Abstract: Disclosed herein are methods and compositions for associating a genetic variant with intraretinal fluid. Also disclosed herein are methods and compositions for associating a genetic variant with visual acuity, anatomic outcomes or treatment frequency.

Abstract: The present disclosure provides methods of avoiding arthritic side effects of pain treatments, in particular, the side effects of osteoarthritis (OA) pain treatments, through identification of subjects who are likely to suffer the pain treatment related side effects.

Abstract: Disclosed herein are methods and compositions for associating a genetic variant with intraretinal fluid. Also disclosed herein are methods and compositions for associating a genetic variant with visual acuity, anatomic outcomes or treatment frequency.

Abstract: The present disclosure provides methods of treating lung disease subjects that are likely to respond to an IL-33 antagonist, an interleukin-4 receptor alpha antagonist, or an IL-13 receptor antagonist, based on the subject's IL-33 Asthma polygenic risk score.

Abstract: The present disclosure provides methods of identifying subjects having a lung disease or at risk of developing a lung disease that will respond favorably to treatment with a therapeutic agent that treats or inhibits a lung disease, such as dupilumab, an inhaled corticosteroid (ICS), or a long-acting beta agonist (LABA), and methods of treating a subject having a lung disease with a therapeutic agent that treats or inhibits a lung disease, such as dupilumab, an ICS, or a LABA, and determining or having determined the subject's FEV1 polygenic score (FEV1-PS).

Abstract: The present disclosure provides methods of identifying subjects having a risk of developing asthma exacerbation and methods of treating subjects having asthma and who are undergoing or will be undergoing treatment with an IL4R alpha antagonist and/or the IL13 blocking agent.

Abstract: Disclosed herein are methods and compositions for associating a genetic variant with intraretinal fluid. Also disclosed herein are methods and compositions for associating a genetic variant with visual acuity, anatomic outcomes or treatment frequency.

Abstract: The present disclosure provides methods of treating subjects having sepsis, SIRS, septic shock, and/or MODS, methods of identifying subjects having an increased risk of developing sepsis, SIRS, septic shock, and/or MODS, and methods of detecting Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and/or Low Density Lipoprotein Receptor (LDLR) variant nucleic acid molecules and variant polypeptides.

Abstract: The present disclosure provides methods of reducing cardiovascular risk by administration of a PCSK9 inhibitor to patients having a genetic profile associated with response to PCSK9 inhibitor therapy.

Abstract: The invention is directed to the use of biomarkers to determine responsiveness of an individual with Fragile X Syndrome (FXS) to treatment with an mGluR5 antagonist.

Abstract: This disclosure relates to a method of determining the presence of at least one HLA allele, preferably selected from the group consisting of DQA1*0102, DRB1*1501, DQB1*0602 and DRB5*0101 to assess whether a patient is at risk for developing hepatotoxicity upon administration of the COX-2 inhibitor lumiracoxib. Also disclosed is the use of a kit for carrying out this method. The disclosure also relates to a method of treating cyclooxygenase-2 dependent disorders with lumiracoxib in a subject that is not a carrier of one or more HLA alleles, preferably selected from the group consisting of DQA1*0102, DRB1*1501, DQB1*0602 and DRB5*0101.

Abstract: The invention relates to a newly identified tumor suppressor gene, designated DOS (for Deleted in Osteosarcoma and alternatively referred to herein as DOCK 3) which has been cloned from human and mouse cells. The DOS nucleic acid and protein molecules and their use in the diagnosing and treating disorders characterized by aberrant DOS molecule expression are described.