Patents by Inventor Charlie Liu
Charlie Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220398245Abstract: The present disclosure relates to time aware caching. One method includes receiving an API request for data from a database, wherein the request defines a time window associated with the data, creating a first and second query based on the request, wherein the first query corresponds to a first chunk of the time window, and wherein the second query corresponds to a second chunk of the time window, hashing a first statement associated with the first query to produce a first key and hashing a second statement associated with the second query to produce a second key, retrieving a first portion of the data corresponding to the first chunk of the time window from cache responsive to a determination that the first key is in the cache, and retrieving a second portion of the data corresponding to the second chunk of the time window from the database responsive to a determination that the second key is not in the cache.Type: ApplicationFiled: June 11, 2021Publication date: December 15, 2022Applicant: VMware, Inc.Inventors: Charlie Liu, Chris Dent, Akash Gangil
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Patent number: 11008279Abstract: Provided is a method for purifying 1,5-pentanediamine comprising: providing 1,5-pentanediamine to be purified and treating the 1,5-pentanediamine to be purified by a reduction reaction to obtain purified 1,5-pentanediamine. Meanwhile, further provided is 1,5-pentanediamine prepared by the method. The purification method has a concise process and a simple operation, and is suitable for industrial production, and can significantly improve the quality of 1,5-pentanediamine.Type: GrantFiled: December 5, 2019Date of Patent: May 18, 2021Assignees: CATHAY BIOTECH INC., CIBT AMERICA INC.Inventors: Bingbing Qin, Charlie Liu, Shanshi Guo, Benliang Hou, Xiucai Liu
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Patent number: 10619148Abstract: Provided are a lysine decarboxylase immobilized cell and preparation method thereof.Type: GrantFiled: February 3, 2015Date of Patent: April 14, 2020Assignees: Cathay Biotech Inc., CIBT America Inc.Inventors: Lijun Yu, Naiqiang Li, Charlie Liu, Xiucai Liu
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Publication number: 20200109104Abstract: Provided is a method for purifying 1,5-pentanediamine comprising: providing 1,5-pentanediamine to be purified and treating the 1,5-pentanediamine to be purified by a reduction reaction to obtain purified 1,5-pentanediamine. Meanwhile, further provided is 1,5-pentanediamine prepared by the method. The purification method has a concise process and a simple operation, and is suitable for industrial production, and can significantly improve the quality of 1,5-pentanediamine.Type: ApplicationFiled: December 5, 2019Publication date: April 9, 2020Applicants: CIBTAmerica Inc., Cathay Biotech Inc.Inventors: Bingbing Qin, Charlie Liu, Shanshi Guo, Benliang Hou, Xiucai Liu
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Patent number: 10538481Abstract: Provided is a method for purifying 1,5-pentanediamine comprising: providing 1,5-pentanediamine to be purified and treating the 1,5-pentanediamine to be purified by a reduction reaction to obtain purified 1,5-pentanediamine. Meanwhile, further provided is 1,5-pentanediamine prepared by the method. The purification method has a concise process and a simple operation, and is suitable for industrial production, and can significantly improve the quality of 1,5-pentanediamine.Type: GrantFiled: December 17, 2014Date of Patent: January 21, 2020Assignees: Cathay Biotech Inc., CIBT America Inc.Inventors: Bingbing Qin, Charlie Liu, Shanshi Guo, Benliang Hou, Xiucai Liu
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Patent number: 10487176Abstract: The present invention provides a method for preparing nylon salt, which comprises mixing 1,5-pentanediamine, water and dicarboxylic acid at a temperature of 65 to 120° C. to obtain a nylon salt, wherein the amount of the water is 2% to 12% by weight based on the total weight of the 1,5-pentanediamine and the dicarboxylic acid. The present invention also provides a nylon salt. According to the present method for preparing nylon salt, the incomplete reaction between the 1,5-pentanediamine and the dicarboxylic acid, which is caused by the nylon salt present during the preparation in a solid state, can be avoided; the reaction between the 1,5-pentanediamine and the dicarboxylic acid can be significantly speeded up, and the reaction time is accordingly shorten. Consequently, the content of diamine and dicarboxylic acid remained in the resulting nylon salt is very low. In addition, the final nylon salt product, which present in a solid state, makes it easier to be stored and transported.Type: GrantFiled: December 17, 2014Date of Patent: November 26, 2019Assignees: Cathay Biotech Inc., CIBT America Inc.Inventors: Chen Yang, Bingbing Qin, Yi Zheng, Charlie Liu, Naiqiang Li, Xiucai Liu
