Patents by Inventor Charles Riggin

Charles Riggin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for purifying recombinant proteins, and products thereof
    Patent number: 4734362
    Abstract: The present invention relates to a process for recovering recombinant protein from refractile inclusion bodies of microorganisms which comprise disrupting cells, recovering refractile bodies containing recombinant protein, solubilizing the refractile bodies with a denaturant, protecting sulfhydryl groups of recombinant proteins, converting cationic amino groups of recombinant proteins to anionic carboxylic acid by derivatization with organic cyclic acid anhydrides, and recovering recombinant protein derivatives.The present invention also relates to the production of solid supports coated with recombinant protein recovered by the process of the invention, and the use of said devices for the detection and quantification of antibodies to said recombinant proteins in body fluids.
    Type: Grant
    Filed: September 25, 1986
    Date of Patent: March 29, 1988
    Assignee: Cambridge Bioscience Corporation
    Inventors: Chung-Ho Hung, Richard Thorn, Charles Riggin, Dante Marciani