Abstract: The present invention provides a method of treating symptoms associated with Androgen Deprivation Therapy comprising administering to a patient in need of such treatment an effective amount of a compound of Formula I: or a pharmaceutically acceptable salt thereof.

Abstract: An electric field sensor may include an atomic vapor cell and a plurality of lasers configured to excite atoms in the vapor cell from a low-energy state to a high-energy state. The sensor may be configured to split signals from the plurality of lasers into multiple polarized signals. The polarized signals may be transmitted through the atomic vapor cell. A subset of the polarized signals may be received by photodetectors after the subset exits the vapor cell. Based on signals from the photodetectors, the electric field sensor may determine an angle of arrival and polarization information about an electric field that is incident upon the atomic vapor cell.

Abstract: Examples are disclosed that relate to generating expressive avatars using multi-modal three-dimensional face modeling and tracking. One example includes a computer system comprising a processor coupled to a storage system that stores instructions. Upon execution by the processor, the instructions cause the processor to receive initialization data describing an initial state of a facial model. The instructions further cause the processor to receive a plurality of multi-modal data signals. The instructions further cause the processor to perform a fitting process using the initialization data and the plurality of multi-modal data signals. The instructions further cause the processor to determine a set of parameters based on the fitting process, wherein the determined set of parameters describes an updated state of the facial model.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: Systems and methods for remotely monitoring the amount of fuel in one or more fuel tanks are disclosed. A fuel monitoring device includes a sensor configured to monitor the operation of a valve coupled to an output of a fuel tank and a network and communication system configured to receive data from the sensor related to the operation of the valve and establish communication with one or more remote systems via a communications network. The fuel monitoring device communicates the data related to the operation of the sensor to a remote server system via the communications network. Based on the data received from the fuel monitoring device and one or more remote systems, the remote server system can determine the amount of fuel remaining in the tank, and can predict when the tank will require additional fuel.

Abstract: An appliance is provided including a fluid flow path and a filter receiving portion. The filter receiving portion comprises an installation assistance feature and is configured to receive a water filter such that it is fluidly connected to the flow path. One or more water filter sensors are included that sense when the water filter is in a first position relative to the filter receiving portion so as to enable initiation of an installation procedure to cause the water filter to move to the installed position. The installation procedure utilizes no the installation assistance feature. At least one controller is provided that receives an indication that the water filter is in a first position and causes, based on the indication, activation of the installation assistance feature to reposition the water filter from the first position towards the installed position.

Abstract: A method of constructing a superconducting switch includes depositing a thin sacrificial layer on top of a substrate. The sacrificial layer is patterned to remove portions of the sacrificial layer except at a first portion of the substrate. A superconducting metal layer is patterned on top of the substrate and on top of the sacrificial layer. The superconducting metal layer is patterned to form a superconducting metal line over the sacrificial layer. The patterned sacrificial layer is etched from under the superconducting metal line to release the metal line from the substrate.

Abstract: A method of constructing a superconducting switch includes providing a substrate. A first superconducting metal line is fabricated on the substrate, wherein the superconducting metal line has a left portion, a right portion, and a center portion patterned along a first crystalline direction of the substrate. One or more etch release holes are provided in the center portion of the first superconducting metal line.

Abstract: An expandable introducer sheath with an interlock dilator. The present technology provides an expandable sheath with a step feature inside its distal opening, and a dilator with an interlock that includes a catch surface configured to engage with the step feature and resist further relative movement so that the body of the dilator is prevented from exiting the distal end of the expandable sheath. This interlocking engagement may allow the dilator to be used to extend and maintain tension on the expandable sheath during insertion into a patient, and then to be retracted from the expandable sheath by pulling the dilator in the opposite direction. The present technology also provides a dilator hub with a spring mechanism configured to achieve and maintain a desired tension on the expandable sheath and to prevent overextension of the expandable sheath when the dilator is being inserted into the expandable sheath.

Abstract: Provided are compositions comprising compounds or precursors to compounds which may be used for a variety of therapeutic applications including, for example, treating and/or preventing a disease or disorder related to reduced or inadequate mitochondrial activity, including aging or stress, diabetes, obesity, and neurodegenerative diseases. The compounds relate generally to urolithins and precursors thereof, including but not limited to ellagitannins and urolithin A. In certain embodiments the compositions are presented in or as food products or nutritional supplements. These same compounds and compositions can also be used advantageously in generally healthy individuals to increase or maintain metabolic rate, decrease percent body fat, increase or maintain muscle mass, manage body weight, improve or maintain mental performance (including memory), improve or maintain muscle performance, improve or maintain mood, and manage stress.

Abstract: System and method for monitoring vital signs of a subject, such as a sleeping patient. A health monitoring device includes a thermal camera such as an uncooled microbolometer array, to monitor breathing, pulse, core temperature, and other vital signs. An audio sensor, e.g., microphone, may be used for monitoring patient respiratory sounds and other sounds. Further information such as pulse rate, PRV, blood pressure, breathing rate and oxygenation level are derived from these signals. The health monitoring device utilizes acquired signals and higher order data in analyzing patient conditions and behaviors. Higher order data include visual data based upon thermal camera signals and audio data based upon audio sensor signals. A processor is configured to output a health determination relating to one or more health parameters of the patient by inputting one or both of the visual data and the audio data into one or more machine learning models.

