Patents by Inventor Charon R. Ganellin

Charon R. Ganellin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazole compounds and their therapeutic applications
    Patent number: 5559113
    Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the specification having antagonist properties to histamine H.sub.3 -receptors.
    Type: Grant
    Filed: January 28, 1994
    Date of Patent: September 24, 1996
    Assignees: Institut National de la Sante et de la Recherche Medicale, Societe Civile Bioprojet
    Inventors: Jean-Charles Schwartz, Jean-Michel Arrang, Monique Garbarg, Jeanne-Marie Lecomte, Charon R. Ganellin, Abdellatif Fkyerat, Wasyl Tertiuk, Walter Schunack, Ralph Lipp, Holger Stark, Katja Purand
  • Method of inducing a histamine agonist action on H.sub.2 receptors
    Patent number: 5321039
    Abstract: The invention claims as drugs which are active as agonists of the histamine H.sub.3 receptor, the O-[2-(4(5-imidazolyl)-ethyl] isothiourea, 4-(4(5)-imidazolyl) butyramidine and S-[2-(4(5)-imidazolyl)-ethyl] isourea as well as their N-methyl derivatives, these compounds being useful for the preparation of drugs to be used as hypnotic, sleep-inducer, tranquillizer, sedative, anxiolytic, anti-asthmatic and anti-inflammatory agents, notably for the bronchi, the skin or the eyes, or as anti-gastric ulcer agents.
    Type: Grant
    Filed: September 6, 1991
    Date of Patent: June 14, 1994
    Assignees: Societe Civile Bioprojet, Institute National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Jean C. Schwartz, Monique Garbarg, Jean M. Arrang, Charon R. Ganellin, Jeanne M. Lecomte
  • Pharmaceutical compositions
    Patent number: 4649138
    Abstract: S-(Aminoalkyl)isothioureas which have immunosuppressant activity. Two specific compounds are 2-(3-dimethylaminopropylthio)-2-imidazoline and N,N'-dimethyl-S-(3-dimethylaminopropyl)isothiourea.
    Type: Grant
    Filed: September 28, 1984
    Date of Patent: March 10, 1987
    Assignee: SmithKline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin, Margaret R. Vickers
  • 2-substituted alkylaminopyrimidones useful as H.sub.2 -antagonists and antiinflamatory agents
    Patent number: 4639519
    Abstract: The compounds are isoureas and isothioureas which have an O- or S-alkylpyrimidone substituent and which are histamine H.sub.2 -antagonists and antiinflammatory agents.A specific compound of this invention is 2-[5-(O-isoureido)pentylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
    Type: Grant
    Filed: May 1, 1985
    Date of Patent: January 27, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Charon R. Ganellin, Robert J. Ife, David A. A. Owen
  • Pharmacologically active compounds
    Patent number: 4600720
    Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolymethylthio)ethylamino]-4-pyrimidone.
    Type: Grant
    Filed: June 5, 1985
    Date of Patent: July 15, 1986
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: Graham J. Durant, John C. Emmett, Charon R. Ganellin
  • Unsymmetrical guanidino, thioureido, isothioureido and nitromethyleneamino derivatives
    Patent number: 4578388
    Abstract: The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino). N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido) groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido]p ropane. The compounds of this invention are inhibitors of H-2 histamine receptors.
    Type: Grant
    Filed: June 30, 1983
    Date of Patent: March 25, 1986
    Assignee: SmithKline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin
  • Heterocyclic alkylaminoheterocycles
    Patent number: 4578459
    Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.
    Type: Grant
    Filed: June 8, 1984
    Date of Patent: March 25, 1986
    Assignee: SmithKline & French Laboratories Limited
    Inventors: Graham J. Durant, John C. Emmett, Charon R. Ganellin
  • 2-Substituted alkylaminopyrimidones
    Patent number: 4558128
    Abstract: The compounds are isoureas and isothioureas which have an O- or S- alkylpyrimidone substituent and which are histamine H.sub.2 -antagonists and antiinflammatory agents. A specific compound of this invention is 2-[5-(O-isoureido)pentylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
    Type: Grant
    Filed: November 9, 1983
    Date of Patent: December 10, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Charon R. Ganellin, Robert J. Ife, David A. A. Owen
  • Pharmacologically active compounds
    Patent number: 4537779
    Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: August 27, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, John C. Emmett, Charon R. Ganellin
  • Pharmacologically active isoxazole and triazole compounds
    Patent number: 4499101
    Abstract: The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. Two compounds of this invention are N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiourea and N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-N"-cyanoguanidine.
