Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.

Abstract: A method for removing a heavy metal from water includes subjecting a microbial solution containing a liquid culture of a urease-producing bacterial strain and a reaction solution containing a manganese compound and urea to a microbial-induced precipitation reaction, so as to obtain biomineralized manganese carbonate (MnCO3) particles, admixing the biomineralized MnCO3 particles with water containing a heavy metal, so that the biomineralized MnCO3 particles adsorb the heavy metal in the water to form a precipitate, and removing the precipitate from the water.

Abstract: A semiconductor package including a first semiconductor die, a second semiconductor die, a first insulating encapsulation, a dielectric layer structure, a conductor structure and a second insulating encapsulation is provided. The first semiconductor die includes a first semiconductor substrate and a through silicon via (TSV) extending from a first side to a second side of the semiconductor substrate. The second semiconductor die is disposed on the first side of the semiconductor substrate. The first insulating encapsulation on the second semiconductor die encapsulates the first semiconductor die. A terminal of the TSV is coplanar with a surface of the first insulating encapsulation. The dielectric layer structure covers the first semiconductor die and the first insulating encapsulation. The conductor structure extends through the dielectric layer structure and contacts with the through silicon via.

Abstract: In some embodiments, an image sensor is provided. The image sensor includes a photodetector disposed in a semiconductor substrate. A wave guide filter having a substantially planar upper surface is disposed over the photodetector. The wave guide filter includes a light filter disposed in a light filter grid structure. The light filter includes a first material that is translucent and has a first refractive index. The light filter grid structure includes a second material that is translucent and has a second refractive index less than the first refractive index.

Abstract: An electronic device includes a processor circuit, a frequency-domain-to-time-domain conversion circuit, a transmitter circuit, a hybrid circuit, a receiver circuit, and a time-domain-to-frequency-domain conversion circuit. The processor circuit generates a frequency-domain transmitting signal. The frequency-domain-to-time-domain conversion circuit converts the frequency-domain transmitting signal into a first time-domain transmitting signal. The transmitter circuit generates a second time-domain transmitting signal. The hybrid circuit includes an echo noise cancelling path and an echo noise path. When the echo noise cancelling path is turned off, the processor circuit receives a first frequency-domain receiving signal. When the echo noise cancelling path is turned on, the processor circuit receives a second frequency-domain receiving signal.

Abstract: The present disclosure, in some embodiments, relates to a method of forming an integrated chip structure. The method may be performed by forming a plurality of interconnect layers within a first interconnect structure disposed over an upper surface of a first semiconductor substrate. An edge trimming process is performed to remove parts of the first interconnect structure and the first semiconductor substrate along a perimeter of the first semiconductor substrate. The edge trimming process results in the first semiconductor substrate having a recessed surface coupled to the upper surface by way of an interior sidewall disposed directly over the first semiconductor substrate. A dielectric capping structure is formed onto a sidewall of the first interconnect structure after performing the edge trimming process.

Abstract: A system for compensating acceleration of electrical motorbike includes a throttle unit and an electro-mechanic assembly. After the electrical motorbike starts, the throttle unit receives external operation from a rider for generating a series of original throttle signal. An acceleration compensating module calculates a throttle variation rate based on the original throttle signal and variation of a throttle operation magnitude, and calculates a throttle compensating value based on the throttle variation rate when the throttle variation rate is larger than or equal to a correction threshold. A throttle compensating module receives and sums the original throttle signal and the throttle compensating value up for generating a new throttle signal. A torque controller generates a corresponding torque command based on the new throttle signal, and outputs the torque command to the electro-mechanic assembly for operation.

Abstract: An arm muscular strength training and rehabilitation apparatus has a body, an angle meter, a handle, a force sensing device and a main control unit. The body has a housing and a variable resistance device. The variable resistance device is disposed in the housing. The angle meter is disposed on the variable resistance device. The handle is disposed pivotally on the variable resistance device and has a suspension arm and a handlebar bracket. The force sensing device is disposed on handlebar bracket of the handle. The main control unit connects electrically to the variable resistance device, the angle meter and the force sensing device to receive the angle signal and the force sensing signal and controls resistance of the variable resistance device according to the angle signal and the force sensing signal. The apparatus disposing the force sensing device on the handle prevents measuring time lag and increase measuring precision.

Abstract: A system for compensating acceleration of electrical motorbike includes a throttle unit and an electro-mechanic assembly. After the electrical motorbike starts, the throttle unit receives external operation from a rider for generating a series of original throttle signal. An acceleration compensating module calculates a throttle variation rate based on the original throttle signal and variation of a throttle operation magnitude, and calculates a throttle compensating value based on the throttle variation rate when the throttle variation rate is larger than or equal to a correction threshold. A throttle compensating module receives and sums the original throttle signal and the throttle compensating value up for generating a new throttle signal. A torque controller generates a corresponding torque command based on the new throttle signal, and outputs the torque command to the electro-mechanic assembly for operation.

Abstract: An arm muscular strength training and rehabilitation apparatus has a body, an angle meter, a handle, a force sensing device and a main control unit. The body has a housing and a variable resistance device. The variable resistance device is disposed in the housing. The angle meter is disposed on the variable resistance device. The handle is disposed pivotally on the variable resistance device and has a suspension arm and a handlebar bracket. The force sensing device is disposed on handlebar bracket of the handle. The main control unit connects electrically to the variable resistance device, the angle meter and the force sensing device to receive the angle signal and the force sensing signal and controls resistance of the variable resistance device according to the angle signal and the force sensing signal. The apparatus disposing the force sensing device on the handle prevents measuring time lag and increase measuring precision.

Abstract: A handheld electronic apparatus and an incoming call processing method of the handheld electronic apparatus are provided. When an incoming call is received, a type of an operating interface displayed on a touch display screen is determined; according to the type of the operating interface, it is decided whether to display a sub-call window interface on the operating interface.

Abstract: A handheld electronic apparatus and an incoming call processing method of the handheld electronic apparatus are provided. When an incoming call is received, a type of an operating interface displayed on a touch display screen is determined; according to the type of the operating interface, it is decided whether to display a sub-call window interface on the operating interface.

Abstract: A bit sharpener includes a casing with a front plate having a first tube extending therefrom and a rear plate with a plurality of first holes defined therein, the rear plate having a first tubular member and a first rod centrally extending from an inner side thereof such that a guide plate is mounted to the first tubular member and a grinding member is mounted to the guide plate, a rotating member connected to the grinding member and receiving the first rod therein with two springs disposed between the grinding member, the first rod and an inner side of a front end of the rotating member, the front end of the rotating member having a cone-shaped recess defined in a front side thereof for jaws of a hand drill inserted therein to rotate the rotating member and the grinding member such that when a bit is inserted through the first hole and the vent, the bit is ground by the grinding member.