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Patent number: 10464880Abstract: The present invention relates to a method for the purification of cadaverine from an aqueous cadaverine salt composition comprising one or more involatile impurities, the method comprising: (1) mixing the aqueous cadaverine salt composition with one or more bases to provide an aqueous cadaverine composition having a pH of at least about 12; (2) distilling or evaporating the aqueous cadaverine composition to produce an aqueous cadaverine solution, wherein one or more solvents are added to the evaporation/distillation system before the evaporation/distillation stops, and the one or more solvents comprise at least one or more high boiling point (HBP) solvents having a boiling point of at least 185° C. (1 atm); and (3) subjecting the aqueous cadaverine solution to one or more rectification steps to provide a cadaverine product.Type: GrantFiled: February 21, 2018Date of Patent: November 5, 2019Assignees: CATHAY BIOTECH INC., CIBT AMERICA INC.Inventors: Xiucai Liu, Charlie Liu, Bingbing Qin, Naiqiang Li, Yang Chen
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Patent number: 10221407Abstract: One aspect of the present disclosure relates to a stabilized recombinant expression plasmid vector comprising a polynucleotide encoding an antitoxin gene which expresses a polypeptide that neutralizes a polypeptide toxic to a host cell, the toxic polypeptide being expressed by a toxin gene in the host cell, and a polynucleotide encoding a polypeptide expression product, and the stabilized recombinant expression plasmid vector is derived from a Hafnia alvei autonomously replicable backbone plasmid. Other aspects of the present disclosure relate to a transformant transformed with the stabilized recombinant expression plasmid vector disclosed herein, a method of producing biobased cadaverine using the transformant disclosed herein, and biobased cadaverine prepared by the method disclosed herein. Another aspect of the present disclosure relates to a polyamide formed using biobased cadaverine disclosed herein, and a composition thereof.Type: GrantFiled: January 11, 2016Date of Patent: March 5, 2019Assignees: Cathay Industrial Biotech Ltd., Cathay R&D Center Co., Ltd.Inventors: Zhenhua Pang, Naiqiang Li, Charlie Liu, Xiucai Liu
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Publication number: 20180215698Abstract: The present invention relates to a method for the purification of cadaverine from an aqueous cadaverine salt composition comprising one or more involatile impurities, the method comprising: (1) mixing the aqueous cadaverine salt composition with one or more bases to provide an aqueous cadaverine composition having a pH of at least about 12; (2) distilling or evaporating the aqueous cadaverine composition to produce an aqueous cadaverine solution, wherein one or more solvents are added to the evaporation/distillation system before the evaporation/distillation stops, and the one or more solvents comprise at least one or more high boiling point (HBP) solvents having a boiling point of at least 185° C. (1 atm); and (3) subjecting the aqueous cadaverine solution to one or more rectification steps to provide a cadaverine product.Type: ApplicationFiled: February 21, 2018Publication date: August 2, 2018Applicants: CATHAY R&D CENTER CO., LTD., CATHAY INDUSTRIAL BIOTECH LTD.Inventors: Xiucai LIU, Charlie LIU, Bingbing QIN, Naiqiang LI, Yang CHEN
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Patent number: 9919996Abstract: The invention relates to a method for preparing cadaverine comprising: (1) obtaining an aqueous cadaverine salt composition from a fermentation system; (2) adjusting the pH of the aqueous cadaverine salt composition to a pH of at least about 12 by adding an inorganic base composition to provide a first composition comprising an aqueous cadaverine composition having a pH of at least about 12 and a solid composition comprising one or more alkali metal sulfates; (3) subjecting the first composition to solid-liquid separation without organic solvent extraction to provide the aqueous cadaverine composition and the solid composition; (4) distilling or evaporating the aqueous cadaverine composition of step (3) without organic solvent extraction to provide purified cadaverine; (5) preparing a saturated solution of the alkali metal sulfate(s) from the solid composition of step (3) at a temperature of about 35-40° C.Type: GrantFiled: January 16, 2017Date of Patent: March 20, 2018Assignees: CATHAY R&D CENTER CO., LTD., CATHAY INDUSTRIAL BIOTECH LTD.Inventors: Xiucai Liu, Charlie Liu, Bingbing Qin, Naiqiang Li, XiaoMing Li
