Patents by Inventor Charles M. McGrath
Charles M. McGrath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11366061Abstract: An approach is described that combines distinct properties of a specialized porous nitrocellulose film (PNC) with quantum nanoparticles to create an improved assay and detection sensitivity, permitting the development of a camera-based imaging system for fluorescent detection of macromolecules in microarray format. The two properties of PNC that facilitate the approach are an extraordinarily high binding capacity and a newly observed internal scattering of light. Quantum nanoparticles complement these PNC properties by providing a higher level of emitted light than the fluorescent dyes in common microarray use. Overall, the approach allows for instrument cost savings, reduced imaging time, and the ability to remotely image.Type: GrantFiled: January 23, 2014Date of Patent: June 21, 2022Assignee: Grace Bio-Labs, Inc.Inventors: Jennipher Lyn Grudzien, Michael Albert Shultz, Florian Gene Bell, Charles M. McGrath
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Publication number: 20140206580Abstract: An approach is described that combines distinct properties of a specialized porous nitrocellulose film (PNC) with quantum nanoparticles to create an improved assay and detection sensitivity, permitting the development of a camera-based imaging system for fluorescent detection of macromolecules in microarray format. The two properties of PNC that facilitate the approach are an extraordinarily high binding capacity and a newly observed internal scattering of light. Quantum nanoparticles complement these PNC properties by providing a higher level of emitted light than the fluorescent dyes in common microarray use. Overall, the approach allows for instrument cost savings, reduced imaging time, and the ability to remotely image.Type: ApplicationFiled: January 23, 2014Publication date: July 24, 2014Applicant: Grace Bio-Labs, Inc.Inventors: Jennipher Lyn Grudzien, Michael Albert Shultz, Florian Gene Bell, Charles M. McGrath
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Patent number: 8287822Abstract: A reaction surface array diagnostic apparatus and method of making the same includes a substrate carrying a plurality of reaction surfaces, a plate and a gasket, each having a plurality of through bores, alignable with one of the reaction surfaces and forming a fluid tight well about each reaction surface when the gasket and the plate are sealingly affixed to the substrate to form a stack. Clamp members engage opposite side edges of a stack to compress the gasket. A plurality of side-by-side disposed clamped stacks of plates, gaskets and substrates are mounted in a tray in the standard footprint of a microtitre plate. Alternately, the plate and the gasket are combined into a single plate formed of a flexible material having an adhesive on one surface.Type: GrantFiled: May 14, 2010Date of Patent: October 16, 2012Assignee: Grace Bio-Labs, Inc.Inventors: Jennipher Grudzien, Charles M. McGrath
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Publication number: 20100267590Abstract: A reaction surface array diagnostic apparatus and method of making the same includes a substrate carrying a plurality of reaction surfaces, a plate and a gasket, each having a plurality of through bores, alignable with one of the reaction surfaces and forming a fluid tight well about each reaction surface when the gasket and the plate are sealingly affixed to the substrate to form a stack. Clamp members engage opposite side edges of a stack to compress the gasket. A plurality of side-by-side disposed clamped stacks of plates, gaskets and substrates are mounted in a tray in the standard footprint of a microtitre plate. Alternately, the plate and the gasket are combined into a single plate formed of a flexible material having an adhesive on one surface.Type: ApplicationFiled: May 14, 2010Publication date: October 21, 2010Applicant: GRACE BIO-LABS, INC.Inventors: Jennipher Grudzien, Charles M. McGrath
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Patent number: 7731909Abstract: A reaction surface array diagnostic apparatus and method of making the same includes a substrate carrying a plurality of reaction surfaces, a plate and a gasket, each having a plurality of through bores, alignable with one of the reaction surfaces and forming a fluid tight well about each reaction surface when the gasket and the plate are sealingly affixed to the substrate to form a stack. Clamp members engage opposite side edges of a stack to compress the gasket. A plurality of side-by-side disposed clamped stacks of plates, gaskets and substrates are mounted in a tray in the standard footprint of a microtiter plate. Alternately, the plate and the gasket are combined into a single plate formed of a flexible material having an adhesive on one surface.Type: GrantFiled: February 20, 2004Date of Patent: June 8, 2010Assignee: Grace Bio-Labs, Inc.Inventors: Jennipher Grudzien, Charles M. McGrath
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Patent number: 5436152Abstract: Immortalized human epithelial cell sublines are provided. The novel cell lines do not undergo terminal differentiation and senescence upon exposure to high calcium concentrations. The novel cells exhibit positive reactivity with milk-fat globule membrane antigen and cytokeratin anti-serum. The cells are non-tumorigenic in athymic mice, and exhibit both three-dimensional growth in collagen and dome formation in confluent cultures. The cell sublines demonstrate growth control by hormones and growth factors. The novel cell sublines are useful in evaluating the capacity of preselected agents to bring about a change in epithelial cell growth and in the production of proteins.Type: GrantFiled: May 20, 1991Date of Patent: July 25, 1995Inventors: Herbert Soule, Charles M. McGrath
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Patent number: 5192503Abstract: A probe clip for in situ assay of tissue sections in the form of a plate having a first seal member mounted thereon and forming an interior cavity on the plate. In one embodiment, a second seal member is mounted interiorly of the first seal member and divides the interior cavity into first and second fluid communicatable surfaces, with a probe dryingly attached to the plate and disposed on the second mixing surface. The plate is joined to a slide carrying a tissue section and a reactant fluid such to form fluid communicatable reaction and mixing chambers. Successive rotations of the joined plate and slide causes the reactant fluid to initially flow to the mixing chamber and release the probe, before the probe flows to the reaction chamber for reaction with the tissue section. In another embodiment, a time-release material covers the probe mounted on a plate having a single chamber. The reactant fluid hydrolyzes the time-release material to release the probe for reaction with the tissue.Type: GrantFiled: May 23, 1990Date of Patent: March 9, 1993Inventors: Charles M. McGrath, Jennipher Grudzien
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Patent number: 5026637Abstract: Immortalized human epithelial cell sublines are provided. The novel cell lines do not undergo terminal differentiation and senescence upon exposure to high calcium concentrations. The novel cells exhibit positive reactivity with milk-fat globule membrane antigen and cytokeratin anti-serum. The cells are non-tumorigenic in athymic mice, and exhibit both three-dimensional growth in collagen and dome formation in confluent cultures. The cell sublines demonstrate growth control by hormones and growth factors. The novel cell sublines are useful in evaluating the capacity of preselected agents to bring about a change in epithelial cell growth and in the production of proteins.Type: GrantFiled: February 28, 1989Date of Patent: June 25, 1991Inventors: Herbert Soule, Charles M. McGrath