Abstract: A method for treating an infection comprises administering a peptide in synergistic combination with an antibiotic, wherein the peptide comprises an amino acid sequence with a formula selected from the group consisting of: (a) Bn1-Z; (b) Bn1-Z-Bn2; and (c) Z-Bn1 wherein B is a basic amino acid residue; n1 and n2 are 1 to 6; and Z is a sequence of from about 7 to about 24 amino acid residues, said sequence having an average hydrophobicity value of at least 0.3 on the Liu-Deber scale.

Abstract: A method for treating an infection comprises administering a peptide in synergistic combination with an antibiotic, wherein the peptide comprises an amino acid sequence with a formula selected from the group consisting of: Bn1-Z;??(a) Bn1-Z-Bn2; and??(b) Z-Bn1??(c) wherein B is a basic amino acid residue; n1 and n2 are 1 to 6; and Z is a sequence of from about 7 to about 24 amino acid residues, said sequence having an average hydrophobicity value of at least 0.3 on the Liu-Deber scale.

Abstract: A peptide comprises the sequence: X1-X2-(G or S)-X3-X4-L-(I or M)-X5-X6-G-(V or I)-X7X8 wherein each of X1-X8 is independently any amino acid and is independently present or absent; wherein the peptide has fewer than 30 amino acid residues; and wherein the peptide binds to and inhibits an efflux pump, with the proviso that the peptide does not comprise VVGLALIVAGVVV or VVGLALINAGVVV

Abstract: A method for treating an infection comprises administering a peptide in synergistic combination with an antibiotic, wherein the peptide comprises an amino acid sequence with a formula selected from the group consisting of: Bn1-Z;??(a) Bn1-Z-Bn2; and??(b) Z-Bn1??(c) wherein B is a basic amino acid residue; n1 and n2 are 1 to 6; and Z is a sequence of from about 7 to about 24 amino acid residues, said sequence having an average hydrophobicity value of at least 0.3 on the Liu-Deber scale.

Abstract: A method is described for treating a microbial infection with a peptide whose amino acid sequence has a formula selected from the group consisting of: (a) Bn1?Z; (b) Bn1?Z?Bn2; and (c) Z?Bn1 wherein B is a basic amino acid residue; n1 and n2 are 1 to 6; and Z is a sequence of about 11 to about 24 amino acid residues, the sequence having an average hydrophobicity value of at least 0.3, and preferably at least 0.4. These peptides show antimicrobial activity against microorganisms including both Gram-positive and Gram-negative bacteria.

Abstract: A method is described for treating a microbial infection with a peptide whose amino acid sequence has a formula selected from the group consisting of:

Abstract: Halo-A-23187 derivatives, prepared by reaction of antibiotic A-23187 with an N-halo-type halogenating agent, and salts thereof, which are (1) useful biochemical tools for the study of transport of ions in cellular systems, (2) useful chemical tools for removal and recovery of ions, and (3) potential cardiotonic agents.