Abstract: An expandable home can expand horizontally with walls and floors that are foldable to the side of the structure. The movable house structure can be road mobile in a stowed state and can be expanded into a multi-bedroom house with a loft in an expanded state. The two outside walls can be driven out from the main body frame and two floor panels are hingedly connected with the body frame to be folded down for the expanded room. There are two retractable roofs on the top of the main structure that can be pulled out with the outside walls. The loft part can be raised from the main structure, where the floor panel for the loft is preset. Two long side wall panels are hingedly connected and folded into the middle while the two short wall panels are inserted into and raised from the short wall panels of first floor.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: The disclosure aims to provide a chemical synthesis method of a prodelphinidin B9 gallate, in which the prodelphinidin B9 gallate is synthesized by using a proanthocyanidin from Chinese bayberry leaves as a raw material, and using epigallocatechin gallate (EGCG) as a nucleophilic reagent to attack C4 sites of subunits EGCG and epigallocatechin (EGC) of the proanthocyanidin from Chinese bayberry leaves in the presence of hydrochloric acid as a catalyst. Compared with prodelphinidin B9 gallates extracted and separated from materials such as tea leaves, and Chinese bayberry leaves, the prodelphinidin B9 gallate prepared by the method provided in the present disclosure has higher purity and yield, and can be directly used as a nutrient enhancer and a natural antioxidant in the field of food.

Abstract: In various examples, policy planning using behavior models for autonomous and semi-autonomous systems and applications is described herein. Systems and methods are disclosed that determine a policy for navigating a vehicle, such as a semi-autonomous vehicle or an autonomous vehicle (or other machine), where the policy allows for multistage reasoning that leverages future reactive behaviors of one or more other objects. For instance, a first behavior model (e.g., a trajectory tree) may be generated that represents candidate trajectories for the vehicle and one or more second behavior models (e.g., one or more scenario trees) may be generated that respectively represent future behaviors of the other object(s). The first behavior model and the second behavior model(s) may then be processed, such as in a closed-loop simulation based on a realistic data-driven traffic model, to determine the policy for navigating the vehicle.

Abstract: A multi-degree-of-freedom active damping mechanism control method, system and a damping mechanism are provided. A skyhook active damping control algorithm is used for controlling an electric cylinder output force in a vertical damping direction, and an adaptive control algorithm with an adaptive rate is used for correcting a load moment of inertia in pitch and roll damping directions. At the same time, a predictive model is established according to a task space linearization equation near an equilibrium point, and states of the system at N future moments are predicted in advance at each moment to achieve optimal control under complex constraints and reduce the influence of system delay. At the same time, the three control methods may further improve the active damping effect of the damping device by combining road information obtained by a visual sensor in real time.

Abstract: A method for making intermediate compounds suitable for making muscenone, the compositions made by said methods, the various uses of said compositions, and enzyme variants useful in said methods.

Abstract: A method for quickly acquiring soil hydraulic properties in situ based on a ponded infiltration experiment is provided. The method adopts a novel derivation method, and is based on a Richards' equation and a Brooks-Corey model to derive an analytical solution that accurately describes one-dimensional infiltration into homogeneous soil under ponded conditions. The method, for the first time, provides a detailed description of a developing saturated zone in the soil water profile, which is the most vital infiltration characteristic during ponded infiltration. The method proposes an optimized estimation method for parameters based on an inverse process of the analytical solution. The method can quickly acquire soil hydraulic properties in situ field by measuring a cumulative infiltration amount and a length of a wetting front over time during one-dimensional ponded infiltration experiment through a time-domain reflectometer (TDR).

Abstract: In example implementations, an apparatus is provided. The apparatus includes an interface, an integrated graphical processing unit (GPU), a discrete GPU, and a controller. The interface is to receive a connection to an external display device. The integrated GPU and the discrete GPU are communicatively coupled to the interface. The controller is communicatively coupled to the integrated GPU and the discrete GPU and is to deactivate the discrete GPU and activate the integrated GPU in response to detection of the external display device connected to the interface.

Abstract: In an embodiment, a chemical mechanical planarization (CMP) system includes: a monolithic platen within a platen housing, wherein the monolithic platen is formed of a single piece of material, wherein the monolithic platen includes: a first portion within a first opening, and a second portion within a second opening, wherein the first portion has a different diameter than the second portion; and a polishing fluid delivery module above the monolithic platen, wherein the polishing fluid delivery module is configured to deliver slurry to the monolithic platen during performance of CMP.