Abstract: Systems and methods for localizing portable devices are illustrated. One embodiment includes a method for locating a portable device in a network that includes several reference devices. The method measures characteristics of signals transmitted via signal paths between reference devices and a portable device, normalizes the measurements to estimate characteristics of the signal paths, and estimates the likelihood that the portable device is in a particular location. Systems and methods for training prediction models include a method that includes steps for receiving context data for a portable device in a system, wherein the context data includes localization data that describes a location of the portable device, identifying a predicted stationary device based on the context data using a prediction model, identifying a target stationary device from the several stationary devices, training the prediction model based on based on the predicted stationary device and the received input.

Abstract: Optical lenses and associated luminaire are described herein. In one aspect, a lens comprises a light receiving side comprising grooves for receiving light emitting diodes, the grooves defined by a central refractive region and walls comprising total internal reflection faces; and a light extraction side opposite the light receiving side, the light extraction side comprising refractive extraction surfaces, total internal reflection extraction surfaces, or combinations thereof. In some embodiments, luminaire comprises an array of light emitting diodes; and the lens positioned over the array of light emitting diodes.

Abstract: Methods, systems, and media for presenting search results are provided. In accordance with some embodiments, the method comprises: receiving text corresponding to a search query; determining whether a content rating score associated with the search query is below a predetermined threshold, wherein the score is calculated by: identifying a first plurality of search results retrieved using the search query, wherein each search result is associated with one of a plurality of content ratings classes; and calculating the content rating score that is a proportion of search results associated with at least one of the content ratings classes among the first plurality of search results; in response to determining that the content rating score is below the predetermined threshold, identifying a second plurality of search results to be presented based on the search query; and causing the second plurality of search results to be presented.

Abstract: Computing an image depicting a face having an expression with wrinkles is described. A 3D polygon mesh model of a face has a non-neutral expression. A tension map is computed from the 3D polygon mesh model. A neutral texture, a compressed wrinkle texture and an expanded wrinkle texture are computed or obtained from a library. The neutral texture comprises a map of the first face with a neutral expression. The compressed wrinkle texture is a map of the first face formed by aggregating maps of the first face with different expressions using the tension map, and the expanded wrinkle texture comprises a map of the first face formed by aggregating maps of the first face with different expressions using the tension map. A graphics engine may be used to apply the wrinkle textures to the 3D model according to the tension map; and render the image from the 3D model.

Abstract: Technology for generating and displaying a graphical user interface for operating an unmanned aerial vehicle (UAV) is disclosed herein that generates and updates a representation of a spline flight path. In various implementations, a graphical user interface detects user interactions with a remote control device directing the flight control subsystem of the UAV to record keyframes and to compute a spline based on the keyframes during flight. The graphical user interface displays a real-time perspective of the UAV with a representation of the spline and the keyframes overlaying the view. The graphical user interface continually updates the representation as the UAV flies and when the spline is updated as the keyframes are updated.

Abstract: Systems and methods for generating training data are described herein. Pieces of metadata captured by a plurality of networked sensor systems can be captured, where each piece of metadata is associated with a specific set of sensor data captured by one of the plurality of networked sensor systems and includes a set of characteristics for the specific set of captured sensor data. A probabilistic model can be generated based on the received metadata and simulations can be performed based upon a training corpus by generating multiple scenarios, and, for each scenario, a scenario specific version of a particular annotated sample is generated by performing a simulation using the particular annotated sample. The scenario specific versions of annotated samples from the training corpus can be stored as a training data set on the at least one network device.

Abstract: Provided are compositions comprising compounds or precursors to compounds which may be used for a variety of therapeutic applications including, for example, treating and/or preventing a disease or disorder related to reduced or inadequate mitochondrial activity, including aging or stress, diabetes, obesity, and neurodegenerative diseases. The compounds relate generally to urolithins and precursors thereof, including but not limited to ellagitannins and urolithin A. In certain embodiments the compositions are presented in or as food products or nutritional supplements. These same compounds and compositions can also be used advantageously in generally healthy individuals to increase or maintain metabolic rate, decrease percent body fat, increase or maintain muscle mass, manage body weight, improve or maintain mental performance (including memory), improve or maintain muscle performance, improve or maintain mood, and manage stress.

Abstract: A method is provided that includes selecting, by a hardware module, a current parameter set from one or more parameter sets; reading, by the hardware module, a watermark graphic from a location in memory indicated by a parameter in the current parameter set, wherein access to the location in memory is restricted to the hardware module and one or more first trusted applications; blending, by the hardware module, the watermark graphic with a frame of video content; and providing, by the hardware module, the blended frame to a video output.