Charles M. Cohen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing human epidermal growth factor and analogs thereof
    Patent number: 4743679
    Abstract: Disclosed is a process for producing a fusion protein comprising epidermal growth factor (EGF) attached through a Glu-residue to a leader. Treatment of the fusion protein with a Staphylococcus aureus V8 protease specific for cleaving peptides at a Glu-linkage produces large amounts of the 53 amino acid EGF sequence.The treatment conditions optimize production of the 53 and 51 amino acid EGFs relative to shorter analogs, and take full advantage of the selectivity of the protease.
    Type: Grant
    Filed: February 24, 1986
    Date of Patent: May 10, 1988
    Assignee: Creative Biomolecules, Inc.
    Inventors: Charles M. Cohen, Roberto Crea