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Patent number: 9914694Abstract: The present invention relates to a method for the purification of cadaverine from an aqueous cadaverine salt composition comprising one or more involatile impurities, the method comprising: (1) mixing the aqueous cadaverine salt composition with one or more bases selected from the group consisting of Ca(OH)2, Mg(OH)2, CaO and MgO to provide an aqueous cadaverine composition; and (2) distilling or evaporating the aqueous cadaverine composition to produce purified cadaverine; wherein one or more solvents are added to the evaporation/distillation system before the evaporation/distillation stops, and the one or more solvents comprise at least one or more high boiling point (HBP) solvents.Type: GrantFiled: January 27, 2017Date of Patent: March 13, 2018Assignees: CATHAY R&D CENTER CO., LTD., CATHAY INDUSTRIAL BIOTECH LTD.Inventors: Xiucai Liu, Charlie Liu, Bingbing Qin, Naiqiang Li, Yang Chen
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Patent number: 9896409Abstract: One aspect of the invention relates to a method for the purification of cadaverine from an aqueous cadaverine composition comprising one or more involatile impurities, the method comprising: a) distilling or evaporating the aqueous cadaverine composition wherein one or more solvents are added to the evaporation/distillation system before the evaporation/distillation starts, during the evaporation/distillation and/or after the evaporation/distillation substantially stops when no more evaporation/distillation is observed to produce purified cadaverine, wherein the evaporation or distillation is done at a heating temperature of about 80° C. to about 180° C. and under a pressure of 1 atm or lower, and the one or more solvents comprise at least one or more high boiling point (HBP) solvents having a boiling point of at least about 185° C. (1 atm); and b) recovering the one or more HBP solvents.Type: GrantFiled: January 27, 2017Date of Patent: February 20, 2018Assignees: CATHAY R&D CENTER CO., LTD., CATHAY INDUSTRIAL BIOTECH LTD.Inventors: Xiucai Liu, Charlie Liu, Bingbing Qin, Naiqiang Li, XiaoMing Li
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Publication number: 20180002272Abstract: Provided is a method for purifying 1,5-pentanediamine comprising: providing 1,5-pentanediamine to be purified and treating the 1,5-pentanediamine to be purified by a reduction reaction to obtain purified 1,5-pentanediamine. Meanwhile, further provided is 1,5-pentanediamine prepared by the method. The purification method has a concise process and a simple operation, and is suitable for industrial production, and can significantly improve the quality of 1,5-pentanediamine.Type: ApplicationFiled: December 17, 2014Publication date: January 4, 2018Applicants: Cathay R&D Center Co., Ltd., Cathay Industrial Biotech Ltd.Inventors: Bingbing Qin, Charlie Liu, Shanshi Guo, Benliang Hou, Xiucai Liu
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Publication number: 20180002686Abstract: Provided are a lysine decarboxylase immobilized cell and preparation method thereof.Type: ApplicationFiled: February 3, 2015Publication date: January 4, 2018Applicants: Cathay R&D Center Co., Ltd., Cathay Industrial Biotech Ltd.Inventors: Lijun Yu, Naiqiang Li, Charlie Liu, Xiucai Liu
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Publication number: 20170349705Abstract: The present invention provides a method for preparing nylon salt, which comprises mixing 1,5-pentanediamine, water and dicarboxylic acid at a temperature of 65 to 120° C. to obtain a nylon salt, wherein the amount of the water is 2% to 12% by weight based on the total weight of the 1,5-pentanediamine and the dicarboxylic acid. The present invention also provides a nylon salt. According to the present method for preparing nylon salt, the incomplete reaction between the 1,5-pentanediamine and the dicarboxylic acid, which is caused by the nylon salt present during the preparation in a solid state, can be avoided; the reaction between the 1,5-pentanediamine and the dicarboxylic acid can be significantly speeded up, and the reaction time is accordingly shorten. Consequently, the content of diamine and dicarboxylic acid remained in the resulting nylon salt is very low. In addition, the final nylon salt product, which present in a solid state, makes it easier to be stored and transported.Type: ApplicationFiled: December 17, 2014Publication date: December 7, 2017Applicants: Cathay R&D Center Co., Ltd., Cathay Industrial Biotech Ltd.Inventors: Chen Yang, Bingbing Qin, Yi Zheng, Charlie Liu, Naiqiang Li, Xiucai Liu
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Publication number: 20170137369Abstract: One aspect of the invention relates to a method for the purification of cadaverine from an aqueous cadaverine composition comprising one or more involatile impurities, the method comprising: a) distilling or evaporating the aqueous cadaverine composition wherein one or more solvents are added to the evaporation/distillation system before the evaporation/distillation starts, during the evaporation/distillation and/or after the evaporation/distillation substantially stops when no more evaporation/distillation is observed to produce purified cadaverine, wherein the evaporation or distillation is done at a heating temperature of about 80° C. to about 180° C. and under a pressure of 1 atm or lower, and the one or more solvents comprise at least one or more high boiling point (HBP) solvents having a boiling point of at least about 185° C. (1 atm); and b) recovering the one or more HBP solvents.Type: ApplicationFiled: January 27, 2017Publication date: May 18, 2017Applicants: CATHAY R&D CENTER CO., LTD., CATHAY INDUSTRIAL BIOTECH LTD.Inventors: Xiucai LIU, Charlie LIU, Duanfang DAI, Bingbing QIN, Naiqiang LI
