Abstract: A family of one- and two-photon dyes that have overlapping fluorescence excitation maxima between 365 nm and 425 nm and that are specifically functionalized for coupling to biomolecules. The dyes have defined Stokes shifts such that they produce a continuum of emission wavelengths. The dyes are asymmetrical bis stilbenes. The asymmetry of these dyes facilitates functionalization of the dyes with carboxyl, thiol, aldehyde-reactive or amine-reactive groups, which in turn facilitates coupling with macromolecules. Furthermore, the dyes of the present invention are photostable and have high quantum yields (fluorescence intensity).

Abstract: The present invention is directed to methods and compositions useful as biosensors that specifically interact with various pathogens and other target analytes. The biosensor itself, comprises functionalized dendritic tethers derivatized for attachment to a variety of surfaces as self-assembled monolayers (SAMs) as well as attached binding moieties (sometimes referred to as capture binding ligands). Accordingly, the present invention provides compositions comprising supports comprising surfaces to which the binding moieties (e.g. antibodies) are attached for the detection of target analytes (e.g. pathogens) as well as methods and compositions relating to the attachment of such binding moieties.

Abstract: A method of increasing the multi-photon absorption cross-section of a porphyrin-based photosensitizer by attaching at least one TPA-chromophore at the meso- or beta-positions of a porphyrin structure of the porphyrin-based photosensitizer, and at least one intersystem crossing enhancing substituent to meso- or beta-positions of a porphyrin structure of the porphyrin-based photosensitizer, to thereby increase multi-photon absorption cross-section of the porphyrin-based photosensitizer to at least about 30 GM units at about its maximum wavelength for two-photon absorption. The TPA-chromophore is selected from a group of ?-conjugated structures. The resulting porphyrin-based photosensitizer absorbs two photons of radiation in the range of about 700 nm to about 1300 nm.

Abstract: The present invention is directed to methods and compositions comprising multifunctional (usually bi- or tri-functional) agents that incorporate a targeting moiety, a photo dynamic therapy (PDT) moiety (either one or two photon), and an optional imaging agent (such as a chromophore, contrast agent, etc.).

Abstract: A method of increasing the multi-photon absorption cross-section of a porphyrin-based photosensitizer by attaching at least one TPA-chromophore at the meso- or beta-positions of a porphyrin structure of the porphyrin-based photosensitizer, and at least one intersystem crossing enhancing substituent to meso- or beta-positions of a porphyrin structure of the porphyrin-based photosensitizer, to thereby increase multi-photon absorption cross-section of the porphyrin-based photosensitizer to at least about 30 GM units at about its maximum wavelength for two-photon absorption. The TPA-chromophore is selected from a group of &pgr;-conjugated structures. The resulting porphyrin-based photosensitizer absorbs two photons of radiation in the range of about 700 nm to about 1300 nm.

Abstract: An apparatus and method of detection and visualization of an infrared laser beam using an optically transparent or opaque solid medium doped with at least one active chromophore dye molecule to provide conversion of infrared radiation to visible light by means of two or three-photon absorption followed by emission of a visible photon is provided. A method of verifying mode-lock in mode-locked infrared laser sources and measuring the temporal and spatial shape of ultra short laser pulses having pulse durations between a few femtoseconds and hundreds of picoseconds is also provided.

Abstract: A fluid container assembly including one large, relatively narrow container having an orthogonally shaped recess or depression in a wall portion thereof, and two small fluid containers nested within the recess. The recess has means therein engagable with mating means on each of the small containers for retaining the small containers within the recess against accidental dislodgement and so that the external walls of the containers are flush. Each fluid container is provided with a tamper indicating insert such that tampering renders difficult withdrawing fluid.

Abstract: Apparatus for sensing the height of a stack of fan-folded web being refolded, and controlling its elevation with respect to the arriving web to minimize misfolding.