Abstract: Compounds that activate pyruvate kinase R can be used for the treatment of sickle cell disease (SCD). Methods and compositions for the treatment of SCD are provided herein, including a therapeutic compound designated as Compound 1.

Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: Provided is a storage container that includes a body that defines an interior of the storage container, and a bag contained within the interior of the storage container. The bag is constructed of an elastomer, includes an opening, and defines a bag interior configured to contain a material. The storage container further includes a material valve assembly coupled to a portion of the body. The material valve assembly is coupled to the bag and configured to selectively provide fluid communication between the bag interior and an external environment of the storage container.

Abstract: Mobile training labs for training gas technicians are disclosed. The mobile training labs can include a towable trailer comprising a body having a plurality of walls at least partially defining a hollow interior, an axle having at least two wheels disposed thereon to support the body, and a tow hitch. The mobile training labs can also include at least one training bay connected to the towable trailer such that the at least one training bay is configured to be accessed from an exterior of the towable trailer. The at least one training bay can include a work bench and a mock service entrance that is representative of a commercial or residential gas service entrance.

Abstract: A catcher bag for ground tending machine such as a power lawn mower. The catcher bag is constructed of biodegradable perforated paper and replaces an O.E.M. fabric catcher bag. The disclosed catcher bag can mount on a variety of O.E.M. catcher bag frames of O.E.M. rear discharge lawn mowers, and greatly eases the effort of collecting and disposing of lawn clippings and leaf debris by eliminating labor-intensive, cumbersome, and often messy/dusty steps in transferring debris from a fabric catcher bag into a standard paper lawn refuse disposal bag.

Abstract: Merchant accounts associated with sales of counterfeit or other prohibited goods may be automatically discovered by identifying websites that have traits characteristic of those that sell prohibited goods. Automated browsing sessions are established with the respective websites, in which communication traffic, page identifiers, and page contents are captured for analysis. During each of the automated sessions, a website is automatically navigated to locate and visit a payment-processing page associated with a known payment processor. The captured data from the session is analyzed to identify a merchant account established with the payment processor for receiving proceeds from sales of prohibited goods. In some cases, the captured data is analyzed to identify a common merchant and/or page identifier that was encountered in multiple sessions. Multiple otherwise unrelated websites may thereby be grouped together as being likely associated with a common merchant account.

Abstract: Merchant accounts associated with sales of counterfeit or other prohibited goods may be automatically discovered by identifying websites that have traits characteristic of those that sell prohibited goods. Automated browsing sessions are established with the respective websites, in which communication traffic, page identifiers, and page contents are captured for analysis. During each of the automated sessions, a website is automatically navigated to locate and visit a payment-processing page associated with a known payment processor. The captured data from the session is analyzed to identify a merchant account established with the payment processor for receiving proceeds from sales of prohibited goods. In some cases, the captured data is analyzed to identify a common merchant and/or page identifier that was encountered in multiple sessions. Multiple otherwise unrelated websites may thereby be grouped together as being likely associated with a common merchant account.