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Publication number: 20170137368Abstract: The present invention relates to a method for the purification of cadaverine from an aqueous cadaverine salt composition comprising one or more involatile impurities, the method comprising: (1) mixing the aqueous cadaverine salt composition with one or more bases selected from the group consisting of Ca(OH)2, Mg(OH)2, CaO and MgO to provide an aqueous cadaverine composition; and (2) distilling or evaporating the aqueous cadaverine composition to produce purified cadaverine; wherein one or more solvents are added to the evaporation/distillation system before the evaporation/distillation stops, and the one or more solvents comprise at least one or more high boiling point (HBP) solvents.Type: ApplicationFiled: January 27, 2017Publication date: May 18, 2017Applicants: CATHAY R&D CENTER CO., LTD., CATHAY INDUSTRIAL BIOTECH LTD.Inventors: Xiucai LIU, Charlie LIU, Duanfang DAI, Bingbing QIN, Naiqiang LI
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Publication number: 20170121273Abstract: The invention relates to a method for preparing cadaverine comprising: (1) obtaining an aqueous cadaverine salt composition from a fermentation system; (2) adjusting the pH of the aqueous cadaverine salt composition to a pH of at least about 12 by adding an inorganic base composition to provide a first composition comprising an aqueous cadaverine composition having a pH of at least about 12 and a solid composition comprising one or more alkali metal sulfates; (3) subjecting the first composition to solid-liquid separation without organic solvent extraction to provide the aqueous cadaverine composition and the solid composition; (4) distilling or evaporating the aqueous cadaverine composition of step (3) without organic solvent extraction to provide purified cadaverine; (5) preparing a saturated solution of the alkali metal sulfate(s) from the solid composition of step (3) at a temperature of about 35-40° C.Type: ApplicationFiled: January 16, 2017Publication date: May 4, 2017Applicants: CATHAY R&D CENTER CO., LTD., CATHAY INDUSTRIAL BIOTECH LTD.Inventors: Xiucai LIU, Charlie LIU, Duanfang DAI, Bingbing QIN, Naiqiang LI
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Patent number: 9556106Abstract: One aspect of the invention relates to a method for the purification of cadaverine from an aqueous cadaverine composition comprising one or more involatile impurities, the method comprising obtaining cadaverine from evaporation or distillation of the aqueous cadaverine composition wherein one or more solvents are added to the evaporation/distillation system before the evaporation/distillation starts, during the evaporation/distillation and/or after the evaporation/distillation substantially stops when no more evaporation/distillation is observed; wherein the one or more solvents comprise at least one or more high boiling point (HBP) solvents. In certain embodiments, cadaverine may be evaporated/distilled at an unexpectedly lower heating temperature for an unexpectedly shorter heating time to provide a desired yield. Because cadaverine may decompose at high temperature, the unexpectedly lower heating temperature and unexpectedly shorter heating time decrease the undesired cadaverine decomposition.Type: GrantFiled: January 28, 2013Date of Patent: January 31, 2017Assignees: CATHAY R&D CENTER CO., LTD., CATHAY INDUSTRIAL BIOTECH LTD.Inventors: Xiucai Liu, Charlie Liu, Duanfang Dai, Bingbing Qin, Naiqiang Li
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Patent number: 9546127Abstract: One aspect of the invention relates to a method for reducing salt content in an aqueous cadaverine salt composition comprising adjusting the pH of the aqueous cadaverine salt composition to provide a first composition comprising an aqueous cadaverine composition and a solid composition, wherein the pH of the aqueous cadaverine composition is at least about 12; and removing the solid composition from the first composition to provide the aqueous cadaverine composition. Another aspect of the invention relates to a method for the purification of cadaverine from an aqueous cadaverine salt composition using the salt-reducing method described herein; and obtaining cadaverine from the aqueous cadaverine composition.Type: GrantFiled: January 28, 2013Date of Patent: January 17, 2017Assignees: CATHAY R&D CENTER CO., LTD., CATHAY INDUSTRIAL BIOTECH LTD.Inventors: Xiucai Liu, Charlie Liu, Duanfang Dai, Bingbing Qin, Naiqiang Li