    Type: Grant
    Filed: February 4, 1983
    Date of Patent: February 12, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin
  • Pharmaceutical compositions
    Patent number: 4490387
    Abstract: S-(Aminoalkyl)isothiourens which have immunosuppressant activity. Two specific compounds are 2-(3-dimethylaminopropylthio)-2-imidazoline and N,N'-dimethyl-S-(3-dimethylaminopropyl)isothiourea.
    Type: Grant
    Filed: January 17, 1983
    Date of Patent: December 25, 1984
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin, Margaret R. Vickers
  • Pharmacologically active compounds
    Patent number: 4470985
    Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.
    Type: Grant
    Filed: April 15, 1983
    Date of Patent: September 11, 1984
    Assignee: SmithKline & French Laboratories Limited
    Inventors: Graham J. Durant, John C. Emmett, Charon R. Ganellin
  • 1,2,4-Triazines
    Patent number: 4467087
    Abstract: Heterocyclic alkyl(or methylthioalkyl)amino-1,2,4-triazine compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors.
    Type: Grant
    Filed: September 24, 1982
    Date of Patent: August 21, 1984
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, John C. Emmett, Charon R. Ganellin
  • Azolyl alkylthioureas and guanidines alkylaminonitroethylene compounds
    Patent number: 4440775
    Abstract: The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: June 18, 1982
    Date of Patent: April 3, 1984
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin, Geoffrey R. Owen, Rodney C. Young
  • Isoureas and isothioureas
    Patent number: 4439435
    Abstract: The compounds are isoureas and isothioureas which have an O- or S- alkylpyrimidone substituent and which are histamine H.sub.2 -antagonists and antiinflammatory agents. A specific compound of this invention is 2-[5-(O-isoureido)pentylamino]-5-(6-methyl-3-pyridyl-methyl)-4-pyrimidone.
    Type: Grant
    Filed: August 6, 1981
    Date of Patent: March 27, 1984
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: Charon R. Ganellin, Robert J. Ife, David A. A. Owen
  • Pharmacologically active compounds
    Patent number: 4438127
    Abstract: Amidinoformic acids and amidinosulphinic acids which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are N-[2-(5-methyl-4-imidazolylmethylthio)-ethyl]amidinoformic acid and N-methyl-N'-[2-(5-methyl-4-imidazolylmethylthio)ethyl]amidiniosulphinic acid.
    Type: Grant
    Filed: March 7, 1983
    Date of Patent: March 20, 1984
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin, Rodney C. Young
  • Alkoxypyridyl alkylamines
    Patent number: 4426526
    Abstract: The compounds are alkoxypyridine compounds which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are N-cyano-N'-methyl-N"-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]guanidine and 1-methylamino-1-[2-((3-methoxy-2-pyridyl)methylthio)ethylamino]-2-nitroeth ylene.
    Type: Grant
    Filed: November 19, 1980
    Date of Patent: January 17, 1984
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin, George S. Sach
  • Heterocyclic thioureas, isothioureas, guanidines and nitromethylene-amidines
    Patent number: 4405621
    Abstract: The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido)groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido]p ropane. The compounds of this invention are inhibitors of H-2 histamine receptors.
    Type: Grant
    Filed: June 11, 1981
    Date of Patent: September 20, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin
  • Pharmacologically active compounds
    Patent number: 4399142
    Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolymethylthio)ethylamino]-4-pyrimidone.
    Type: Grant
    Filed: March 31, 1982
    Date of Patent: August 16, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, John C. Emmett, Charon R. Ganellin
  • Imidazole compounds and their therapeutic applications
    Patent number: RE37303
    Abstract: A compound selected from the group consisting of a compound of the formula wherein the substituents are defined as in the specification having antagonist properties to histamine H3-receptors.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: July 31, 2001
    Assignees: Institut National del la Sante et de la Recherche Medicale, Societe Civile Bioprojet
    Inventors: Jean-Charles Schwartz, Jean-Michel Arrang, Monique Garbarg, Jeanne-Marie Lecomte, Charon R. Ganellin, Abdellatif Fkyerat, Wasyl Tertiuk, Walter Schunack, Ralph Lipp, Holger Stark, Katja Purand