Patents by Inventor Chawnshang Chang

Chawnshang Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING PROSTATE CANCER
    Publication number: 20180055915
    Abstract: The invention provides novel therapeutically methods and pharmaceutical compositions for treating prostate cancer with increased survival rate and improved treatment outcome. Methods and compositions of the invention can be used to prevent, delay, reduce and/or drug resistance and to increase, restore and/or prolong the effective treatment of prostate cancer with anti-androgen compounds.
    Type: Application
    Filed: March 10, 2017
    Publication date: March 1, 2018
    Inventors: Chawnshang Chang, Shu-Yuan Yeh
  • Methods for treating prostate cancer
    Patent number: 9463242
    Abstract: Disclosed herein are methods and compositions for reducing the recurrence of prostate cancer and for treating prostate cancer.
    Type: Grant
    Filed: May 3, 2012
    Date of Patent: October 11, 2016
    Assignee: UNIVERSITY OF ROCHESTER
    Inventor: Chawnshang Chang
  • METHODS FOR TREATING PROSTATE CANCER
    Publication number: 20140105908
    Abstract: Disclosed herein are methods and compositions for reducing the recurrence of prostate cancer and for treating prostate cancer.
    Type: Application
    Filed: May 3, 2012
    Publication date: April 17, 2014
    Applicant: UNIVERSITY OF ROCHESTER
    Inventor: Chawnshang Chang
  • Methods and compositions related to TR4 ligand
    Patent number: 8524455
    Abstract: Disclosed are compositions and methods related to TR4 and aging.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: September 3, 2013
    Assignee: University of Rochester
    Inventor: Chawnshang Chang
  • Curcumin analogues and uses thereof
    Patent number: 8198323
    Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: June 12, 2012
    Assignees: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience Corporation
    Inventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
  • PSA AND KLK2 AS THERAPEUTIC TARGETS AND MOLECULES INHIBITING PSA AND KLK2
    Publication number: 20110177059
    Abstract: Disclosed herein are compositions and methods relating to prostate-specific antigen (PSA), KLK2 and androgen receptor. Further provided are methods and compositions for inhibiting PSA and/or KLK2 activity. Further provided are compositions and methods for treating or preventing cancer.
    Type: Application
    Filed: August 5, 2009
    Publication date: July 21, 2011
    Applicant: UNIVERSITY OF ROCHESTER
    Inventor: Chawnshang Chang
  • METHODS AND COMPOSITIONS RELATED TO TR4 LIGAND
    Publication number: 20110028538
    Abstract: Disclosed are compositions and methods related to TR4 and aging.
    Type: Application
    Filed: July 23, 2010
    Publication date: February 3, 2011
    Applicant: UNIVERSITY OF ROCHESTER
    Inventor: Chawnshang Chang
  • NOVEL CURCUMIN ANALOGUES AND USES THEREOF
    Publication number: 20100197784
    Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
    Type: Application
    Filed: April 12, 2010
    Publication date: August 5, 2010
    Applicants: The University of North Carlina at Chapel Hill, The University of Rochester Medical Center, Androscience Corporation
    Inventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
  • Curcumin analogues and uses thereof
    Patent number: 7709535
    Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: May 4, 2010
    Assignees: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience Corporation
    Inventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
  • Non-androgen dependent roles for androgen receptor in liver cancer
    Publication number: 20100048676
    Abstract: Disclosed are compositions and methods for modulating AR activity, such as non-androgen dependent AR activity. Also disclosed are compositions and methods for diagnosing beast cancer and for inhibiting liver cancer growth. In addition, disclosed are methods for identifying molecules that inhibit AR in non-androgen dependent ways.
    Type: Application
    Filed: August 4, 2009
    Publication date: February 25, 2010
    Applicant: University of Rochester
    Inventor: Chawnshang Chang
  • Prostate Epithelial Androgen Receptor Suppresses Prostate Growth and Tumor Invasion
    Publication number: 20100017900
    Abstract: Described herein is the generation of the first conditional knockout AR (pes-ARKO) mice that lack AR only in prostate epithelia. Additionally demonstrated herein, through AR gain- and loss-of-function experiments, are the novel growth and differentiation roles of epithelial AR within the normal and cancerous prostate cells.
    Type: Application
    Filed: May 21, 2007
    Publication date: January 21, 2010
    Applicant: University of Rochester
    Inventor: Chawnshang Chang
  • Methods and Compositions Related to TR4
    Publication number: 20090305980
    Abstract: Disclosed are compositions and methods related to TR4 and cancer.
    Type: Application
    Filed: May 9, 2007
    Publication date: December 10, 2009
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Yi-Fen Lee, Chawnshang Chang
  • Androgen Receptor Related Methods for Treating Bladder Cancer
    Publication number: 20090282496
    Abstract: Disclosed are compositions and methods for treating bladder cancer.
    Type: Application
    Filed: April 3, 2009
    Publication date: November 12, 2009
    Applicant: University of Rochester Medical Center
    Inventor: Chawnshang Chang
  • Curcumin analogues and uses thereof
    Patent number: 7595346
    Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: September 29, 2009
    Assignees: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience Corporation
    Inventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
  • Methods and Compositions Related to TR4
    Publication number: 20090012019
    Abstract: Disclosed are compositions and methods related to TR4 and aging.
    Type: Application
    Filed: January 20, 2006
    Publication date: January 8, 2009
    Inventors: Chawnshang Chang, Yifen Lee
  • NOVEL CURCUMIN ANALOGUES AND USES THEREOF
    Publication number: 20080161391
    Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
    Type: Application
    Filed: February 13, 2008
    Publication date: July 3, 2008
    Applicants: The University of North Carolina, The University of Rochester Medical Center, Androscience Corporation
    Inventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
  • NOVEL CURCUMIN ANALOGUES AND USES THEREOF
    Publication number: 20080146660
    Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
    Type: Application
    Filed: February 13, 2008
    Publication date: June 19, 2008
    Applicants: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience Corporation
    Inventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
  • Curcumin analogues and uses thereof
    Patent number: 7355081
    Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: April 8, 2008
    Assignees: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience Corporation
    Inventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
  • Non-Androgen Dependent Roles for Androgen Receptor and Non-Androgen Related Inhibitors of Androgen Receptor
    Publication number: 20080050387
    Abstract: Disclosed are compositions and methods for modulating AR activity, such as non-androgen dependent AR activity. Also disclosed are compositions and methods for diagnosing beast cancer and for inhibiting breast cancer growth. In addition, disclosed are methods for identifying molecules that inhibit AR in non-androgen dependent ways.
    Type: Application
    Filed: December 13, 2004
    Publication date: February 28, 2008
    Inventor: Chawnshang Chang
  • Androgen receptor coregulators
    Publication number: 20060270591
    Abstract: Disclosed are compositions and methods related to androgen receptor coregulators.
    Type: Application
    Filed: June 6, 2003
    Publication date: November 30, 2006
    Inventor: Chawnshang Chang