Abstract: The present application provides spirocyclic lactam compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: Methods, systems, and media for presenting search results are provided. In accordance with some embodiments, the method comprises: receiving text corresponding to a search query; determining whether a content rating score associated with the search query is below a predetermined threshold, wherein the score is calculated by: identifying a first plurality of search results retrieved using the search query, wherein each search result is associated with one of a plurality of content ratings classes; and calculating the content rating score that is a proportion of search results associated with at least one of the content ratings classes among the first plurality of search results; in response to determining that the content rating score is below the predetermined threshold, identifying a second plurality of search results to be presented based on the search query; and causing the second plurality of search results to be presented.

Abstract: Some embodiments include utilizing a multilink media access control (MAC) address structure to support multilink devices (MLDs) that can operate concurrently in more than one link such as extremely high throughput (EHT) access points (APs) and EHT stations (STA), where the multilink MAC address structure is compatible with legacy devices. An EHT AP can utilize a multilink basic service set (BSS) identification (BSSID) MAC address to communicate with an EHT STA identified by a multilink MAC address. Values of the multilink BSSID and the multilink MAC address of the EHT STA are independent of which of the multiple links are used in the communication. In addition, to utilizing a multilink BSSID, the EHT AP can also support unique link-specific MAC addresses to concurrently support legacy and MLD stations. The EHT STA can also utilize unique link-specific MAC addresses that can be different than the EHT AP's link-specific MAC addresses.

Abstract: An analog delay line includes a clock generator, an analog sampling circuit, a bank of analog memory cells, a memory controller, an analog readout circuit, and an analog multiplexer. The clock generator is configured to output plural reception clock signals of different frequencies and plural transmission clock signals of different frequencies, the transmission clock signals offset in accumulated phase relative to the reception clock signals. The analog sampling circuit is controlled by at least one of the reception clock signals, and is configured to output a sequence of sampled voltages of an analog input signal. The memory controller is configured to control a write operation at a write frequency of at least one of the reception clock signals and a read operation at a read frequency of at least one of the transmission clock signals.

Abstract: Fungal artificial chromosome (FAC) vectors are disclosed. A vector can be replicated in a bacterial or a fungal host, and can comprise an insert of heterologous DNA up to about 500 kilobases. A vector can be used for cloning and expressing a secondary metabolite (SM) gene cluster. An insert sequence can be modified by homologous recombination. A vector can be a plasmid comprising bacterial and fungal origins of replication, as well as bacterial and fungal selection marker genes. Also disclosed are vectors that can be integrated into a fungal genome, and dual function vectors which can be replicated in a bacterial or a fungal host and can also be integrated into a fungal genome. Also disclosed are methods of generating plasmid libraries including vectors comprising intact SM gene clusters.

Abstract: Fungal artificial chromosome (FAC) vectors are disclosed. A vector can be replicated in a bacterial or a fungal host, and can comprise an insert of heterologous DNA up to about 500 kilobases. A vector can be used for cloning and expressing a secondary metabolite (SM) gene cluster. An insert sequence can be modified by homologous recombination. A vector can be a plasmid comprising bacterial and fungal origins of replication, as well as bacterial and fungal selection marker genes. Also disclosed are vectors that can be integrated into a fungal genome, and dual function vectors which can be replicated in a bacterial or a fungal host and can also be integrated into a fungal genome. Also disclosed are methods of generating plasmid libraries including vectors comprising intact SM gene clusters.

Abstract: A readout circuit for use with an image sensor includes a comparator coupled to compare a ramp signal from a ramp generator with an output signal from a pixel of a pixel array. A counter is coupled to the comparator to count until the comparator detects that a ramp signal value has reached an output signal value. The counter includes K cascade-coupled dynamic flip-flop circuits to generate the K least significant bits (LSBs) of the N-bit output of the counter. The counter also includes N-K cascade-coupled static flip-flop circuits to generate the N-K most significant bits (MSBs) of the N-bit output of the counter. A latch is coupled to the counter to store a count value generated by the counter after the ramp signal value has reached the output signal value.

Abstract: Methods and systems according to one or more embodiments establish communication across separate IP domains that are on the same layer 2 bridged domain. In an embodiment, a method includes receiving a configuration of a first IP address of a first node on a first side of a switch and a second IP address of a second node on a second side of the switch, wherein the first and second IP addresses are of different domains and are to be translated in each direction with respect to the switch, wherein the switch further comprises an integrated block adapted to do translation at line rate. Based on the configuration, the method also includes modifying, by the switch, packets of an applicable protocol in each direction so that the first and second IP addresses are changed for each domain such that either side of the switch acts as if an opposite side is on the same domain so that layer 2 communication is established.

Abstract: A transmitter circuit coupled to output image data from an image sensor includes a plurality of transmitters. The transmitters may include a plurality of drivers coupled to receive a data signal, and output a differential signal in response to receiving the data signal. A de-emphasis circuit is coupled between a first output of a first driver in the plurality of drivers, and a second output of a second driver in the plurality of drivers. The de-emphasis circuit is coupled to receive a de-emphasis control signal, and in response to receiving the de-emphasis control signal, the de-emphasis circuit reduces a magnitude of the differential signal.