Abstract: A liquid product container has a container body, a valve, a liquid dip tube, and an extending drawing unit. The valve is sealed on the installing opening of the container body. The liquid dip tube is mounted on the valve. The extending drawing unit has a main body. The main body is mounted in the container body and extend to a bottom edge of the container body. The main body has multiple extending liquid drawing passages extending along a radial direction of the container body and respectively form multiple extending liquid drawing openings. The extending liquid drawing openings are located in the bottom edge of the container body. The main body has a connecting port segment connected to the extending liquid drawing passages and connected to the liquid dip tube, such that the liquid dip tube is connected to the extending liquid drawing openings.

Abstract: A driving head-changeable tool is provided, including: a main body, including a chamber and an assembling end, the chamber including concave portions and convex portions alternatively arranged circumferentially, the chamber further including at least one receiving hole each receiving a blocking member; an outer sleeve, disposed around the main body, including a recess and a projection protrusive, the outer sleeve being slidable relative to the main body; wherein when the outer sleeve is located in a first position, the projection urges the blocking member to project within the chamber to retain the polygonal ball joint in the chamber; when the outer sleeve is located in a second position, the blocking member is retractable in the recess to be not protrusive within the chamber so that the polygonal ball joint is disengageable from the chamber.

Abstract: Provided are binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof, comprising a CH1 domain (e.g., a human IgG1 CH1 domain), wherein the CH1 domain has an engineered N-linked glycosylation site at amino acid position 114, according to Kabat numbering. Also provided are nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: Provided is a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: A rigid non-isocyanate polyurethane foam and a preparation method therefor are provided. According to the present application, a rigid epoxide is firstly reacted with carbon dioxide to obtain rigid cyclic carbonate, then the product is reacted with diamine to obtain rigid non-isocyanate polyurethane, and the rigid non-isocyanate polyurethane is mixed with a foaming agent for foaming to obtain rigid non-isocyanate polyurethane foam. The present application improves the mechanical property of non-isocyanate polyurethane by optimizing the structures and groups of raw materials; according to the present application, mild reaction conditions such as atmospheric pressure and low temperature are used, and the amounts of reactants and foaming agents are adjusted, so that the reaction is significantly enhanced, and an excellent foaming effect is achieved.

Abstract: Provided herein are inhibitors of receptor tyrosine kinase effector, RAF, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Abstract: Provided are suspension-based cell culture systems and media for the timely and efficient proliferation of human tumor cell clusters from a patient, and related methods of evaluating the potential responsiveness of the tumor cells and the patient to one or more therapeutic agents.

Abstract: The present invention relates to novel antimicrobial peptides and compositions comprising the same. The present invention also provides a method for for treating microbial infections, including bacterial infections and fungal infections.

Abstract: A reconsolidated bamboo beam-column joint connected by a subassembly and a design method thereof are provided. Rectangular shear steel plates and vertical steel plates in embedded steel plates form an H-shaped section, and left and right ends of the vertical steel plates are embedded in mortises of a reconsolidated bamboo column and a reconsolidated bamboo beam respectively, thereby effectively improving bearing capacity of the joint. A half tenon is provided with an elliptical bolt hole in a penetrating manner and connected to the reconsolidated bamboo column by a bolt, and the half tenon is rotatable along a center of the elliptical bolt hole and movable along a long axis of the elliptical bolt hole, so that the energy is dissipated through friction between the reconsolidated bamboo half tenon and mortises, excellent energy consumption ability of the half tenon structure is exerted, and the anti-pulling resistance of the tenon is improved.

Abstract: Described herein are peptides and peptide-antibody fusions that bind to the SARS-CoV-2 S protein and the receptor binding domain (RED), and methods for using the compositions containing these antibodies in the treatment of COVID-19, Specifically, we developed novel CoV-2 S protein binding peptides making use of a naïve phage-displayed 16mer peptide library—wherein the CoV-2 S protein binding peptides bind epitopes in both the RBD and S protein outside of the RBD. In addition, we show that fusion of these peptides to the N-terminus of nAbs improves their apparent affinity, potency and breadth of neutralization, without compromising their developability profile, Thus, these peptides represent a novel class of SARS-CoV-2 S protein binders, which can be formatted in various ways to improve functional properties of nAbs to be used in the treatment of many different diseases.

Abstract: The present disclosure relates to the fields of a method a kit for molecular diagnostics and genomics. More particularly, this disclosure relates to a method and a kit fir detecting a DNA fragment joining event or distinguishing an alternative splicing event. The present disclosure also relates to a method for administering a subject with proper treatment by steps of determining the risk of a particular cancer type or genotype.