Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

Abstract: Systems, methods, and apparatuses for generating and using machine learning models using genetic data. A set of input features for training the machine learning model can be identified and used to train the model based on training samples, e.g., for which one or more labels are known. As examples, the input features can include aligned variables (e.g., derived from sequences aligned to a population level or individual references) and/or non-aligned variables (e.g., sequence content). The features can be classified into different groups based on the underlying genetic data or intermediate values resulting from a processing of the underlying genetic data. Features can be selected from a feature space for creating a feature vector for training a model. The selection and creation of feature vectors can be performed iteratively to train many models as part of a search for optimal features and an optimal model.

Abstract: The present invention relates generally to methods and materials for treating synaptopathies, based on the use of Leu-co-methylthioninium acid salts, which are disclosed herein to increase synaptophysin levels in various brain regions at therapeutically relevant doses both in animal models of neurodegenerative disease, and in normal animals.

Abstract: A volume of natural gas including a volume of methane and a volume of other alkanes may be cleaned of the other alkanes using a steam reformer system to create synthesis gas.

Abstract: The present invention relates generally to nootropic compositions comprising Leuco-methylthioninium acid salts and their uses for cognitive enhancement in normal (non-demented) individuals.

Abstract: A system comprises a slave cylinder for a motorcycle. The slave cylinder may include a rod with a height which is hydraulically adjustable by a hydraulic pressure adjuster. A motorcycle slave cylinder is also provided which includes a rod having a height. The motorcycle slave cylinder also includes a hydraulic pressure adjuster. The hydraulic pressure adjuster hydraulically adjusts the height of the rod above the motorcycle slave cylinder.

Abstract: One variation of a method for manipulating virtual objects within a virtual environment includes: determining a first position of a touch sensor within real space; based on the first position of the touch sensor within real space, bounding a virtual surface of a virtual object within the virtual environment tractable through inputs across the touch sensor; generating a first force vector comprising a magnitude related to a force magnitude of a first input on the touch sensor surface and a direction related to an orientation of the touch sensor within real space; locating an origin of the first force vector within the virtual environment based on a first location of the first input on the touch sensor surface and the first position of the touch sensor within real space; and manipulating the virtual surface of the virtual object within the virtual environment according to the first force vector.

Abstract: A computer includes a processor and a memory storing instructions executable by the processor to determine a predicted classification related to a road segment; upon a vehicle including the computer traveling over the road segment, determine an actual classification related to the road segment; in response to the actual classification failing to match the predicted classification, transmit a notification to a server remote from the vehicle; and upon receiving an instruction responsive to the notification, transmit vehicle data related to the road segment to the server.

Abstract: Systems, methods, and computer-readable media provide techniques for on-demand access to object data hosted in distributed object storage. A query is received for the distributed object storage database, wherein the distributed object storage database includes first object data stored in a first data center at a first geographical location, and second object data stored in a second data center at a second geographical location. It is determined that the query is for at least a portion of the first object data stored by the first data center. The query is transmitted to a first computing device in the first data center. Results are received from the first computing device for the query, and the results are provided in response to the received query.

Abstract: A quick disconnect mount includes a mounting stud securable to a structure, and a connector securable on the mounting stud. The mounting stud includes at least one circumferential ridge and at least one circumferential trough, and the connector includes a central channel sized to fit over the mounting stud and a locking bar engageable with the circumferential trough.

Abstract: A gift bag with a pocket containing an integral pop-up structure which is operative to move between a first position wherein the pop-up structure is in a substantially flat position and substantially contained within the pocket of the gift bag, and a second position wherein the pop-up structure is unfolded into a three-dimensional structure that is substantially contained outside of the pocket of the gift bag.

Abstract: The technical description relates to mixed reality, augmented reality, and their use in the sharing of information about a procedure and in the performing of a procedure. A method for sharing information about a procedure and performing the procedure includes using a mixed reality system in a first location to display a mixed reality image having a virtual element representing information related to the procedure, instructing an information recipient to use an augmented reality system to view the virtual element, interacting with the virtual element to create a transformed virtual element, and manipulating a physical element in a second location while performing the procedure. Specific examples described herein relate to the field of medicine, and to orthopedics in particular.

