Patents by Inventor Charlotta Mellin

Charlotta Mellin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6465687
    Abstract: Novel thyroid receptor ligands are provided which have the general formula (I) where R1 is alkyl of 1 to 4 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 3 carbons or cycloalkyl of 3 to 5 carbons, at least one of R2 and R3 being other than hydrogen; n is an integer from 0 to 4; R4 is an aliphatic hydrocarbon, an aromatic hydrocarbon, carboxylic acid ester thereof, alkenyl carboxylic acid or ester thereof, hydroxy, halogen, cyano, or a phosphonic acid or an ester thereof, or a pharmaceutically acceptible salt thereof. A method for treating diseases associated with metabolism dysfunction or which are dependent on the expression of a T3 regulated gene, such as obesity, hypercholesterolemia, osteoporosis, hypothyroidism, and goiter, is also provided.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: October 15, 2002
    Assignee: Karo Bio AB
    Inventors: Yi-Lin Li, Ye Liu, Asa Hedfors, Johan Malm, Charlotta Mellin, Minsheng Zhang
  • Patent number: 5854282
    Abstract: The invention provides compounds according to the formula ##STR1## in which: Ha=I or BrX=CH.sub.2 or C=OR.sup.1 =C.sub.1-4 alkylR.sup.2 =--NHSO.sub.2 R.sup.3 ;--NHCOR.sup.3 ; or--NHCONHR.sup.3where R.sup.3 =--CF.sub.3,C.sub.1-3 alkyl, 4-R.sup.4 C.sub.6 H.sub.4 --;where R.sup.4 =C.sub.1-4 alkoxy-; hydroxy-; fluoro-; or nitro-;or a pharmaceutically acceptable salt thereof.The compounds may particularly be used in the treatment of T3 regulated gene disorders and diseases.
    Type: Grant
    Filed: April 7, 1997
    Date of Patent: December 29, 1998
    Assignee: Karo Bio AB
    Inventor: Charlotta Mellin