Abstract: Methods and systems according to one or more embodiments establish communication across separate IP domains that are on the same layer 2 bridged domain. In an embodiment, a method includes receiving a configuration of a first IP address of a first node on a first side of a switch and a second IP address of a second node on a second side of the switch, wherein the first and second IP addresses are of different domains and are to be translated in each direction with respect to the switch, wherein the switch further comprises an integrated block adapted to do translation at line rate. Based on the configuration, the method also includes modifying, by the switch, packets of an applicable protocol in each direction so that the first and second IP addresses are changed for each domain such that either side of the switch acts as if an opposite side is on the same domain so that layer 2 communication is established.

Abstract: Fungal artificial chromosome (FAC) vectors are disclosed. A vector can be replicated in a bacterial or a fungal host, and can comprise an insert of heterologous DNA up to about 500 kilobases. A vector can be used for cloning and expressing a secondary metabolite (SM) gene cluster. An insert sequence can be modified by homologous recombination. A vector can be a plasmid comprising bacterial and fungal origins of replication, as well as bacterial and fungal selection marker genes. Also disclosed are vectors that can be integrated into a fungal genome, and dual function vectors which can be replicated in a bacterial or a fungal host and can also be integrated into a fungal genome. Also disclosed are methods of generating plasmid libraries including vectors comprising intact SM gene clusters.

Abstract: Methods and systems according to one or more embodiments establish communication across separate IP domains that are on the same layer 2 bridged domain. In an embodiment, a method includes receiving a configuration of a first IP address of a first node on a first side of a switch and a second IP address of a second node on a second side of the switch, wherein the first and second IP addresses are of different domains and are to be translated in each direction with respect to the switch, wherein the switch further comprises an integrated block adapted to do translation at line rate. Based on the configuration, the method also includes modifying, by the switch, packets of an applicable protocol in each direction so that the first and second IP addresses are changed for each domain such that either side of the switch acts as if an opposite side is on the same domain so that layer 2 communication is established.

Abstract: The invention includes a method of synchronizing objects between first and second object stores. A synchronization manager in accordance with the invention maintains a reference store containing identifying data segments corresponding respectively to a plurality of objects that have previously been synchronized between the first and second object stores. An application program that maintains the first object store has associated interfaces that allow the synchronization manager to compare and manipulate objects. One such interface allows the synchronization manager to submit an identifying data segment associated with a particular object. In response, this interface returns a handle that corresponds to the submitted identifying data segment. Another interface accepts a handle that refers to an identifying data segment, and determines if the object corresponding to the identifying data segment has been changed in the first object store since the last synchronization.

Abstract: A method and system are disclosed for selecting representative information from a video clip to aid in identifying the video clip. The video clip may be a recorded television program and the representative information may be thumbnails determined to a high degree of certainty to include identifying content from the television program. When a user accesses a list of recorded video clips, the identifying information for each clip may be presented to the user to further assist the user in identifying the recorded video clip.

Abstract: The present invention provides N?-(2-halobenzylidene)sulfonylhydrazides of formula I Compounds of formula I are useful for the manufacture of 1-arylsulfonylindazole 5-HT6 ligands.

Abstract: Processes for preparing oxindoles, which can be utilized in the preparation of a variety of useful compounds, and methods for minimizing or preventing N-alkylation of amide containing compounds, including oxindoles, are provided.

Abstract: A synchronization system synchronizes objects between a portable computer and a desktop computer. The portable computer is capable of communicating with a storage volume that can become inaccessible to the portable computer. The system identifies storage volumes currently available to the portable computer and identifies storage volumes previously accessible to the potable computer, but not currently accessible to the portable computer. Objects contained in storage volumes that are currently accessible to the portable computer are then synchronized between the base computer and the portable computer. During the synchronization process, the system ignores objects stored on volumes that are not currently accessible to the portable computer.

Abstract: A turbocharger speed controller includes a rising rate limiter having an input receiving a turbocharger speed signal and an output producing a rate limited turbocharger speed signal, a high envelope filter having an input receiving the rate limited turbocharger speed signal and an output producing a filtered and rate limited turbocharger speed signal, a turbocharger speed control signal generator having an input receiving the filtered and rate limited turbocharger speed signal and an output producing a turbocharger speed control signal based on comparison of the filtered and rate limited turbocharger speed signal with a desired turbocharger speed, and a swallowing capacity control mechanism responsive to the turbocharger speed control signal to vary a swallowing capacity of the turbocharger.

Abstract: A system is disclosed for controlling the current used by an actuator to control actuator position. A control circuit is configured to control the actuator current to a value at or near the minimum current required to sustain the actuator in a desired position in order to maintain the actuator operating temperature below a specified maximum actuator temperature.