Patents by Inventor Charles P. Romano
Charles P. Romano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140194306Abstract: Expressed Sequence Tags (ESTs) isolated from the Western Corn Rootworm, Diabrotica virgifera virgifera LeConte, are disclosed. The invention encompasses nucleic acid molecules that encode D. v. virgifera protein homologs and fragments thereof. In addition, antibodies capable of binding the proteins are encompassed by the present invention. The disclosed ESTs have particular utility in isolating genes and promoters, identifying and mapping the genes involved in developmental and metabolic pathways, and determining gene function. The ESTs provide a unique molecular tool for the targeting and isolation of novel genes for plant protection and improvement. The invention also relates to methods of using the disclosed nucleic acid molecules, proteins, fragments of proteins, and antibodies, for example, for gene identification and analysis, and preparation of constructs.Type: ApplicationFiled: December 10, 2013Publication date: July 10, 2014Applicant: Monsanto Technology LLCInventors: Scott E. Andersen, Glenn R. Hicks, Joseph E. Huesing, Charles P. Romano, Clayton S. Vetsch
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Patent number: 8614370Abstract: Expressed Sequence Tags (ESTs) isolated from the Western Corn Rootworm, Diabrotica virgifera virgifera LeConte, are disclosed. The invention encompasses nucleic acid molecules that encode D. v. virgifera protein homologs and fragments thereof. In addition, antibodies capable of binding the proteins are encompassed by the present invention. The disclosed ESTs have particular utility in isolating genes and promoters, identifying and mapping the genes involved in developmental and metabolic pathways, and determining gene function. The ESTs provide a unique molecular tool for the targeting and isolation of novel genes for plant protection and improvement. The invention also relates to methods of using the disclosed nucleic acid molecules, proteins, fragments of proteins, and antibodies, for example, for gene identification and analysis, and preparation of constructs.Type: GrantFiled: October 27, 2009Date of Patent: December 24, 2013Assignee: Monsanto Technology LLCInventors: Scott E. Andersen, Glenn R. Hicks, Joseph E. Huesing, Charles P. Romano, Clayton S. Vetsch
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Patent number: 8344207Abstract: The present invention provides nucleotide sequences encoding an insecticidal protein exhibiting lepidopteran inhibitory activity, as well as a novel insecticidal protein referred to herein as a Cry1A.105 insecticide, transgenic plants expressing the insecticide, and methods for detecting the presence of the nucleotide sequences or the insecticide in a biological sample.Type: GrantFiled: May 23, 2011Date of Patent: January 1, 2013Assignee: Monsanto Technology LLCInventors: Natalia N. Bogdanova, David R. Corbin, Thomas M. Malvar, Frederick J. Perlak, James K. Roberts, Charles P. Romano
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Patent number: 8101826Abstract: The present invention discloses methods and compositions comprising a group of novel expression cassettes which provide significantly improved levels of accumulation of Coleopteran inhibitory Cry3B and Cry3B variant amino acid sequences when these are expressed in plants. The preferred embodiments of the invention provide at least up to ten fold higher levels of insect controlling protein relative to the highest levels obtained using prior compositions. In particular, transgenic maize expressing higher levels of a protein designed to exhibit increased toxicity toward Coleopteran pests deliver superior levels of insect protection and are less likely to sponsor development of populations of target insects that are resistant to the insecticidally active protein.Type: GrantFiled: March 30, 2010Date of Patent: January 24, 2012Assignee: Monsanto Technology LLCInventor: Charles P. Romano
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Publication number: 20110307978Abstract: The present invention provides nucleotide sequences encoding an insecticidal protein exhibiting lepidopteran inhibitory activity, as well as a novel insecticidal protein referred to herein as a Cry1A.105 insecticide, transgenic plants expressing the insecticide, and methods for detecting the presence of the nucleotide sequences or the insecticide in a biological sample.Type: ApplicationFiled: May 23, 2011Publication date: December 15, 2011Inventors: Natalia N. Bogdanova, David R. Corbin, Thomas M. Malvar, Frederick J. Perlak, James K. Roberts, Charles P. Romano
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Publication number: 20110277180Abstract: The present invention discloses methods and compositions comprising a group of novel expression cassettes which provide significantly improved levels of accumulation of Coleopteran inhibitory Cry3B and Cry3B variant amino acid sequences when these are expressed in plants. The preferred embodiments of the invention provide at least up to ten fold higher levels of insect controlling protein relative to the highest levels obtained using prior compositions. In particular, transgenic maize expressing higher levels of a protein designed to exhibit increased toxicity toward Coleopteran pests deliver superior levels of insect protection and are less likely to sponsor development of populations of target insects that are resistant to the insecticidally active protein.Type: ApplicationFiled: March 30, 2010Publication date: November 10, 2011Inventor: Charles P. Romano