Abstract: Disclosed herein is a composite comprising a metal alloy matrix; where the metal alloy matrix comprises aluminum in an amount greater than 50 atomic percent; a first metal and a second metal; where the first metal is different from the second metal; and where the metal alloy matrix comprises a low temperature melting phase and a high temperature melting phase; where the low temperature melting phase melts at a temperature that is lower than the high temperature melting phase; and a contracting constituent; where the contracting constituent exerts a compressive force on the metal alloy matrix at a temperature between a melting point of the low temperature melting phase and a melting point of the high temperature melting phase or below the melting points of the high and low temperature melting phases.

Abstract: A sending node may send a network message to a multicast IP address. The sending node and a recipient node may be in communication via a plurality of intermediary nodes. The recipient node may receive a number of copies of the network message that corresponds to a number of equal cost paths between the sending node and the recipient node. The recipient node may send a reply to each of the copies of the network message to the sending node. The sending node may provide the replies to a collector module, which may use the replies for network analytics, network monitoring, machine learning, and the like.

Abstract: An annular axial flux motor includes a rotor mounted on an annular subsection of a rotatable cam ring and a stator mounted on an annular subsection of a carrier frame. The rotor includes two Halbach arrays of permanent magnets spaced from each other on the cam ring along an axial direction. The stator includes multiple phase electrical windings printed on multiple layers of a printed circuit board (PCB) that are stacked along the axial direction. The multiple layers are positioned between the Halbach arrays, with active side of the Halbach arrays facing to opposite sides of the multiple layers. The Halbach arrays are configured to generate a symmetrical magnetic field and the multiple phase electrical windings are configured to have a same rotor-dependent torque constant, such that the stator can generate a constant torque to rotate the rotor and the cam ring within a finite travel range.

Abstract: A method of treating a subject having a disease caused by a pathogen, preferably an acid-labile pathogen, said method comprising the step of applying to the subject a therapeutically effect amount of a topical composition having biocidal properties or both pain-relieving and biocidal properties. The composition can be used to treat or control bacterial, viral, fungal or infestational pathogens, and related diseases. The disease can be foot and mouth disease (FMD) or scabby mouth (orf), caused by an acid-labile virus. The topical composition can be used to treat hoof rot/footrot/foot abscess and viral lesions.

Abstract: Disclosed herein is a composite comprising a metal alloy matrix; where the metal alloy matrix comprises aluminum in an amount greater than 50 atomic percent; a first metal and a second metal; where the first metal is different from the second metal; and where the metal alloy matrix comprises a low temperature melting phase and a high temperature melting phase; where the low temperature melting phase melts at a temperature that is lower than the high temperature melting phase; and a contracting constituent; where the contracting constituent exerts a compressive force on the metal alloy matrix at a temperature between a melting point of the low temperature melting phase and a melting point of the high temperature melting phase or below the melting points of the high and low temperature melting phases.

Abstract: An example head-mounted display device includes a light projector, an optical assembly arranged to direct light from a light projector to a user, and an actuator module. The optical assembly includes a variable focus lens assembly including a rigid refractive component, a shaper ring defining an aperture, and a flexible lens membrane between the shaper ring and the rigid refractive component and covering the aperture. The refractive component, the shaper ring, and the lens membrane are arranged along an axis. The refractive component and the lens membrane define a chamber containing a volume of fluid. The actuator module is configured to adjust an optical power of the variable focus lens by moving the shaper ring relative to the refractive component along the axis, such that a curvature of the lens membrane in the aperture is modified.

Abstract: A pain relieving aerosol spray (pain relieving and pain preventing aerosol spray) comprising a pain relieving composition and at least one refrigerant, wherein the pain relieving aerosol spray is capable of providing rapid onset local anaesthesia of intact skin and/or a wound of a subject to which it is applied and further pain relief due to the pain relieving composition remaining on the wound of the subject. The pain relieving composition comprises a liquid gel matrix that contains at least one anaesthetic agent, a vasoconstrictor, and an antiseptic agent. The spray can be used for a surgical procedure or animal husbandry procedure, such as castration or branding, or treating a burn or wound.

Abstract: A quick disconnect mount includes a mounting stud securable to a structure, and a connector securable on the mounting stud. The mounting stud includes at least one circumferential ridge and at least one circumferential trough, and the connector includes a central channel sized to fit over the mounting stud and a locking bar engageable with the circumferential trough.