Abstract: A system and method for heart rhythm detection and reporting are disclosed. This cardiology system includes a biosensor system and a data analysis system. The biosensor system is worn by an individual and includes sensors that detect biosignals including infrasonic signals from the individual. The data analysis system receives the biosignals from the biosensor system, and determines heart rhythms of the individual based upon the biosignals. The system identifies at least some of biosignals as being associated with cardiovascular activity, such as pulse wave signals. Preferably, the biosensor system is an in-ear biosensor system that detects the biosignals via left and right earbuds placed within or at ear canals of the individual. The system can also identify arrhythmias including atrial fibrillation (Afib) arrhythmias from the heart rhythms, report information to health care and safety professionals and update medical records of the individuals.

Abstract: A system and method for cardiovascular monitoring and reporting are disclosed. The system (CV monitoring system) includes a data analysis system and an in-ear biosensor system that preferably includes left and right earbuds. The earbuds include infrasound/vibration sensors that detect biosignals from the individual including signals associated with cardiovascular activity (CV signals). The analysis system calculates cardiovascular function measurements (CV function measurements) based upon the CV signals. The CV monitoring system uses machine learning to predict blood pressure (BP) measurements of the individual based upon the CV signals and the calculated CV function measurements. In an embodiment, the CV monitoring system includes an EKG detection system that detects EKG signals associated with heart function.

Abstract: A system and method for cardiovascular monitoring and reporting are disclosed. The system (CV monitoring system) includes a data analysis system and an in-ear biosensor system that preferably includes left and right earbuds. The earbuds include infrasound/vibration sensors that detect biosignals from the individual including signals associated with cardiovascular activity (CV signals). The analysis system calculates cardiovascular function measurements (CV function measurements) based upon the CV signals. The CV monitoring system uses machine learning to predict blood pressure (BP) measurements of the individual based upon the CV signals and the calculated CV function measurements. In an embodiment, the CV monitoring system includes an EKG detection system that detects EKG signals associated with heart function.

Abstract: An exemplary method is disclosed that can be used in the diagnosis of hypertrophic cardiomyopathy (HCM) using a biophysical-sensor system configured to non-invasively and concurrently acquire electrocardiographic signals, seismographic signals, photoplethysmographic, and/or phonocardiographic signals, collectively referred to herein as biophysical signals, from at least the thoracic region of a subject. The acquired biophysical signals may be assessed for one or more conditions or indicators of hypertrophic cardiomyopathy and concurrently with other cardiac diseases, conditions, or indicators of either.

Abstract: Provided herein are compositions that includes AAVs and AAV vectors that include a sequence encoding a SARS-CoV-2 polypeptide or a fragment thereof. Also provided herein are methods and materials for making and using AAVs and AAV vectors to generate immunity to a coronavirus in a subject.

Abstract: A system and method for cardiovascular monitoring and reporting are disclosed. The system (CV monitoring system) includes a data analysis system and an in-ear biosensor system that preferably includes left and right earbuds. The earbuds include infrasound/vibration sensors that detect biosignals from the individual including signals associated with cardiovascular activity (CV signals). The analysis system calculates cardiovascular function measurements (CV function measurements) based upon the CV signals. The CV monitoring system uses machine learning to predict blood pressure (BP) measurements of the individual based upon the CV signals and the calculated CV function measurements. In an embodiment, the CV monitoring system includes an EKG detection system that detects EKG signals associated with heart function.

Abstract: A system and method for heart rhythm detection and reporting are disclosed. This cardiology system includes a biosensor system and a data analysis system. The biosensor system is worn by an individual and includes sensors that detect biosignals including infrasonic signals from the individual. The data analysis system receives the biosignals from the biosensor system, and determines heart rhythms of the individual based upon the biosignals. The system identifies at least some of biosignals as being associated with cardiovascular activity, such as pulse wave signals. Preferably, the biosensor system is an in-ear biosensor system that detects the biosignals via left and right earbuds placed within or at ear canals of the individual. The system can also identify arrhythmias including atrial fibrillation (Afib) arrhythmias from the heart rhythms, report information to health care and safety professionals and update medical records of the individuals.