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Patent number: 8034997Abstract: The present invention provides nucleotide sequences encoding an insecticidal protein exhibiting lepidopteran inhibitory activity, as well as a novel insecticidal protein referred to herein as a Cry1A.105 insecticide, transgenic plants expressing the insecticide, and methods for detecting the presence of the nucleotide sequences or the insecticide in a biological sample.Type: GrantFiled: August 30, 2006Date of Patent: October 11, 2011Assignee: Monsanto Technology LLCInventors: Natalia N. Bogdanova, David R. Corbin, Thomas M. Malvar, Frederick J. Perlak, James K. Roberts, Charles P. Romano
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Patent number: 8030542Abstract: Disclosed is a means of controlling plant pests by a novel method of expressing Cry2A B. thuringiensis ?-endotoxins in plants. The invention comprises novel nucleic acid segments encoding proteins comprising Cry2A B. thuringiensis ?-endotoxins. The nucleic acid segments are disclosed, as are transformation vectors containing the nucleic acid segments, plants transformed with the claimed segments, methods for transforming plants, and methods of controlling plant infestation by pests.Type: GrantFiled: April 19, 2010Date of Patent: October 4, 2011Assignee: Monsanto Technology LLCInventors: David R. Corbin, Charles P. Romano
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Publication number: 20110154545Abstract: Expressed Sequence Tags (ESTs) isolated from the Western Corn Rootworm, Diabrotica virgifera virgifera LeConte, are disclosed. The invention encompasses nucleic acid molecules that encode D. v. virgifera protein homologs and fragments thereof. In addition, antibodies capable of binding the proteins are encompassed by the present invention. The disclosed ESTs have particular utility in isolating genes and promoters, identifying and mapping the genes involved in developmental and metabolic pathways, and determining gene function. The ESTs provide a unique molecular tool for the targeting and isolation of novel genes for plant protection and improvement. The invention also relates to methods of using the disclosed nucleic acid molecules, proteins, fragments of proteins, and antibodies, for example, for gene identification and analysis, and preparation of constructs.Type: ApplicationFiled: October 27, 2009Publication date: June 23, 2011Inventors: Scott E. Andersen, Glenn R. Hicks, Joseph E. Huesing, Charles P. Romano, Clayton S. Vetsch
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Publication number: 20100319087Abstract: Disclosed is a means of controlling plant pests by a novel method of expressing Cry2A B. thuringiensis ?-endotoxins in plants. The invention comprises novel nucleic acid segments encoding proteins comprising Cry2A B. thuringiensis ?-endotoxins. The nucleic acid segments are disclosed, as are transformation vectors containing the nucleic acid segments, plants transformed with the claimed segments, methods for transforming plants, and methods of controlling plant infestation by pests.Type: ApplicationFiled: April 19, 2010Publication date: December 16, 2010Inventors: David R. Corbin, Charles P. Romano
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Publication number: 20100192265Abstract: Expressed Sequence Tags (ESTs) isolated from the Western Corn Rootworm, Diabrotica virgifera virgifera LeConte, are disclosed. The invention encompasses nucleic acid molecules that encode D. v. virgifera protein homologs and fragments thereof. In addition, antibodies capable of binding the proteins are encompassed by the present invention. The disclosed ESTs have particular utility in isolating genes and promoters, identifying and mapping the genes involved in developmental and metabolic pathways, and determining gene function. The ESTs provide a unique molecular tool for the targeting and isolation of novel genes for plant protection and improvement. The invention also relates to methods of using the disclosed nucleic acid molecules, proteins, fragments of proteins, and antibodies, for example, for gene identification and analysis, and preparation of constructs.Type: ApplicationFiled: October 27, 2009Publication date: July 29, 2010Inventors: Scott E. Andersen, Glenn R. Hicks, Joseph E. Huesing, Charles P. Romano, Clayton S. Vetsch
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Patent number: 7700830Abstract: Disclosed is a means of controlling plant pests by a novel method of expressing Cry2A B. thuringiensis ?-endotoxins in plants. The invention comprises novel nucleic acid segments encoding proteins comprising Cry2A B. thuringiensis ?-endotoxins. The nucleic acid segments are disclosed, as are transformation vectors containing the nucleic acid segments, plants transformed with the claimed segments, methods for transforming plants, and methods of controlling plant infestation by pests.Type: GrantFiled: November 10, 2005Date of Patent: April 20, 2010Assignee: Monsanto Technology LLCInventors: David R. Corbin, Charles P. Romano
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Patent number: 7612194Abstract: Expressed Sequence Tags (ESTs) isolated from the Western Corn Rootworm, Diabrotica virgifera virgifera LeConte, are disclosed. The invention encompasses nucleic acid molecules that encode D. v. virgifera protein homologs and fragments thereof. In addition, antibodies capable of binding the proteins are encompassed by the present invention. The disclosed ESTs have particular utility in isolating genes and promoters, identifying and mapping the genes involved in developmental and metabolic pathways, and determining gene function. The ESTs provide a unique molecular tool for the targeting and isolation of novel genes for plant protection and improvement. The invention also relates to methods of using the disclosed nucleic acid molecules, proteins, fragments of proteins, and antibodies, for example, for gene identification and analysis, and preparation of constructs.Type: GrantFiled: July 24, 2002Date of Patent: November 3, 2009Assignee: Monsanto Technology LLCInventors: Scott E. Andersen, Glenn R. Hicks, Joseph E. Huesing, Charles P. Romano, Clayton S. Vetsch
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Publication number: 20090238798Abstract: The present invention provides nucleotide sequences encoding an insecticidal protein exhibiting lepidopteran inhibitory activity, as well as a novel insecticidal protein referred to herein as a Cry1A.105 insecticide, transgenic plants expressing the insecticide, and methods for detecting the presence of the nucleotide sequences or the insecticide in a biological sample.Type: ApplicationFiled: August 30, 2006Publication date: September 24, 2009Inventors: Natalia N. Bogdanova, David R. Corbin, Thomas M. Malvar, Frederick J. Perlak, James K. Roberts, Charles P. Romano
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Publication number: 20090019609Abstract: The present invention discloses methods and compositions comprising a group of novel expression cassettes which provide significantly improved levels of accumulation of Coleopteran inhibitory Cry3B and Cry3B variant amino acid sequences when these are expressed in plants. The preferred embodiments of the invention provide at least up to ten fold higher levels of insect controlling protein relative to the highest levels obtained using prior compositions. In particular, transgenic maize expressing higher levels of a protein designed to exhibit increased toxicity toward Coleopteran pests deliver superior levels of insect protection and are less likely to sponsor development of populations of target insects that are resistant to the insecticidally active protein.Type: ApplicationFiled: August 1, 2008Publication date: January 15, 2009Inventor: Charles P. Romano
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Patent number: 7408096Abstract: The present invention discloses methods and compositions comprising a novel expression cassette providing significantly improved levels of accumulation of Coleopteran inhibitory Cry3B variant protein when expressed in maize plants. The preferred embodiments of the invention provide at least up to ten fold higher levels of insect controlling protein relative to the highest levels obtained using prior compositions. In particular, transgenic maize expressing higher levels of a protein designed to exhibit increased toxicity toward Coleopteran pests deliver superior levels of insect protection and are less likely to sponsor development of populations of target insects that are resistant to the insecticidally active protein.Type: GrantFiled: July 29, 2005Date of Patent: August 5, 2008Assignee: Monsanto Technology LLCInventor: Charles P. Romano
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Patent number: 7064249Abstract: Disclosed is a means of controlling plant pests by a novel method of expressing Cry2A B. thuringiensis ?-endotoxins in plants. The invention comprises novel nucleic acid segments encoding proteins comprising Cry2A B. thuringiensis ?-endotoxins. The nucleic acid segments are disclosed, as are transformation vectors containing the nucleic acid segments, plants transformed with the claimed segments, methods for transforming plants, and methods of controlling plant infestation by pests.Type: GrantFiled: July 18, 2002Date of Patent: June 20, 2006Assignee: Monsanto Technology LLCInventors: David R. Corbin, Charles P. Romano
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Patent number: 6943281Abstract: The present invention discloses methods and compositions comprising a group of novel expression cassettes which provide significantly improved levels of accumulation of Coleopteran inhibitory Cry3B and Cry3B variant amino acid sequences when these are expressed in plants. The preferred embodiments of the invention provide at least up to ten fold higher levels of insect controlling protein relative to the highest levels obtained using prior compositions. In particular, transgenic maize expressing higher levels of a protein designed to exhibit increased toxicity toward Coleopteran pests deliver superior levels of insect protection and are less likely to sponsor development of populations of target insects that are resistant to the insecticidally active protein.Type: GrantFiled: August 29, 2002Date of Patent: September 13, 2005Assignee: Monsanto Technology LLCInventor: Charles P. Romano
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Patent number: 6750009Abstract: Methods and compositions are provided for screening candidate antiviral agents using cells containing subgenomic viral replication systems such as replicons and minigenomes. The methods involve the simultaneous assay of more than one subgenomic viral replication system. Compositions useful for these methods are also provided.Type: GrantFiled: January 29, 2002Date of Patent: June 15, 2004Assignee: Apath, LLCInventors: Julie Dyall, Charles P. Romano, Paul D. Olivo, Robert M. Roth
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Publication number: 20030188336Abstract: Disclosed is a means of controlling plant pests by a novel method of expressing Cry2A B. thuringiensis &dgr;-endotoxins in plants. The invention comprises novel nucleic acid segments encoding proteins comprising Cry2A B. thuringiensis &dgr;-endotoxins. The nucleic acid segments are disclosed, as are transformation vectors containing the nucleic acid segments, plants transformed with the claimed segments, methods for transforming plants, and methods of controlling plant infestation by pests.Type: ApplicationFiled: July 18, 2002Publication date: October 2, 2003Inventors: David R. Corbin, Charles P. Romano