Abstract: A device (100) for supporting a valve annulus is described that includes spaced apart support members (105) and a connecting member (110) extending between and connecting the support members. At least one adjustor (115) is also provided that is engaged with the connecting member and can be actuated to modify a length of the connecting member between two adjacent support members. In addition, each support member may include at least two channels extending through the support members at different heights with respect to an overall thickness of the respective support member. Each channel may receive a portion of the connecting member therethrough, and each support member may further include a passageway between the channels to allow selection of one of the channels. In this way, the device may be adjusted in at least two dimensions to support the valve leaflets and promote sufficient closure of the leaflets.

Abstract: Systems and methods for regulating fluid volume from an isolated cardiac circuit during cardiopulmonary bypass surgery are described. In one embodiment, a system in accordance with the present technology can include a pressure-regulated volume control unit configured to regulate a cardiac circuit volume based on a measured return pressure detected at an outflow from an internal heart portion of cardiac circuit. The system can also include a first pressure sensor configured to detect the measured return pressure.

Abstract: A device (100) for supporting a valve annulus is described that includes spaced apart support members (105) and a connecting member (110) extending between and connecting the support members. At least one adjustor (115) is also provided that is engaged with the connecting member and can be actuated to modify a length of the connecting member between two adjacent support members. In addition, each support member may include at least two channels extending through the support members at different heights with respect to an overall thickness of the respective support member. Each channel may receive a portion of the connecting member therethrough, and each support member may further include a passageway between the channels to allow selection of one of the channels. In this way, the device may be adjusted in at least two dimensions to support the valve leaflets and promote sufficient closure of the leaflets.

Abstract: A vaginal laxity/uterine prolapse system is disclosed. The system includes vaginal laxity/uterine prolapse device and a suction device. The vaginal laxity/uterine prolapse device includes a shaft sized and configured for insertion into a patient's vagina. The shaft includes a plurality of suction ports. The shaft is coupled to a suction device to generate suction through the plurality of suction ports. The suction causes edema and increased blood flow to the vagina walls, resulting in an immediate increase in vaginal tone (“tightness”) and over time, with repeated use, causes hypertrophy of the vaginal wall and associated pelvic musculature, resulting in a permanent increase in vaginal tightness, significantly increasing the friction resistance to penile penetration.

Abstract: A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the full length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex.

Abstract: A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the full length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex.

Abstract: A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the full length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex.

Abstract: A perfusion circuit and a use thereof for delivering a substance to a subject's heart in situ during cardiopulmonary bypass surgery are provided. The perfusion circuit defines a path for re-circulating a solution containing a macromolecular complex through a coronary circulation circuit through a subject's heart during a surgical procedure in which the substance is prevented from being delivered to the subject's other organs.

Abstract: A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the full length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex.

Abstract: A method of delivering cardiac stem cell and treating damaged cardiac tissue is provided. The method involves isolation of subject's cardiac circulation from the subject's systemic circulation and perfusing a solution comprising stem cells into the cardiac circuit.

Abstract: A perfusion circuit and a use thereof for delivering a substance to a subject's heart in situ during cardiopulmonary bypass surgery are provided. The perfusion circuit defines a path for re-circulating a solution containing a macromolecular complex through a coronary circulation circuit through a subject's heart during a surgical procedure in which the substance is prevented from being delivered to the subject's other organs.

Abstract: A method for transferring a macromolecular complex to muscle cells by exsanguinating a region of the subject's microvasculature and delivering the complex to this region under high hydrostatic pressure. A balloon catheter having a balloon that extends substantially the full length of the cannula that is inserted into the subject is provided for use in the systemic delivery of macromolecular complex.

Abstract: A method of delivering cardiac stem cell and treating damaged cardiac tissue is provided. The method involves isolation of subject's cardiac circulation from the subject's systemic circulation and perfusing a solution comprising stem cells into the cardiac circuit.